本文選題：雙模板 + 分子印跡復(fù)合膜　； 參考：《西南交通大學(xué)》2017年碩士論文

【摘要】：分子印跡膜兼具分子印跡技術(shù)與膜分離技術(shù)雙重優(yōu)點(diǎn),但由于有機(jī)膜的機(jī)械強(qiáng)度較小,在分離過程中受壓容易使印跡孔穴空間變形和互補(bǔ)官能團(tuán)位置失穩(wěn),使得其分離效率大大降低。為了提高膜的機(jī)械性能和水通量,在制備過程中摻雜入無機(jī)納米粒子制備出有機(jī)—無機(jī)雜化膜。本文使用紫外光引發(fā)原位聚合的方法,以PVDF為支撐膜,將無機(jī)納米材料摻雜入鑄膜液中,制備出含有無機(jī)納米材料的阿魏酸分子印跡復(fù)合膜。利用紅外光譜和掃描電鏡測試了膜的結(jié)構(gòu)和表面形貌,發(fā)現(xiàn)了納米粒子是以純物理方式共混的,且都分散在孔的周圍,有利于維持膜的孔穴結(jié)構(gòu)。通過平板超濾裝置研究了分子印跡復(fù)合膜的分離性能、水通量和承壓能力,研究結(jié)果表明改性后的分子印跡復(fù)合膜在保持高分離效率的前提下,承壓能力和水通量都有了明顯的改善。同時,實(shí)驗(yàn)發(fā)現(xiàn)添加0.5wt%-18 nm TiO2的改性膜性能最好,其承壓能力在0.4 Mpa以上,分離因子在3.4左右,水通量為6696L·m-2·h-1。在前期實(shí)驗(yàn)的基礎(chǔ)上,本文采用不同的方法制備出雙模板分子印跡復(fù)合膜,并采用多種方式對膜的各項(xiàng)性能進(jìn)行表征。本文探討了以α-甲基丙烯酸為功能單體,乙二醇二甲基丙烯酸酯為交聯(lián)劑,阿魏酸和肉桂酸為雙模板分子,偶氮二異丁腈為引發(fā)劑引發(fā)聚合反應(yīng),并采用共混法摻雜入納米材料改善膜的機(jī)械強(qiáng)度和水通量,從而合成了具有高通量和高選擇性的雙模板分子印跡復(fù)合膜。本文探究了無機(jī)納米材料的種類及其含量、引發(fā)劑的含量、模板分子與功能單體的比值以及合成方法(一步法或者兩步法)對雙模板分子印跡復(fù)合膜的性能的影響。研究發(fā)現(xiàn)合成的最優(yōu)條件為:添加的納米材料為18 nmTiO2,添加含量為1wt%,引發(fā)劑的含量為0.3 g,采用一步法合成,功能單體與模板分子的比值(F/T)為1:3。采用上述條件合成的雙模板分子印跡復(fù)合膜對模板分子阿魏酸和肉桂酸的透過率均處在100%左右,與此同時對類似物咖啡酸、丁香酸的透過率也達(dá)到了 100%左右。然而對相對分子量大小相似,而結(jié)構(gòu)差別比較大的葡萄糖的透過率處在60%左右。綜上可知,制備的雙模板分子印跡復(fù)合膜可特異性分離模板分子以及類似物,然而對結(jié)構(gòu)相差比較大的物質(zhì)具有較低的分離效率�？梢�,雙模板分子印跡膜可專一性的識別同一類物質(zhì),因此,可將其應(yīng)用于某些中藥活性成分的選擇富集和分離、食物中有毒物質(zhì)的檢測等。
[Abstract]:The molecularly imprinted membrane has the advantages of both molecular imprinting and membrane separation. However, due to the small mechanical strength of the organic membrane, it is easy to be subjected to pressure during the separation process to make the space deformation of the imprinted holes and the position of complementary functional groups unstable. The separation efficiency is greatly reduced. In this paper, in order to prepare ferulic acid molecularly imprinted composite films containing inorganic nanomaterials, the inorganic nanomaterials were doped into the casting solution with PVDF as the supporting membrane by the method of in situ polymerization initiated by ultraviolet light. The structure and surface morphology of the films were measured by infrared spectroscopy and scanning electron microscopy. It was found that the nanoparticles were blended in a pure physical manner and were dispersed around the pores, which was conducive to maintaining the pore structure of the films. The separation performance, water flux and pressure bearing capacity of the molecularly imprinted composite membrane were studied by a flat plate ultrafiltration device. The results showed that the modified molecularly imprinted composite membrane maintained high separation efficiency. Both the pressure bearing capacity and the water flux have been significantly improved. At the same time, it was found that the modified membrane with 0.5wt%-18 nm TiO2 had the best performance, its pressure bearing capacity was more than 0.4 Mpa, the separation factor was about 3.4, and the water flux was 6696 L m-2 h-1. On the basis of previous experiments, the double template molecularly imprinted composite membranes were prepared by different methods, and the properties of the membranes were characterized in various ways. The polymerization was initiated with 偽 -methacrylic acid as functional monomer, ethylene glycol dimethacrylate as crosslinking agent, ferulic acid and cinnamic acid as double template molecules and azodiisobutyronitrile as initiator. The high throughput and high selectivity double template molecularly imprinted composite membranes were synthesized by blending nanomaterials to improve the mechanical strength and water flux of the membranes. The effects of inorganic nanomaterials and their contents, initiator content, the ratio of template molecules to functional monomers and synthesis methods (one-step or two-step) on the properties of double-template molecularly imprinted composite films were investigated. It was found that the optimum conditions of synthesis were as follows: the addition of nano-materials was 18 nm TIO _ 2, the content of the initiator was 0.3 g, the ratio of functional monomer to template was 1: 3, the content of initiator was 0.3 g, the ratio of functional monomer to template was 1: 3. The transmissivity of the double template molecularly imprinted composite membrane to the template molecules ferulic acid and cinnamic acid is about 100%, and the transmittance of the analogue caffeic acid and eugenic acid is about 100%. However, the transmittance of glucose with similar molecular weight and structure is about 60%. It can be concluded that the double template molecularly imprinted composite membrane can specifically isolate template molecules and analogues, but it has a low separation efficiency for substances with large structural differences. Therefore, it can be applied to the selection, enrichment and separation of some traditional Chinese medicine active components, the detection of toxic substances in food and so on.
【學(xué)位授予單位】：西南交通大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：O631.3

