【摘要】：針對環(huán)境污染源的早期檢測和疾病的預(yù)防與治療已經(jīng)研究開發(fā)出許多檢測技術(shù)手段,其中,熒光探針作為一種方便、靈敏、可視化的檢測技術(shù)得到了廣泛關(guān)注與認(rèn)可。大環(huán)分子熒光探針作為一類重要的熒光探針逐漸引起了研究者的關(guān)注。大環(huán)分子具有特定尺寸、可特異性配合某些基團(tuán)的空腔。因此,在設(shè)計(jì)這類熒光探針時(shí)可以充分利用大環(huán)分子的空腔優(yōu)勢。此外,大環(huán)分子容易通過化學(xué)修飾制備多種功能化衍生物,這也為設(shè)計(jì)大環(huán)熒光探針提供了更多選擇。本文回顧了大環(huán)分子熒光探針的設(shè)計(jì)策略,主要從探針的化學(xué)組成以及相互作用機(jī)理來闡述,為大環(huán)分子熒光探針的設(shè)計(jì)提供了系統(tǒng)的理論指導(dǎo)。
[Abstract]:For the early detection of environmental pollution sources and the prevention and treatment of diseases, many detection techniques have been developed. Among them, fluorescent probe as a convenient, sensitive, visual detection technology has been widely concerned and recognized. As a kind of important fluorescent probe, macromolecular fluorescence probe has attracted more and more attention. Macrocyclic molecules have a specific size and can be specifically combined with the cavities of certain groups. Therefore, the cavity advantage of macrocyclic molecules can be fully utilized in the design of these fluorescent probes. In addition, macrocyclic molecules are easily prepared by chemical modification, which provides more options for the design of macrocyclic fluorescent probes. This paper reviews the design strategy of macromolecular fluorescence probe, mainly from the chemical composition and interaction mechanism of the probe, which provides a systematic theoretical guidance for the design of macrocyclic molecular fluorescence probe.
【作者單位】： 北京化工大學(xué);
【基金】：國家自然科學(xué)基金(21574009,51521062) 北京市自然科學(xué)基金(2142026) 雙一流建設(shè)專項(xiàng)經(jīng)費(fèi)(PY201605)資助~~
【分類號】：O641.3;O657.3
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本文編號：2170123