報(bào)道了一種可見光誘導(dǎo)Barton脫羧的新方法.在不需要外加自由基引發(fā)劑的條件下,可以實(shí)現(xiàn)一系列一級(jí)、二級(jí)、三級(jí)以及氨基酸、多肽類氧化還原性羧酸酯脫羧,而且許多含有羧基的天然產(chǎn)物及藥物分子也可以很好地發(fā)生轉(zhuǎn)化,反應(yīng)條件溫和、底物范圍廣,具有良好的收率和官能團(tuán)兼容性.初步機(jī)理實(shí)驗(yàn)研究表明,三（三甲基硅基）硅烷在該反應(yīng)體系中不僅作為氫源,同時(shí)也作為電子給體和氧化還原性羧酸作用形成電子供體-受體復(fù)合物,反應(yīng)經(jīng)歷自由基歷程. 

【文章來源】：中國科學(xué)技術(shù)大學(xué)學(xué)報(bào). 2020,50(11)北大核心CSCD

【文章頁數(shù)】：8 頁

【文章目錄】：
1 Introduction
2 Results and discussion
    2.1 Screening of reaction conditions
    2.2 Scope of the decarboxylation
    2.3 Mechanistic investigation
3 Conclusions
4 Experimental section
    4.1 General procedure
    4.2 Characterization data for products
Conflict of interest


【參考文獻(xiàn)】：
期刊論文
[1]Transition metal-catalyzed decarboxylative cross-coupling reactions[J]. SHANG Rui~1 & LIU Lei~1,2*1Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education); Department of Chemistry, Tsinghua University, Beijing 100084, China 2State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032,China.  Science China（Chemistry）. 2011(11)



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