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 秦世麗;蘇立強(qiáng);王鵬;;磺胺類復(fù)合模板分子印跡聚合物的制備及其應(yīng)用[J];分析試驗(yàn)室;2016年05期

2 王素素;張?jiān)?李輝;;Zn~(2+)配位雙模板印跡聚合物的制備表征及同時萃取升麻中的阿魏酸和咖啡酸[J];化工進(jìn)展;2016年04期

3 蘇立強(qiáng);陳琳;李繼嬌;王丹丹;;塑化劑類雙模板分子印跡聚合物的制備及其性能研究[J];理化檢驗(yàn)(化學(xué)分冊);2015年12期

4 韋壽蓮;劉玲;黎京華;汪洪武;劉永;;雙分子印跡聚合物微球選擇固相萃取環(huán)境和食品樣品中壬基酚和雙酚A[J];分析化學(xué);2015年01期

5 徐琴;王召占;孟慧琴;呂寧;牛增元;葉曦雯;翟麗娜;;雙酚A環(huán)氧衍生物分子印跡聚合物的制備及其吸附性能研究[J];食品安全質(zhì)量檢測學(xué)報;2014年12期

6 楊方威;馮敘橋;曹雪慧;李萌萌;段小明;韓鵬祥;;膜分離技術(shù)在食品工業(yè)中的應(yīng)用及研究進(jìn)展[J];食品科學(xué);2014年11期

7 王嬌;王樞;陳洪巖;王韜;;阿魏酸分子印跡復(fù)合膜的制備及性能[J];功能高分子學(xué)報;2013年02期

8 楊九凌;祝曉玲;李成文;徐文瑞;李學(xué)軍;;咖啡酸及其衍生物咖啡酸苯乙酯藥理作用研究進(jìn)展[J];中國藥學(xué)雜志;2013年08期

9 王華;劉艷飛;彭東明;王福東;魯曼霞;;膜分離技術(shù)的研究進(jìn)展及應(yīng)用展望[J];應(yīng)用化工;2013年03期

10 陳余;;膜分離技術(shù)在中藥提取分離中的應(yīng)用[J];化學(xué)工程與裝備;2013年02期

，

本文編號：1958285