本文關鍵詞： 金屬接骨板 可降解鎂合金 微弧氧化 力學性能 微動磨損　出處：《西南交通大學》2017年碩士論文　論文類型：學位論文

【摘要】：隨著骨折內(nèi)固定技術的發(fā)展,接骨板在臨床上得到廣泛應用。一方面,現(xiàn)階段用于骨折堅強內(nèi)固定的接骨板材料多為不銹鋼、鈦及鈦合金等具有高彈性模量的生物惰性金屬。然而,這些傳統(tǒng)接骨板的結構剛度較高,不僅會導致應力遮擋,而且阻礙骨折塊間形成適當?shù)妮S向位移,不利于骨折愈合。此外,生物惰性金屬接骨板在骨折愈合后需要手術取出,給患者帶來額外痛苦。鑒于鎂合金不僅具有良好的機械性能,而且可在生物體內(nèi)無毒降解,因此,生物可降解鎂合金在骨折內(nèi)固定器械方面具有廣闊的應用前景�，F(xiàn)有研究主要關注鎂合金在生物體內(nèi)的降解行為、對骨折修復的影響及其生物相容性等。實際上,鎂合金接骨板—骨折系統(tǒng)良好的機械性能是保證骨折有效愈合的重要因素,但這方面的研究目前尚未見系統(tǒng)報道。因此,很有必要開展鎂合金接骨板機械性能的研究,研究結果有助于促進鎂合金在骨折內(nèi)固定中的臨床應用。本論文利用力學測試平臺,對比研究了擠壓態(tài)ZK60鎂合金和TA3純鈦接骨板固定股骨干不穩(wěn)定骨折時的力學性能;并采用微弧氧化處理在ZK60鎂合金表面制備了不同的微弧氧化陶瓷層,采用體外微動模擬試驗,考察了 ZK60鎂合金試樣在接骨板服役工況下的微動磨損行為,揭示了電壓、占空比等微弧氧化電參數(shù)對ZK60鎂合金表面微動磨損性能的影響規(guī)律。主要結果與結論如下:(1)ZK60鎂合金接骨板固定股骨干不穩(wěn)定型骨折時具有較低的靜態(tài)結構剛度,更趨于彈性固定從而有助于減小應力遮擋作用,它不僅能在骨折初期有效承載,還能確保骨折塊間具有足夠的軸向位移以刺激骨痂形成,其骨折愈合性能優(yōu)于TA3純鈦接骨板。然而,ZK60接骨板—骨折結構的靜態(tài)強度和軸向載荷下的疲勞強度均低于TA3接骨板。(2)ZK60表面的微弧氧化層能顯著提高其在接骨板服役工況下的耐腐蝕性能,試樣表面的腐蝕電流密度及腐蝕速率均明顯降低。(3)微弧氧化處理能顯著提高ZK60鎂合金表面在接骨板服役工況下的耐微動磨損性能,微弧氧化電壓對其具有顯著影響,不同脈沖占空比則無顯著影響。隨電壓升高,微弧氧化ZK60在模擬體液中的耐微動磨損性能先增后減,最佳電壓為350 V。
[Abstract]:With the development of fracture internal fixation technology, bone plate has been widely used in clinic. On the one hand, most of the materials used for internal fixation of fracture are stainless steel. Titanium and titanium alloys are biologically inert metals with high modulus of elasticity. However, the structural stiffness of these traditional plates is relatively high, which not only leads to stress occlusion, but also hinders the formation of proper axial displacement between fracture fragments. In addition, biological inert metal plates need to be surgically removed after fracture healing, causing additional pain to patients. Since magnesium alloys not only have good mechanical properties, but also can be detoxified in organisms, so, Biodegradable magnesium alloys have a broad application prospect in fracture internal fixation devices. The current research focuses on the biodegradation behavior of magnesium alloys in vivo, the effects on fracture repair and their biocompatibility. The good mechanical properties of the magnesium alloy plate fracture system is an important factor to ensure the effective healing of the fracture, but the research on this aspect has not been systematically reported. Therefore, it is necessary to study the mechanical properties of the magnesium alloy bone plate. The results are helpful to promote the clinical application of magnesium alloy in fracture internal fixation. In this paper, the mechanical properties of extruded ZK60 magnesium alloy and TA3 pure titanium plate were compared with each other in the treatment of unstable femoral shaft fracture. Different micro-arc oxidation ceramic coatings were prepared on the surface of ZK60 magnesium alloy by micro-arc oxidation. The fretting wear behavior of ZK60 magnesium alloy under service condition was investigated by in vitro fretting simulation test, and the voltage was revealed. The effect of duty cycle on the fretting wear properties of ZK60 magnesium alloy surface is studied. The main results and conclusions are as follows: 1 / 1 mg alloy plate fixation of unstable femoral shaft fracture has low static structural stiffness. More elastic fixation helps reduce stress occlusion, not only in the early stages of the fracture, but also in ensuring that there is enough axial displacement between the pieces to stimulate callus formation. The fracture healing performance of ZK60 is better than that of pure titanium TA3 plate. However, the static strength and fatigue strength of ZK60 plate under axial load are lower than that of TA3 plate. Corrosion resistance under service conditions, The corrosion current density and corrosion rate on the surface of the ZK60 magnesium alloy decreased significantly. The micro-arc oxidation treatment could significantly improve the fretting wear resistance of the surface of ZK60 magnesium alloy under the service condition of the bone-plate, and the micro-arc oxidation voltage had a significant effect on the micro-arc oxidation. With the increase of voltage, the fretting wear resistance of ZK60 in simulated body fluid increased first and then decreased, and the optimum voltage was 350V.
【學位授予單位】：西南交通大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：TG146.22;R318.08

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