本文選題：氮雜環(huán)卡賓 + Strecker反應(yīng)　； 參考：《有機化學》2017年04期

【摘要】：以四氫呋喃為溶劑,氮雜環(huán)卡賓為催化劑,進行了氰基甲酸乙酯和亞胺的Strecker反應(yīng)研究.實驗中考察了催化劑的種類、用量及溶劑對反應(yīng)的影響,確定了最優(yōu)反應(yīng)條件.結(jié)果顯示氰基甲酸乙酯與芳香亞胺、脂肪亞胺都能發(fā)生Strecker反應(yīng),最終合成了14個α-氨基腈衍生物,產(chǎn)物產(chǎn)率最高達到93%.該反應(yīng)具有操作簡單,條件溫和,產(chǎn)率高及環(huán)境友好等優(yōu)點.
[Abstract]:The Strecker reaction of ethyl cyanate and imine was studied using tetrahydrofuran as solvent and heterocyclic carbene as catalyst. The effects of catalyst type, dosage and solvent on the reaction were investigated, and the optimum reaction conditions were determined. The results showed that 14 偽 -aminonitrile derivatives were synthesized by Strecker reaction of ethyl cyanate with aromatic imines and aliphatic imines. The highest yield of the products was 933%. The reaction has the advantages of simple operation, mild conditions, high yield and environmental friendliness.
【作者單位】： 石河子大學化學化工學院新疆兵團化工綠色過程重點實驗室-省部共建國家重點實驗室培育基地;
【基金】：國家自然科學基金(No.21262027)資助項目~~
【分類號】：O621.251
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本文編號：2060205