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  本文選題：球形羥基氧化鐵 + 量子點��； 參考：《安徽師范大學》2017年碩士論文

【摘要】：我們通過不同合成條件的控制,借助納米粒子的自組裝,制備出尺寸可調(diào)的球形羥基氧化鐵(Fe OOH)超級納米粒子。此外,熒光探針由于其好的靈敏性、簡單性以及多功能性,在生物醫(yī)療實驗、疾病標志物的診斷和有毒物質(zhì)的檢測方面,被廣泛應用。借助磁性納米粒子的自組裝,結(jié)合磁性分離及等離子體增強熒光,以量子點為信號輸出,構(gòu)建了一種從完全的“零背景”到“真實信號放大”的傳感模式,這種模式打破了傳統(tǒng)的“turn-on”模式的上限與下限。對于分析物透明質(zhì)酸酶的檢測,相比于傳統(tǒng)的熒光模式,其靈敏度提高了10~4-10~6倍。論文主要包括以下四個章節(jié):第一章為緒論,主要綜述了FeOOH納米材料、半導體納米材料以及磁性材料的概述、合成以及應用進展。并提出了待解決的問題和潛在應用,基于此提出了本論文的工作設想。第二章通過回流時間、預先p H值以及原料的量的控制,成功制備出不同尺寸的球形Fe OOH超級納米粒子。第三章利用量子點(QDs)、磁性粒子(Fe_3O_4 NPs)以及貴金屬納米粒子(Ag NPs)的易于修飾和功能化的特點,基于磁性分離與等離子體增強效應,實現(xiàn)從零背景到信號放大的超“turn-on”熒光傳感模式。以量子點為信號輸出,高靈敏度地檢測了尿液和血清中的癌癥標志物、水解酶---透明質(zhì)酸酶。第四章為本篇論文的創(chuàng)新之處以及工作展望。對已經(jīng)開展的工作進行了總結(jié),并展望了后續(xù)的研究工作。
[Abstract]:The spherical ferric hydroxide (FeOOH) superparticles with adjustable size were prepared by the control of different synthesis conditions and self-assembly of nanoparticles. In addition, fluorescent probes are widely used in biomedical experiments, diagnosis of disease markers and detection of toxic substances due to their good sensitivity, simplicity and versatility. With the help of self-assembly of magnetic nanoparticles, combined with magnetic separation and plasma-enhanced fluorescence, a sensing mode from "zero background" to "real signal amplification" was constructed by using quantum dots as signal output. This model breaks the upper and lower limits of the traditional "turn-on" model. The sensitivity of hyaluronidase was 104-106 times higher than that of traditional fluorescence mode. The thesis mainly includes four chapters as follows: the first chapter is the introduction, which mainly summarizes the progress of FeOOH nanomaterials, semiconductor nanomaterials and magnetic materials, synthesis and application of FeOOH nanomaterials. The problems to be solved and the potential applications are put forward, and based on this, the working assumption of this paper is put forward. In the second chapter, the spherical FeOOH superparticles with different sizes were successfully prepared by controlling the reflux time, the pre-pH value and the amount of raw materials. In chapter 3, based on magnetic separation and plasma-enhanced effect, the properties of quantum dots (QDs), magnetic particles (FeSs) and noble metal nanoparticles (Ag NPs) are easily modified and functionalized. The super-" turn-on "fluorescence sensing mode from zero background to signal amplification is realized. Using quantum dots as signal output, the cancer marker, hydrolase-hyaluronidase, in urine and serum was detected with high sensitivity. The fourth chapter is the innovation of this paper and work prospects. The work has been summarized, and the future research work is prospected.
【學位授予單位】：安徽師范大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：O657.3;TB383.1

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本文編號：2061640