本文選題：透明質(zhì)酸 + 雙親大分子　； 參考：《江南大學(xué)》2017年碩士論文

【摘要】：大分子自組裝是制備功能性納米顆粒的一種有效手段,2005年Armes團(tuán)隊(duì)首次以大分子自組裝制備聚合物膠體粒子作為顆粒乳化劑,用于穩(wěn)定油/水乳狀液,并逐漸成為研究熱點(diǎn)。有別于聚合物顆粒乳化劑,生物基顆粒乳化劑因其可降解、環(huán)境友好等特性迅速進(jìn)入人們的視線。透明質(zhì)酸(HA)作為天然大分子之一,具有良好生物相容性、易降解性、卓越保濕性等優(yōu)勢(shì),在許多領(lǐng)域有不可估量的應(yīng)用前景。但HA自身親水性強(qiáng)、功能性單一的缺點(diǎn)限制了它的應(yīng)用范圍,因此通常用物理或化學(xué)方法對(duì)其進(jìn)行改性,以改變HA的物化性質(zhì)賦予其更多功能。本論文利用光敏單體疏水改性HA,研究改性HA在選擇性溶劑中的自組裝行為,并且以改性HA膠體粒子為顆粒乳化劑,探究其在油水界面的二次組裝行為;最后,選取合適的改性HA膠體粒子用于化妝品膏霜實(shí)現(xiàn)了HA顆粒乳化劑的實(shí)際應(yīng)用。本論文主要由以下三個(gè)部分組成:1、肉桂酸改性透明質(zhì)酸自組裝膠體粒子制備及其乳化性能研究本章利用光敏單體肉桂酸(CA)疏水改性HA,制得雙親性的HA衍生物HA-CA,在選擇性溶劑(DMSO/H2O)中可自組裝得到HA-CA膠體粒子。通過紅外光譜、核磁共振氫譜和紫外譜圖確定HA-CA的化學(xué)結(jié)構(gòu)和性質(zhì);通過紫外分光光度計(jì)追蹤HA-CA的組裝過程,利用納米粒度及Zeta電位分析儀、透射電鏡(TEM)、視頻光學(xué)接觸角測(cè)量?jī)x對(duì)HA-CA膠體粒子的結(jié)構(gòu)、形貌、親疏水性等進(jìn)行了表征;以HA-CA膠體粒子為顆粒乳化劑研究其在油水界面的二次組裝行為,考察了水相p H、鹽濃度、油相類型等因素對(duì)膠體粒子在油水界面組裝行為的影響,并通過苯乙烯油相固化法表征了膠體粒子在油水界面的形貌;通過細(xì)胞實(shí)驗(yàn)研究膠體粒子以及所制備乳液的細(xì)胞相容性。結(jié)果顯示:HA-CA在UVB波段具有紫外吸收;HA-CA膠體粒子作為顆粒乳化劑可制備O/W型Pickering乳液,且膠體粒子具有一定的保濕性和良好的細(xì)胞相容性。2、香豆素衍生物改性透明質(zhì)酸自組裝膠體粒子制備及其乳化性能研究本章利用香豆素衍生物7-(2-羥基乙氧基)-4-甲基香豆素(HEMC)作為光敏單體疏水改性HA獲得HA衍生物HA-HEMC,雙親性HA-HEMC在選擇性溶劑(DMSO/H2O)中可自組裝形成HA-HEMC膠體粒子。通過紅外光譜、核磁共振氫譜以及紫外譜圖對(duì)HA-HEMC的化學(xué)結(jié)構(gòu)和性質(zhì)進(jìn)行表征;通過紫外分光光度計(jì)研究HA-HEMC的組裝行為,利用動(dòng)態(tài)激光光散射(DLS)、納米粒度及Zeta電位分析儀、透射電鏡(TEM)等對(duì)HA-HEMC膠體粒子的結(jié)構(gòu)、形貌和性質(zhì)進(jìn)行了表征;將HA-HEMC膠體粒子作為顆粒乳化劑穩(wěn)定油水界面,考察了膠體粒子取代度(DS)、質(zhì)量濃度、油相類型、水相pH、鹽濃度等對(duì)膠體粒子穩(wěn)定油水界面的影響,并通過GTT法表征膠體粒子在油水界面的形貌。結(jié)果顯示:HA-HEMC在UVA和UVB波段均具有紫外吸收;該膠體粒子能夠在較寬pH范圍內(nèi)(3~11)穩(wěn)定O/W型Pickering乳液,且所得乳液有良好的耐鹽性;此外,HA-HEMC膠體粒子還能夠穩(wěn)定多種油-水體系。3、HA-HEMC自組裝膠體粒子作為顆粒乳化劑制備防曬膏霜的應(yīng)用研究本章選取HA-HEMC膠體粒子作為研究對(duì)象,通過紫外分光光度計(jì)檢測(cè)膠體粒子的光敏性;通過稱重法檢測(cè)膠體粒子的保濕性;通過細(xì)胞實(shí)驗(yàn)研究膠體粒子的生物相容性。將HA-HEMC膠體粒子加入化妝品膏霜中,通過感官評(píng)價(jià)、pH值測(cè)定、穩(wěn)定性測(cè)試等考察了化妝品膏霜的品質(zhì);通過紫外透過率測(cè)試評(píng)價(jià)化妝品膏霜的防曬性能。結(jié)果顯示:HA-HEMC膠體粒子具有光敏性、保濕性以及細(xì)胞相容性,是一種新型的防曬化妝品原料,且隨著膠體粒子加入量的增加膏霜的品質(zhì)及防曬性能都得到提升。
[Abstract]:Macromolecule self-assembly is an effective means to prepare functional nanoparticles. In 2005, Armes team prepared polymer colloid particles as particle emulsifier for the first time, used to stabilize oil / water emulsion, and gradually became a hot spot. As one of the large natural molecules, hyaluronic acid (HA), as one of the large natural molecules, has the advantages of good biocompatibility, easy degradation and excellent moisture retention, and has an inestimable application prospect in many fields. However, HA has a strong hydrophilic property and a single functional disadvantage, so it is usually used in physics. Modify the physical and chemical properties of HA by chemical method to change its physical and chemical properties. In this paper, the self assembly behavior of modified HA in the selective solvent was studied by using the hydrophobic modified HA, and the modified HA colloid particles were used as particle emulsifier to explore the two assembly behavior of the modified HA particles in the oil and water surface. Finally, the appropriate modification was selected. The application of HA colloid particles to cosmetic cream has realized the practical application of HA particle emulsifier. This paper is mainly composed of three parts: 1, preparation and emulsification of self assembled colloidal particles of cinnamic acid modified hyaluronic acid in this chapter, a amphiphilic HA derivative HA-CA is prepared by using photosensitive monomer cinnamic acid (CA) hydrophobic modified HA. HA-CA colloid particles can be self assembled by self assembly in the sex solvent (DMSO/H2O). The chemical structure and properties of HA-CA are determined by IR, NMR and UV spectra. The