【摘要】：介紹了氧化石墨烯作為一種高效且可回收的催化劑應(yīng)用于2,5-己二酮與苯胺通過Paal-Knorr縮合反應(yīng)合成N-取代吡咯。研究了反應(yīng)時間、反應(yīng)溫度、溶劑、催化劑用量以及苯胺與2,5-己二酮的摩爾比對2,5-二甲基-N-苯基吡咯收率的影響。通過原位核磁技術(shù)在分子水平上跟蹤了Paal-Knorr縮合的反應(yīng)過程。結(jié)果表明在25℃下通過氧化石墨烯的催化作用反應(yīng)6 h后吡咯的最大收率可達(dá)到90%。氧化石墨烯易回收,且經(jīng)5次回收使用后還能表現(xiàn)出很好的循環(huán)使用性和高催化性能。
[Abstract]:N-substituted pyrrole was synthesized by Paal-Knorr condensation of 2,5-hexanedione with aniline using graphene oxide as an efficient and recyclable catalyst. The effects of reaction time, reaction temperature, solvent, catalyst amount and molar ratio of aniline to 2,5-hexanedione on the yield of 2,5-dimethyl-N-phenyl pyrrole were studied. In situ NMR technique was used to track the reaction process of Paal-Knorr condensation at the molecular level. The results show that the maximum yield of pyrrole can reach 90% after 6 h of catalytic reaction of graphene oxide at 25 鈩，

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