【摘要】：甲基是最小的含碳取代基團(tuán),在化合物中起到重要的作用.羧酸轉(zhuǎn)化為酮是有機(jī)化學(xué)的基礎(chǔ)反應(yīng),這種官能團(tuán)變化通常是間接地將羧酸先轉(zhuǎn)化為酰氯或者Weinreb酰胺再由有機(jī)金屬試劑進(jìn)行親核進(jìn)攻.直接將羧酸轉(zhuǎn)變?yōu)橥?需要至少2 equiv.鋰試劑,同時反應(yīng)需要在低溫下進(jìn)行,往往伴隨著很多叔醇的副產(chǎn)物.報道了利用鎳催化還原偶聯(lián)的方法,將有機(jī)羧酸與對甲苯磺酸甲酯進(jìn)行還原偶聯(lián),一步反應(yīng)直接由羧酸甲基化成酮,其特點是原料易得,反應(yīng)條件溫和,可以得到中等的收率并且有較好的底物適應(yīng)性.
[Abstract]:Methyl is the smallest carbon substituted group and plays an important role in compounds. The conversion of carboxylic acid to ketone is the basic reaction of organic chemistry. This functional group change is usually the conversion of carboxylic acid to acyl chloride or Weinreb amide and then nucleophilic attack by organometallic reagent. Direct conversion of carboxylic acid to ketone requires at least 2 equiv. Lithium reagents, which simultaneously react at low temperatures, are often accompanied by by-products of tertiary alcohols. The reduction coupling of organic carboxylic acid with methyl p-toluenesulfonate by nickel catalytic reduction coupling was reported. The one-step reaction was directly from carboxylic acid methylation to ketone. The characteristics of the reaction were that the raw material was easy to be obtained and the reaction conditions were mild. Medium yield and good substrate adaptability can be obtained.
【作者單位】： 上海大學(xué)材料科學(xué)與工程學(xué)院;上海大學(xué)理學(xué)院化學(xué)系;
【基金】：國家自然科學(xué)基金(No.61204020) 上海市教委創(chuàng)新(No.15ZZ047)資助項目~~
【分類號】：O621.251
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本文編號：2417795