本文選題：葡萄糖二酸 + 樹脂��； 參考：《遼寧大學(xué)》2016年碩士論文

【摘要】：葡萄糖二酸是一種天然、無毒的化合物,少量產(chǎn)生于哺乳動(dòng)物及人體的分泌物和一些植物中。葡萄糖二酸及其衍生物在降低膽固醇、糖尿病的治療等方面發(fā)揮作用逐漸受到醫(yī)學(xué)界的重視。葡萄糖二酸對陽離子有較強(qiáng)的螯合性,可以完美的替代洗滌劑中的磷酸鹽。葡萄糖二酸在聚合物單體方面顯示出巨大的潛能,例如合成超支化聚酯和生物可降解的新型尼龍。所以在2004年葡萄糖二酸及其衍生物被美國能源部確定為“最具有價(jià)值的生物煉制產(chǎn)品”。傳統(tǒng)生產(chǎn)葡萄糖二酸的方法是HN03氧化法,該方法存在試劑耗費(fèi)量大,污染環(huán)境等缺點(diǎn)已不能滿足實(shí)際生產(chǎn)需求。生物法生產(chǎn)葡萄糖二酸有降低原料的損耗、提高產(chǎn)品純度等優(yōu)勢,作為化學(xué)替代法來合成葡萄糖二酸受到越來越多的關(guān)注。目前生物法合成葡萄糖二酸的工作仍處于實(shí)驗(yàn)室研究階段,同時(shí)分離提取的方法上還沒研究。因此,如何對生物法制備葡萄糖二酸的分離方法有待進(jìn)一步研究。本論文分別應(yīng)用陰離子交換樹脂、中性樹脂和活性炭對水溶液中葡萄糖二酸的吸附性能進(jìn)行研究,并對各實(shí)驗(yàn)參數(shù)進(jìn)行了優(yōu)化選擇。研究主要結(jié)果如下：首先通過靜態(tài)吸附研究,篩選了合理的樹脂分離條件。在298K和pH=2.01、3.90和6.06條件下,對7種國產(chǎn)離子交換樹脂靜態(tài)吸附篩選,篩選出335樹脂作為最佳吸附離子交換樹脂(Kf=135.6751mg·g~(-1)),實(shí)驗(yàn)中最大吸附量可達(dá)350mg·g~(-1),吸附等溫線在pH=3.90和298 K條件下滿足Freundlich模型,該吸附過程屬于優(yōu)惠吸附。同時(shí)還研究了Amberlite XAD4、Amberlite XAD1600N中性樹脂和活性炭吸附水溶液中的葡萄糖二酸,研究表明在pH=2.01和298 K時(shí)Amberlite XAD4樹脂吸附效果最好(Kf=94.38 mg·g~(-1)),并且Freundlich方程可較好的描述葡萄糖二酸在Amberlite XAD4樹脂上的吸附平衡,該吸附過程屬于優(yōu)惠吸附。陰離子交換樹脂的吸附效果要優(yōu)于中性樹脂和活性炭的吸附效果。根據(jù)熱力學(xué)計(jì)算得到吸附過程中的吸附自由能變?chǔ),結(jié)果表明實(shí)驗(yàn)選取的10種吸附劑對水溶液中葡萄糖二酸吸附過程的ΔG0,該反應(yīng)過程可自發(fā)進(jìn)行。在葡萄糖二酸的動(dòng)力學(xué)研究中,分別采用準(zhǔn)一級動(dòng)力學(xué)模型和準(zhǔn)二級動(dòng)力學(xué)模型考察了7種離子交換樹脂對葡萄糖二酸吸附動(dòng)力學(xué),擬合結(jié)果表明準(zhǔn)二級動(dòng)力學(xué)模型和實(shí)驗(yàn)數(shù)據(jù)之間有較好的相關(guān)性。離子交換樹脂對葡萄糖二酸的吸附速率由擴(kuò)散過程控制。在上樣液流速分別為1 mL·min~(-1)和2 mL·min~(-1)條件下,探究了335樹脂和711樹脂動(dòng)態(tài)吸附柱實(shí)驗(yàn)。結(jié)果表明pH=3.90,吸附溫度為298 K時(shí),335樹脂優(yōu)于711樹脂；上樣流速1 mL·min~(-1)優(yōu)于2 mL·min~(-1).
