本文選題：卷曲納米技術(shù) + 微引擎�。� 參考：《東南大學(xué)》2017年博士論文

【摘要】：在微型芯片上操縱并檢測(cè)分子旨在實(shí)現(xiàn)分子檢測(cè)的簡(jiǎn)便化、低成本化和高穩(wěn)定性,受到生物分析、光流控等領(lǐng)域的研究者們的高度重視。表面增強(qiáng)拉曼散射(SERS)光譜利用SERS效應(yīng)收集被檢測(cè)分子的“指紋譜”,是一種用于探測(cè)和鑒定微量分子的有力而靈敏的分析工具。利用SERS光譜進(jìn)行化學(xué)生物單分子檢測(cè),發(fā)展趨勢(shì)逐漸傾向于對(duì)基底改性和與其它平臺(tái)整合,實(shí)現(xiàn)多功能化、實(shí)用性強(qiáng)的一體式檢測(cè)系統(tǒng)。本工作利用卷曲納米技術(shù)制備多層材料的微米管,結(jié)合其幾何結(jié)構(gòu)并進(jìn)行表面修飾,使其具有SERS特性。此外,微米管狀結(jié)構(gòu)可作為微引擎,成為運(yùn)輸分子的有效載體,用于流體中化學(xué)生物分子的收集與檢測(cè),為其在生物分析領(lǐng)域中提供巨大的應(yīng)用潛力。論文主要工作及成果如下:1.利用卷曲納米技術(shù)制備Au/SiO/Ti/Ag催化微引擎,多層材料的選取是為了滿足多功能性的要求。使用紫外光刻或金屬掩膜版的方法設(shè)計(jì)納米薄膜的形狀,并通過在特定位置引入刻蝕劑來實(shí)現(xiàn)納米薄膜的定向卷曲,從而得到不同形狀的微引擎。通過改變納米薄膜的厚度來影響薄膜的應(yīng)力梯度,實(shí)現(xiàn)Au/SiO/Ti/Ag微引擎管徑的調(diào)控。此外,改變沉積納米薄膜的襯底表面結(jié)構(gòu),可制備表面具有納米結(jié)構(gòu)的微引擎。2.由于Au本身優(yōu)異的SERS活性以及催化微引擎表面粗糙的納米結(jié)構(gòu),微引擎表現(xiàn)出優(yōu)異的SERS特性。利用時(shí)域有限差分(FDTD)方法建立模型,對(duì)催化微引擎的表面電磁場(chǎng)進(jìn)行模擬分析。FDTD計(jì)算表明在島狀納米結(jié)構(gòu)的“狹縫”處的電場(chǎng)強(qiáng)度最高,理論增強(qiáng)因子可達(dá)105。微引擎的SERS性能可以通過改變Au層的厚度或包覆增益介質(zhì)來調(diào)控。3.通過改變過氧化氫濃度等參數(shù),我們研究了催化微引擎的運(yùn)動(dòng)軌跡、運(yùn)動(dòng)速度和富集特性等行為�；诖呋⒁娴奈⑾到y(tǒng)中測(cè)得的羅丹明6G分子的SERS信號(hào)是傳統(tǒng)方法的約5倍,表現(xiàn)出微引擎系統(tǒng)的優(yōu)越性。游動(dòng)的催化微引擎作為化學(xué)生物分子的有效載體,擴(kuò)展了收集分子的路徑并增加了吸附分子的概率。此外,微系統(tǒng)中的微引擎可自主運(yùn)動(dòng)至收集、檢測(cè)區(qū)域,相比傳統(tǒng)的SERS檢測(cè)方法屬于非接觸式檢測(cè),擴(kuò)展了檢測(cè)領(lǐng)域,具有光明的應(yīng)用前景。
[Abstract]:Manipulating and detecting molecules on microchips is aimed at making molecular detection easier, cheaper and more stable. Researchers in the fields of biological analysis, optical flow control and so on have attached great importance to the manipulation and detection of molecules. Surface enhanced Raman scattering spectroscopy (SERS) is a powerful and sensitive analytical tool for detecting and identifying trace molecules by using the SERS effect to collect the "fingerprint spectra" of the detected molecules. Using SERS spectroscopy to detect chemical and biological monolayers, the developing trend is to modify the substrate and integrate with other platforms to realize a multi-functional and practical integrated detection system. In this work, multilayer micron tubes were fabricated by curling nanotechnology, and their geometrical structures were combined with surface modification to make them have SERS properties. In addition, the micron tubular structure can be used as a microengine and an effective carrier for the transport of molecules, which can be used for the collection and detection of chemical and biological molecules in fluid, which provides a great potential for its application in the field of biological analysis. The main work and results are as follows: 1. Au/SiO/Ti/Ag catalytic microengines were prepared by curling nanotechnology. The multilayer materials were selected to meet the multifunctional requirements. The shape of nanocrystalline films is designed by means of UV lithography or metal mask plate, and the directional curling of nanocrystalline films is realized by introducing etching agent in a specific position, so that different shapes of microengines can be obtained. By changing the thickness of the nanocrystalline film, the stress gradient of the film can be affected and the diameter of the Au/SiO/Ti/Ag microengine tube can be adjusted. In addition, by changing the substrate surface structure of the deposited nanocrystalline films, a nanostructured micro engine. 2. 2 can be prepared. Due to the excellent SERS activity of au and the rough nanostructures on the surface of the micro engine, the micro engine exhibits excellent SERS properties. The finite difference time-domain (FDTD) method is used to model the surface electromagnetic field of catalytic microengine. The FDTD calculation shows that the electric field intensity is the highest at the "slit" of the island nanostructure, and the theoretical enhancement factor can reach 105. The SERS performance of the microengine can be adjusted by changing the thickness of the au layer or coating the gain medium. By changing the concentration of hydrogen peroxide, we studied the motion trajectory, velocity and enrichment characteristics of the catalytic microengine. The SERS signal of Rhodamine 6G molecule measured in the catalytic microengine based microsystem is about 5 times that of the traditional method, which shows the superiority of the micro engine system. As an effective carrier of chemical and biological molecules, the mobile catalytic microengine extends the path of collecting molecules and increases the probability of adsorbing molecules. In addition, the micro engine in the micro system can move to the collection and detection area independently. Compared with the traditional SERS detection method, it belongs to the non-contact detection, which expands the detection field and has a bright application prospect.
【學(xué)位授予單位】：東南大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2017
【分類號(hào)】：O652

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