本文選題：殼聚糖 + N-琥珀�；�　； 參考：《長春大學》2017年碩士論文

【摘要】：殼聚糖作為可降解和再生的高分子材料而備受關注,而殼聚糖固有特性的不足限制了其應用,各種改性手段被用來對殼聚糖結構中活潑的多羥基和氨基官能團進行修飾,以增強殼聚糖的應用性。近年來,納米材料的研究成為熱點,殼聚糖納米材料與其他人工高分子材料相比優(yōu)點較為突出。同時經由殼聚糖為主要原料制備的膜材料在農業(yè)、醫(yī)藥、環(huán)保等方面被廣泛應用。本文以殼聚糖為研究對象,通過對其改性、納米化、膜處理后,進一步優(yōu)化制備工藝從而提高其應用價值,具體研究內容如下:(1)本論文通過丁二酸酐與殼聚糖發(fā)生�；磻�,由IR光譜圖分析得證酰化反應最終在殼聚糖分子結構的N-位成功引入琥珀�；�,在二甲基亞砜體系中制備獲得改性的N-琥珀酰殼聚糖。制備得到N-琥珀酰殼聚糖的脫乙酰度達到0.63。溶解性實驗表明N-琥珀酰殼聚糖的水溶解性能明顯強于殼聚糖。(2)利用殼聚糖和實驗獲得的N-琥珀酰殼聚糖為原料,依據離子誘導法獲得殼聚糖納米和N-琥珀酰殼聚糖納米粒,對制備過程中的影響因素進行了實驗分析。并對兩種納米粒子同時進行表征后對比研究性狀不同之處,實驗條件下制備的N-琥珀酰殼聚糖納米粒體系較為穩(wěn)定,從電鏡照片可觀察出納米粒的形態(tài)完整,分散性良好,平均粒徑為195nm。(3)實驗利用流延法分別獲得了殼聚糖膜、N-琥珀酰殼聚糖膜。實驗以機械性能為指標,獲得了殼聚糖膜的最優(yōu)制取工藝:殼聚糖濃度2%、堿處理時間3h、烘干溫度50℃、烘干時間4h。紅外光譜表明甘油的加入并沒有改變殼聚糖分子的內部結構,但甘油可明顯改善膜的延展性,從而最大限度地在復合膜中保留了殼聚糖良好的生物特性。
[Abstract]:Chitosan, as a biodegradable and regenerated polymer material, has attracted much attention. However, its application is limited by the inherent characteristics of chitosan. Various modification methods have been used to modify the active polyhydroxyl and amino functional groups in the structure of chitosan. To enhance the application of chitosan. In recent years, the research of nano-materials has become a hot spot. Chitosan nano-materials have more advantages than other artificial polymer materials. Meanwhile, membrane materials prepared by chitosan are widely used in agriculture, medicine, environmental protection and so on. In this paper, chitosan was used as the research object. After modification, nanocrystalline and membrane treatment, the preparation process was further optimized to improve its application value. The specific research contents were as follows: (1) the acylation reaction between chitosan and succinic anhydride was carried out in this paper. The IR spectra showed that the succinyl group was successfully introduced into the N-site of chitosan molecular structure and the modified N-succinyl chitosan was prepared in the system of dimethyl sulfoxide (DMSO). The degree of deacetylation of N-succinyl chitosan was 0.63. The solubility test showed that the solubility of N- succinyl chitosan was better than that of chitosan. (2) chitosan nanoparticles and N- succinyl chitosan nanoparticles were obtained by ion induction method using chitosan and N- succinyl chitosan as raw materials. The influencing factors in the preparation process were analyzed experimentally. The N- succinyl chitosan nanoparticles prepared under the experimental conditions were stable, and the morphology and dispersity of the nanocrystalline grains could be observed by electron microscope photographs. The average particle size was 195 nm. (3) the chitosan membrane was obtained by the method of flow extension, and the N-succinyl chitosan membrane was obtained. The optimum preparation process of chitosan membrane was obtained by taking mechanical properties as index: chitosan concentration 2, alkali treatment time 3 h, drying temperature 50 鈩，

本文編號：2055165