【摘要】：采用飽和水溶液法制備了大豆苷元分別與兩種氨基修飾β-環(huán)糊精(ACD)即單-6-氨基-β-環(huán)糊精(NCD)和單-6-乙二胺基-β-環(huán)糊精(ENCD)的固體包合物,并獲得最佳包合條件:大豆苷元與環(huán)糊精投料比為3:1(n/n),攪拌時(shí)間為72 h,分別獲得83%和67%的產(chǎn)率。利用X-射線粉末衍射和熱重分析對其進(jìn)行了表征,證實(shí)了兩種包合物的形成。利用Job's曲線法確定了主客體的包合比為1:1,并利用熒光光譜滴定分析測得其包合穩(wěn)定常數(shù)KS分別為899.2和203.8 L/mol。水溶性實(shí)驗(yàn)表明,通過與NCD和ENCD形成包合物,25℃下大豆苷元在水中的溶解度由原來的8.31μg/mL增至15.2和13.2 mg/mL,分別提高了約1800和1500倍。
[Abstract]:The solid inclusion complexes of daidzein with two kinds of amino-modified 尾 -cyclodextrin (ACD) (mono-6-amino-beta-cyclodextrin (NCD) and mono-6-ethylenediamyl- 尾 -cyclodextrin (ENCD) were prepared by saturated aqueous solution method. The optimum inclusion conditions were obtained as follows: the ratio of daidzein to cyclodextrin was 3:1 (n / n), the stirring time was 72 h, and the yields of 83% and 67% were obtained respectively. It was characterized by X-ray powder diffraction and thermogravimetric analysis, and the formation of two inclusion complexes was confirmed. The inclusion ratio of host and guest is 1: 1 by Job's curve method, and the inclusion stability constant KS is 899.2 and 203.8 L / mol, respectively. The solubility of daidzein in water was increased from 8.31 渭 g/mL to 15.2,13.2 mg / mL by forming inclusion complexes with NCD and ENCD at 25 鈩，

本文編號：2146697