【摘要】：基于數(shù)字離子阱技術(shù),研究了離子阱質(zhì)譜分析實(shí)驗(yàn)過(guò)程使用的碰撞氣體種類(lèi)及壓力對(duì)離子阱質(zhì)譜性能,如質(zhì)量分辨能力、信號(hào)強(qiáng)度、串級(jí)質(zhì)譜分析,以及低質(zhì)量截止效應(yīng)等的影響。實(shí)驗(yàn)過(guò)程中,在離子的激發(fā)和碰撞誘導(dǎo)解離階段,分別采用質(zhì)量數(shù)不等的氦氣(質(zhì)量數(shù)=4 amu)、氮?dú)?質(zhì)量數(shù)=28 amu)、氬氣(質(zhì)量數(shù)=40 amu)等作為碰撞氣體,以及不同的氣體壓力,研究了它們對(duì)質(zhì)譜性能的影響。結(jié)果表明,當(dāng)采用質(zhì)量數(shù)較大的氬氣作為碰撞氣體時(shí),可以有效改善低質(zhì)量數(shù)截止效應(yīng)和提高離子碰撞過(guò)程中的能量轉(zhuǎn)移效率,同時(shí)提高離子捕獲和解離效率,但是質(zhì)量分辨率會(huì)明顯降低。在獲得較高質(zhì)量分辨率方面,氦氣作為碰撞氣體時(shí)效果最好。在氣壓相同的情況下,質(zhì)量數(shù)大的碰撞氣體有利于提高串級(jí)質(zhì)譜分析效率,即獲得更多碎片離子峰和更多有關(guān)母體離子結(jié)構(gòu)的信息。
[Abstract]:Based on the digital ion trap technique, the types of collisional gases used in ion trap mass spectrometry analysis and the performance of pressure on ion trap mass spectrometry, such as mass resolution, signal intensity, cascade mass spectrometry analysis, are studied. And the effect of low quality cutoff effect. In the process of ion excitation and collision induced dissociation, helium (mass number 4 amu), nitrogen) (mass number 28 amu), argon (mass number 40 amu) was used as collision gas, and different gas pressures were used, respectively, in the process of ion excitation and collision-induced dissociation, respectively, with different mass numbers of helium (mass number of 4 amu), nitrogen gas) and mass number of 28 amu), argon (mass number of 40 amu). Their effects on the mass spectrum properties were studied. The results show that the low mass cut-off effect, energy transfer efficiency and ion capture and dissociation efficiency can be improved effectively when argon gas with large mass number is used as collision gas. But the mass resolution is significantly reduced. Helium is the most effective as collision gas in obtaining high mass resolution. Under the same pressure, the collision gas with large mass can improve the efficiency of cascade mass spectrometry, that is to say, more fragment ion peaks and more information about the structure of parent ions can be obtained.
【作者單位】： 復(fù)旦大學(xué)電子工程系;復(fù)旦大學(xué)化學(xué)系激光化學(xué)研究所;廣州禾信儀器股份有限公司;
【基金】：科技部十二五重大科學(xué)儀器設(shè)備開(kāi)發(fā)專(zhuān)項(xiàng)(No.2011YQ14015006)資助~~
【分類(lèi)號(hào)】：O657.63

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