本文選題：二甲雙胍 + 環(huán)化反應(yīng)機(jī)理　； 參考：《安徽工業(yè)大學(xué)》2017年碩士論文

【摘要】：二甲雙胍是胍類化合物之中十分重要的降血糖藥物之一,而由其合成1,3,5-三嗪類衍生物屬于用途特別廣泛的含氮有機(jī)化合物,在醫(yī)藥、農(nóng)藥等領(lǐng)域中的地位非常關(guān)鍵,一直以來也是科研界所研究的熱點(diǎn)。通過采用對二甲雙胍的結(jié)構(gòu)進(jìn)行適當(dāng)?shù)难苌揎椀确椒?很可能會獲得對細(xì)菌的抑制活性很好、并且抑菌譜廣等優(yōu)點(diǎn)的1,3,5-三嗪類衍生物,從而能夠更好地應(yīng)用到醫(yī)學(xué)、藥學(xué)、化工行業(yè)等領(lǐng)域。因此,本論文的研究主要包括以下三個(gè)部分:(1)利用鹽酸二甲胺和雙氰胺為原料來設(shè)計(jì)合成出鹽酸二甲雙胍,并進(jìn)一步對設(shè)計(jì)方案從溶劑的選擇,反應(yīng)物配比的比較,反應(yīng)溫度對產(chǎn)物產(chǎn)率的影響,反應(yīng)時(shí)間對產(chǎn)物產(chǎn)率的影響,實(shí)驗(yàn)處理工藝的優(yōu)化等方面進(jìn)行了比較系統(tǒng)的研究,最終確定了一種簡單易行,綠色環(huán)保,特別是產(chǎn)品中二甲胺殘留量可以控制在10ppm以下,適合進(jìn)行工藝化生產(chǎn)的最優(yōu)方案。(2)詳細(xì)介紹了利用原料二甲雙胍來制備1,3,5-三嗪類衍生物的合成方法,以及新制備的1,3,5-三嗪類衍生物在農(nóng)藥行業(yè)(除草劑)、紫外線吸收劑、醫(yī)藥行業(yè),和光學(xué)領(lǐng)域中的用途等方面的重要的應(yīng)用。合成了22個(gè)1,3,5-三嗪類衍生物,并對這三類衍生物的反應(yīng)機(jī)理進(jìn)行了詳細(xì)的研究,采用核磁共振氫譜、紅外光譜、紫外—可見吸收光譜等譜學(xué)表征。(3)通過對二甲雙胍與部分過渡金屬的配位進(jìn)行分析,對可能的反應(yīng)機(jī)理進(jìn)行了相關(guān)的理論計(jì)算。探索了10個(gè)由二甲雙胍衍生物與金屬離子的配位反應(yīng),以及可能形成的金屬配合物的基本譜學(xué)表征,探究了不同的配位金屬對紫外-可見吸收光譜的吸收峰的影響。
[Abstract]:Metformin is one of the most important hypoglycemic drugs in guanidine compounds. It has always been a hot spot in the scientific research field. By means of proper derivatization and modification of metformin structure, it is very likely that the antibacterial activity of metformin will be very good, and that the derivatives of 1-triazine with wide antibacterial spectrum will be better applied to medicine and pharmacy. Chemical industry and other fields. Therefore, the research in this paper mainly includes the following three parts: 1) the metformin hydrochloride is designed and synthesized by using dimethylamine hydrochloride and dicyandiamide as raw materials, and the design scheme is further compared from the selection of solvent and the proportion of reactants. The effect of reaction temperature on the yield of the product, the effect of reaction time on the yield of the product, and the optimization of the experimental treatment process were studied systematically. In particular, the dimethylamine residue in the product can be controlled below 10ppm, and the optimum scheme for the production of dimethylamine, which is suitable for the process production, is described in detail. The synthetic method for the preparation of 1ttriazine derivatives by using metformin as raw material is introduced in detail. As well as the important applications of the newly prepared triazine derivatives in the pesticide industry (herbicide, ultraviolet absorbent, pharmaceutical industry, optical field, etc.) In this paper, 22 1-triazine derivatives have been synthesized, and their reaction mechanism has been studied in detail. Nuclear magnetic resonance spectroscopy (NMR) and infrared spectroscopy (IR) have been used to study the reaction mechanism of these three derivatives. By analyzing the coordination of metformin with some transition metals, the possible reaction mechanism was calculated theoretically. The coordination reactions of metformin derivatives with metal ions and the basic spectral characterization of metal complexes were investigated. The effects of different coordination metals on the absorption peaks of UV-Vis absorption spectra were investigated.
【學(xué)位授予單位】：安徽工業(yè)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：O626

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本文編號：1880366