本文選題：微流體 + 微尺度��； 參考：《浙江大學(xué)》2016年博士論文

【摘要】：由于微流體設(shè)備在高效傳熱傳質(zhì)、精細(xì)高附加值化學(xué)品生產(chǎn)等領(lǐng)域廣闊的應(yīng)用前景,有關(guān)微尺度下液體流動(dòng)、傳熱特性的研究也越來越受到人們的重視。常規(guī)尺度下液體的流動(dòng)、傳熱特性理論在微尺度下是否適用,在常規(guī)尺度下可以忽略的因素在微尺度下是否會(huì)對(duì)流動(dòng)、傳熱產(chǎn)生明顯的影響等問題都需要深入分析和探討。本文研究了不同流體(包括去離子水、離子液體1-乙基-3-甲基咪唑硫酸乙酯水溶液和硝酸鈉水溶液)在微尺度下的流動(dòng)特性,使用COMSOL Multiphysics軟件模擬了離子液體水溶液在微尺度下的流動(dòng)、傳熱特性,并考察了微流體設(shè)備中制備mPEG-PLGA納米顆粒的過程特性。主要內(nèi)容如下：1.研究了去離子水在管徑范圍為44.5-1011 μm,粗糙度(相對(duì)粗糙度)范圍為0.1-5.2 μm(0.02-4.32%)的三種不同材料(不銹鋼SS、聚醚醚酮塑料PEEK和石英FS)管道內(nèi)的流動(dòng)特性,得到了雷諾數(shù)范圍為29-11644的2502個(gè)摩擦系數(shù)與雷諾數(shù)關(guān)系的數(shù)據(jù)點(diǎn)。本文提出了特征參數(shù)α來描述微尺度(1-1000μm)與常規(guī)尺度(≥1000μm)的偏離程度,基于該特征參數(shù)提出了計(jì)算微尺度下臨界雷諾數(shù)的關(guān)聯(lián)式(與實(shí)驗(yàn)值的平均絕對(duì)偏差A(yù)AD為1.9%)以及計(jì)算微尺度下湍流區(qū)摩擦系數(shù)的修正的Moody方程(與實(shí)驗(yàn)值的平均絕對(duì)偏差A(yù)AD為2.4%)。2.研究了濃度分別為10-2、10-4和10-6 mol·L-1離子液體1-乙基-3-甲基咪唑硫酸乙酯([C2mim][EtSO4])水溶液和硝酸鈉水溶液在管徑范圍為44.5-102.5 μmPEEK材料微管(光滑管道)內(nèi)的流動(dòng)特性。發(fā)現(xiàn)電黏性效應(yīng)在微管管徑大于等于44.5μm時(shí)可以忽略,而且離子液體水溶液與普通電解質(zhì)水溶液的流動(dòng)特性相同。同時(shí)使用COMSOL Multiphysics軟件模擬了管徑(1-100 μm)和流體濃度(10-2、10-4、10-6 mol·L1)這兩個(gè)變量對(duì)離子液體水溶液流動(dòng)過程中電黏性效應(yīng)大小的影響。發(fā)現(xiàn)當(dāng)流體濃度減小到106 mol·L1,微管管徑小于等于10μm時(shí),電黏性效應(yīng)對(duì)流動(dòng)特性的影響大于5%,此時(shí)電黏性效應(yīng)的影響不可忽略。3.測(cè)定了離子液體[C2mim][EtSO4]及其相關(guān)體系的導(dǎo)熱系數(shù),基于二階Scheffe多項(xiàng)式擬合得到了不同溫度、濃度條件下導(dǎo)熱系數(shù)的關(guān)聯(lián)式�；谕�?fù)渲笖?shù)法,提出了一個(gè)模型來估算離子液體導(dǎo)熱系數(shù)。然后使用COMSOL Multiphysics軟件模擬了管徑(1-100μm)和流體濃度(10-2,10-4,10-6 mol·L-1)這兩個(gè)變量對(duì)離子液體水溶液傳熱過程中電黏性效應(yīng)大小的影響。發(fā)現(xiàn)當(dāng)流體濃度減小到10-6mol·L-1,微管管徑小于等于5μm時(shí),電黏性效應(yīng)對(duì)傳熱特性的影響大于5%,此時(shí)電黏性效應(yīng)的影響不可忽略。4.使用光刻方法制作了PDMS材料微流體設(shè)備,在該設(shè)備內(nèi)穩(wěn)定層流流動(dòng)狀態(tài)下,通過控制流量比率、mPEG-PLGA相對(duì)分子量和濃度等工藝條件,制備得到了粒徑范圍為19-129nm的mPEG-PLGA納米顆粒。發(fā)現(xiàn)微流體法可以實(shí)現(xiàn)粒徑的較好控制,且得到的納米顆粒的PDI等性能均優(yōu)于傳統(tǒng)方法制備得到的納米顆粒。同時(shí)在微流體設(shè)備中采用布洛芬和姜黃素這兩種藥物制備了包裹藥物的mPEG-PLGA納米顆粒,得到了較好的藥物包裹率、載藥量和體外緩釋曲線。
[Abstract]:Due to the wide application of microfluidic equipment in the field of high efficiency heat and mass transfer, fine and high value-added chemical production, the research of liquid flow and heat transfer characteristics in micro scale has been paid more and more attention. This paper studies the flow characteristics of different fluids (including deionized water, ionic liquid 1- ethyl -3- methyl imidazole sulfate aqueous solution and sodium nitrate water solution) at microscale, using COMSOL Multiphysics soft. The flow and heat transfer characteristics of the ionic liquid aqueous solution at microscale are simulated and the process characteristics of the preparation of mPEG-PLGA nanoparticles in the microfluidic equipment are investigated. The main contents are as follows: 1. the three different materials of the deionized water in the diameter range of 44.5-1011 mu m and the roughness (relative roughness) range of 0.1-5.2 mu m (0.02-4.32%) are studied. The flow characteristics in the pipes (stainless steel SS, peek plastic PEEK and quartz FS) have been obtained. The data points of the relation between the Reynolds number and the Reynolds number of 2502 of the Reynolds number range are 29-11644. The characteristic parameter alpha is proposed to describe the deviation degree between