[Abstract]:Gluconic acid is a natural, non-toxic compound produced in small quantities in mammalian and human secretions and in plants. Gluconic acid and its derivatives play an important role in reducing cholesterol and treating diabetes mellitus. Gluconic acid has strong chelating ability to cationic acid and can be used as a perfect substitute for phosphates in detergents. Gluconic acid has great potential in polymer monomers, such as hyperbranched polyester and new biodegradable nylon. So in 2004, Glucopolylic acid and its derivatives were identified as "the most valuable Bio-Refining products" by the US Department of Energy. The traditional method of producing gluconic acid is HN03 oxidation method, which has many disadvantages, such as high reagent consumption and environmental pollution. The production of gluconic acid by biological method has the advantages of reducing the loss of raw materials and improving the purity of the product. As a chemical substitute method, the synthesis of gluconic acid has attracted more and more attention. At present, the biosynthesis of gluconic acid by biological method is still in the laboratory stage, and the method of separation and extraction has not been studied. Therefore, how to separate the preparation of Gluconic acid by biological method needs further study. In this paper, the adsorption properties of gluconic acid in aqueous solution were studied by anion exchange resin, neutral resin and activated carbon, and the experimental parameters were optimized. The main results are as follows: firstly, the reasonable separation conditions of resin were screened by static adsorption. Under the conditions of 298K, pH 2.01 ~ 3.90 and 6.06, the static adsorption of seven kinds of domestic ion-exchange resins was screened, and 335 resin was selected as the best adsorption ion-exchange resin. The maximum adsorption capacity was up to 350mg ~ (-1), and the isotherm of adsorption met the Freundlich model at pH=3.90 and 298K, and the adsorption isotherms were obtained at 298K and 298K, respectively, and the adsorption isotherms met the Freundlich model under the conditions of pH=3.90 and 298K. The adsorption process belongs to preferential adsorption. The adsorption of gluconic acid in aqueous solution by Amberlite XAD4 Amberlite XAD1600N neutral resin and activated carbon was also studied. The results show that the adsorption effect of Amberlite XAD4 resin is the best at pH=2.01 and 298K, and the Freundlich equation can describe the adsorption equilibrium of Glucopolylic acid on Amberlite XAD4 resin, which is a preferential adsorption process. The adsorption effect of anion exchange resin is better than that of neutral resin and activated carbon. According to the thermodynamic calculation, the adsorption free energy change 螖 G was obtained. The results showed that the adsorption process of gluconic acid in aqueous solution by 10 kinds of adsorbents selected in the experiment was 螖 G 0, and the reaction process could be carried out spontaneously. In the kinetic study of gluconic acid, the adsorption kinetics of 7 kinds of ion exchange resins for gluconic acid was investigated by using quasi first order kinetic model and quasi second order kinetic model, respectively. The fitting results show that there is a good correlation between the quasi-secondary kinetic model and the experimental data. The adsorption rate of Glucopolylic acid by ion exchange resin is controlled by diffusion process. At the flow rate of 1 mL / min ~ (-1) and 2 mL / min ~ (-1), the dynamic adsorption column experiments of 335 resin and 711 resin were investigated. The results showed that when pH was 3.90, adsorption temperature was 298K, the resin was superior to 711 resin, and the flow rate of sample was 1 mL / min ~ (-1), which was better than 2 mL / min ~ (-1) 路min ~ (-1).
【學(xué)位授予單位】：遼寧大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：TQ28;O647.3

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