UV spectrophotometer is used to track the assembly process of HA-CA, using the nanoscale and Zeta potential analyzer, transmission electron microscopy (TEM), and the video optical contact angle measuring instrument to HA-CA The structure, morphology, hydrophobicity of the colloid particles were characterized, and the two assembly behavior of HA-CA colloid particles as particle emulsifier on the oil and water interface was studied. The effects of the water phase P H, salt concentration and oil phase type on the assembly behavior of colloidal particles on the oil and water interface were investigated, and the colloidal particles were characterized by the styrene oil phase curing method. The morphology of the seed in the oil and water interface; the cell compatibility of colloid particles and the prepared emulsion by cell experiment. The results show that HA-CA has UV absorption in the UVB band; HA-CA colloid particles can be used as particle emulsifier to prepare O/W Pickering emulsion, and the colloid particles have a definite moisture retention and good cellular compatibility.2, sweet bean The preparation and emulsification properties of self assembled colloidal particles of the modified hyaluronic acid derivatives were studied in this chapter, using the coumarin derivative 7- (2- hydroxy ethoxy) -4- methyl coumarin (HEMC) as the hydrophobic modified HA of the photosensitive monomer to obtain the HA derivative HA-HEMC, and the amphiphilic HA-HEMC can be self-assembled to form HA-HEMC colloid particles in the selective solution (DMSO/H2O). The chemical structure and properties of HA-HEMC were characterized by IR, NMR and UV spectra, and the assembly behavior of HA-HEMC was studied by UV spectrophotometer. The structure, morphology and properties of HA-HEMC colloid particles were studied by dynamic laser light scattering (DLS), nanoscale and Zeta potential analyzer, transmission electron microscope (TEM) and so on. The effects of colloid particle substitution (DS), mass concentration, oil phase type, water phase pH and salt concentration on the stability of oil and water interface were investigated by using colloidal particles as particle emulsifier to stabilize oil water interface, and the morphology of colloid particles in oil and water interface was characterized by GTT method. The results showed that HA-HEMC was in both UVA and UVB bands. The results showed that HA-HEMC was both in UVA and UVB bands. UV absorption, the colloid particles can stabilize O/W Pickering emulsion in a wide pH range (3~11), and the emulsion has good salt tolerance. In addition, HA-HEMC colloid particles can also stabilize a variety of oil water system.3, HA-HEMC self assembled colloid particles as particle emulsifier to prepare sunscreen cream for the application of HA-HEMC colloid As the object of study, the photosensitivity of colloid particles was detected by ultraviolet spectrophotometer. The moisture retention of colloid particles was detected by weighing method, and the biocompatibility of colloid particles was studied by cell experiment. HA-HEMC colloid particles were added to cosmetics cream, and cosmetics were examined by sensory evaluation, pH value determination, stability test and so on. The quality of the cream is evaluated by the UV transmittance test. The results show that the HA-HEMC colloid particles are photosensitive, moisturizing and cellular compatibility. It is a new type of raw material for sunscreen cosmetics, and as the addition of colloid particles increases the quality of cream and the performance of sunscreen are improved.
【學(xué)位授予單位】：江南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：O629.9;TQ658.24

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