the micro scale (1-1000 Mu m) and the conventional scale (> 1000 mu m), and the calculation is based on the characteristic parameters. The correlation formula of the critical Reynolds number in microscale (the mean absolute deviation AAD of the experimental value is 1.9%) and the modified Moody equation for calculating the friction coefficient of the turbulent zone in the micro scale (the mean absolute deviation AAD of the experimental value is 2.4%).2., the concentration is 10-2,10-4 and 10-6 mol L-1 ionic liquid 1- ethyl -3- methyl imidazole sulfate ([C), respectively ([C, [C). 2mim][EtSO4]) the flow characteristics of the aqueous solution and the sodium nitrate solution in the tube diameter range of 44.5-102.5 micron microtubule (smooth pipe). It is found that the electric viscosity effect can be ignored when the tube diameter is greater than 44.5 u m, and the flow characteristics of the ionic liquid water solution and the ordinary electrolyte water solution are the same. At the same time, the COMSOL Multiphys is used in the COMSOL Multiphys. The ICs software simulates the effect of the two variables of the pipe diameter (1-100 mu m) and the fluid concentration (10-2,10-4,10-6 mol. L1) on the electric viscosity effect on the flow of ionic liquid water solution. It is found that when the fluid concentration is reduced to 106 mol L1 and the tube diameter is less than 10 mu m, the effect of the electrical viscosity on the flow characteristics is greater than 5%, and the electrical viscosity at this time is more than 5%. The effect of the effect can not be ignored by.3. to determine the thermal conductivity of the ionic liquid [C2mim][EtSO4] and its related systems. Based on the two order Scheffe polynomial fitting, the correlation of thermal conductivity under different temperatures and concentrations is obtained. Based on the topological index method, a model is proposed to estimate the thermal conductivity of ionic liquids. Then COMSOL Multiphy is used. The sics software simulates the effect of the two variables of the pipe diameter (1-100 mu m) and the fluid concentration (10-2,10-4,10-6 mol. L-1) on the electric viscosity effect during the heat transfer of ionic liquid aqueous solution. It is found that when the fluid concentration is reduced to 10-6mol L-1 and the tube diameter is less than 5 mu m, the effect of the electrical viscosity on the heat transfer characteristics is greater than 5%, and the electrical viscosity is at this time. The effect can not be ignored by.4. using photolithography to make PDMS microfluidics. Under the stable laminar flow state, the mPEG-PLGA nanoparticles with a particle size range of 19-129nm are prepared by controlling the flow rate, mPEG-PLGA relative molecular weight and concentration. It is found that the particle size can be achieved by the microfluidic method. The properties of PDI nanoparticles are better than those obtained by traditional methods. At the same time, mPEG-PLGA nanoparticles are prepared by two kinds of drugs, ibuprofen and curcumin, in the microfluidic equipment. The better drug encapsulation rate, drug loading and in vitro release curve are obtained.

【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2016
【分類號(hào)】：TQ021.3
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本文編號(hào)：1790911