新型吲唑類、四嗪類與吡啶并吡唑類農(nóng)藥的合成及其生物活性研究
發(fā)布時(shí)間：2018-11-21 10:10
【摘要】：本文通過模仿、改造、替換基團(tuán),設(shè)計(jì)并合成了一系列新型吲唑類、四嗪類以及吡啶并吡唑酰胺類農(nóng)藥,并通過氣質(zhì)聯(lián)用、核磁氫譜等檢測(cè)手段對(duì)其化學(xué)結(jié)構(gòu)進(jìn)行驗(yàn)證表征,樣品經(jīng)過生物活性測(cè)試,篩選出了多個(gè)優(yōu)于現(xiàn)有商業(yè)品種的農(nóng)藥新品種。吲唑類植物生長(zhǎng)調(diào)節(jié)劑,具有促進(jìn)根系生長(zhǎng)以及對(duì)水分的吸收,還可以加速果實(shí)的脫落和成熟。本文主要對(duì)吲唑乙氧酸(酯)的結(jié)構(gòu)進(jìn)行模仿改造,并合成了一系列6個(gè)吲唑類化合物,生物活性測(cè)試表明,其中化合物Ⅰ、化合物Ⅱ具有較高活性,它們對(duì)小麥的發(fā)芽和根系生長(zhǎng)有良好的促進(jìn)作用,促進(jìn)率都超過了相對(duì)應(yīng)的參照化合物。氟螨嗪是目前效果較好、殺螨廣譜的農(nóng)藥品種,對(duì)多種害螨都具有較好的防治效果;氟螨嗪不僅對(duì)螨卵有特效,同時(shí)對(duì)幼螨也有不錯(cuò)的效果,而且氟螨嗪還對(duì)雌成螨有絕育的作用。本文根據(jù)氟螨嗪的結(jié)構(gòu)特點(diǎn),改變四嗪環(huán)兩側(cè)的活性基團(tuán),合成了一系列6個(gè)四嗪類化合物,其中化合物Ⅲ、化合物Ⅳ的殺螨效果遠(yuǎn)遠(yuǎn)超過對(duì)照藥氟螨嗪。含吡啶連吡唑的酰胺類殺蟲劑氯蟲苯甲酰胺,是一種殺蟲速度快、殺蟲效果好、殺蟲廣譜的殺蟲劑,常被用于蔬菜、水果、水稻、棉花等農(nóng)作物害蟲的防治。氯蟲苯甲酰胺的殺蟲效果不只作用于成蟲,而且對(duì)于幼蟲也有良好的生物活性,且殺蟲效果迅速、具有長(zhǎng)持效。本文設(shè)計(jì)合成制備了13種未見報(bào)道的吡啶并吡唑和吡啶并異VA唑芳香酰胺類化合物,并對(duì)其進(jìn)行了殺蟲生物活性測(cè)試,其中大部分都具有活性,部分化合物活性較高,但均未超過氯蟲苯甲酰胺。
[Abstract]:In this paper, a series of new indazole, tetrazines and pyridinopyrazolamide pesticides were designed and synthesized by imitating, modifying and replacing groups, and their chemical structures were characterized by GC-MS and NMR. After bioactivity test, several new pesticide varieties were selected which were superior to the existing commercial varieties. Indazole plant growth regulators can promote root growth and water absorption, but also accelerate fruit shedding and maturation. In this paper, the structure of indazolyl ethoxy acid (ester) was modified, and a series of 6 indazole compounds were synthesized. The bioactivity test showed that compounds I and II had high activity. They had a good promoting effect on wheat germination and root growth, and the promotion rate was higher than the corresponding reference compound. Tetromethazine is one of the most effective and widely acaricidal pesticide varieties, which has good control effect on a variety of harmful mites. Tetromethazine not only has a special effect on the eggs of mites, but also has a good effect on young mites, and also has sterilizing effect on female adult mites. A series of six tetrazines were synthesized according to the structural characteristics of Tetromethazine and the active groups on both sides of the tetrazine ring. The mite killing effect of compounds 鈪，
本文編號(hào)：2346664
[Abstract]:In this paper, a series of new indazole, tetrazines and pyridinopyrazolamide pesticides were designed and synthesized by imitating, modifying and replacing groups, and their chemical structures were characterized by GC-MS and NMR. After bioactivity test, several new pesticide varieties were selected which were superior to the existing commercial varieties. Indazole plant growth regulators can promote root growth and water absorption, but also accelerate fruit shedding and maturation. In this paper, the structure of indazolyl ethoxy acid (ester) was modified, and a series of 6 indazole compounds were synthesized. The bioactivity test showed that compounds I and II had high activity. They had a good promoting effect on wheat germination and root growth, and the promotion rate was higher than the corresponding reference compound. Tetromethazine is one of the most effective and widely acaricidal pesticide varieties, which has good control effect on a variety of harmful mites. Tetromethazine not only has a special effect on the eggs of mites, but also has a good effect on young mites, and also has sterilizing effect on female adult mites. A series of six tetrazines were synthesized according to the structural characteristics of Tetromethazine and the active groups on both sides of the tetrazine ring. The mite killing effect of compounds 鈪，
本文編號(hào)：2346664
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