【摘要】：對(duì)叔丁醇鉀參與下芳甲基疊氮發(fā)生脫氮、水解反應(yīng)進(jìn)行了深入研究,得到芳甲醛.實(shí)驗(yàn)中,探討了堿、水解條件、溶劑及堿量對(duì)苯甲醛反應(yīng)產(chǎn)率的影響.研究發(fā)現(xiàn),以N,N-二甲基甲酰胺(DMF)為溶劑,以叔丁醇鉀(t-BuOK)為堿,反應(yīng)效果最佳,以83%的產(chǎn)率得到苯甲醛.同時(shí),對(duì)不同結(jié)構(gòu)的疊氮化合物進(jìn)行了考察,取代苯甲基疊氮能夠順利反應(yīng),得到相應(yīng)的芳醛和芳酮,產(chǎn)率38%~87%,其他芳甲基疊氮化合物反應(yīng)效果差.根據(jù)控制實(shí)驗(yàn),探討了反應(yīng)機(jī)理.
[Abstract]:The denitrification and hydrolysis of arylmethyl azide with the participation of potassium tert-butylalcohol were studied to obtain aromatic formaldehyde. The effects of alkali, hydrolysis conditions, solvent and alkali content on the yield of benzaldehyde were discussed. It was found that benzaldehyde was obtained with N, N-dimethyl formamide (DMF) as solvent and potassium tert-butylalcohol (t-BuOK) as base. Benzaldehyde was obtained in 83% yield. At the same time, azide compounds with different structures were investigated. Substituted phenylmethyl azide could react smoothly, and the corresponding aromatic alaldehyde and aromatic ketone were obtained, the yield was 38% 鈮，

本文編號(hào)：2504082