本文選題：水凝膠 + 纖維素��； 參考：《南京大學(xué)》2017年碩士論文

【摘要】：水凝膠是一種特殊的"軟"材料,它具有溶脹率高、機(jī)械強(qiáng)度大、生物相容性好和生物可降解等優(yōu)點(diǎn),在工業(yè)、農(nóng)業(yè)、生物醫(yī)學(xué)等領(lǐng)域均有廣泛的應(yīng)用。纖維素及其衍生物,因其來(lái)源豐富、可用性強(qiáng)等優(yōu)點(diǎn),常常被用來(lái)制備水凝膠。但傳統(tǒng)方法制備的水凝膠存在一些缺點(diǎn):機(jī)械性能差,溶脹率低等。本論文首先選取羥乙基纖維素(HEC),合成了半互穿網(wǎng)絡(luò)結(jié)構(gòu)的水凝膠,證實(shí)了其具有良好的機(jī)械性能。而后選取了羥丙基纖維素(HPC),合成了一種可注射水凝膠,證實(shí)了其具有生物相容性和生物可降解性。具體內(nèi)容如下:1、首先我們針對(duì)傳統(tǒng)水凝膠機(jī)械強(qiáng)度弱的問(wèn)題,選用丙烯酸(AA)、木質(zhì)素磺酸鹽、羥乙基纖維素(HEC),通過(guò)原位聚合方法合成了一種半互穿網(wǎng)絡(luò)結(jié)構(gòu)的水凝膠(LS-A/H),并對(duì)水凝膠的機(jī)械性能、表面形貌、溶脹率等進(jìn)行了研究。結(jié)果表明LS-A/H水凝膠是一種三維多孔網(wǎng)狀結(jié)構(gòu)高分子聚合物,內(nèi)孔大小均一。LS-A/H水凝膠在不同pH環(huán)境下和不同的鹽溶液中溶脹率有較大差異,可將其用來(lái)吸附有機(jī)染料或者重金屬離子。同時(shí)LS-A/H水凝膠呈現(xiàn)了較好的機(jī)械性能,有望應(yīng)用于組織工程領(lǐng)域。這種半互穿網(wǎng)絡(luò)結(jié)構(gòu)的水凝膠可操作性強(qiáng),有較好的發(fā)展前景。同時(shí)也為木質(zhì)素磺酸鹽的使用找尋了新的方向,達(dá)到了我們?cè)O(shè)計(jì)的初衷。2、針對(duì)化學(xué)方法制備水凝膠存在部分毒性這一問(wèn)題,我們選用羥丙基纖維素(HPC)、松香酸(AA)和牛血清蛋白(BSA)作為原料,合成了一種可注射型水凝膠(HPC-AA/BSA)。這種可注射型水凝膠初始狀態(tài)為溶液,當(dāng)調(diào)節(jié)環(huán)境的pH和溫度,溶液內(nèi)分子會(huì)以氫鍵方式結(jié)合形成三維網(wǎng)絡(luò)交聯(lián)結(jié)構(gòu)。通過(guò)對(duì)水凝膠形成時(shí)間的測(cè)定,可得快速成凝膠的實(shí)驗(yàn)條件。通過(guò)對(duì)水凝膠形貌、流變性能、藥物釋放、細(xì)胞毒性等研究,發(fā)現(xiàn)此水凝膠具有安全性高、生物相容性好和生物可降解性好等特點(diǎn)。通過(guò)對(duì)水凝膠失水率測(cè)定,發(fā)現(xiàn)此水凝膠具有良好的保濕性能,可應(yīng)用于面膜、眼膜等化妝品行業(yè)。本設(shè)計(jì)方案為合成可注射水凝膠提供了一個(gè)新思路,同時(shí)也拓展了可注射水凝膠在臨床方面的應(yīng)用。
[Abstract]:Hydrogel is a special "soft" material. It has many advantages such as high swelling rate, high mechanical strength, good biocompatibility and biodegradability. It is widely used in industry, agriculture, biomedicine and so on. Cellulose and its derivatives are often used to prepare hydrogels because of their rich sources and high availability. However, the hydrogels prepared by traditional methods have some disadvantages, such as poor mechanical properties, low swelling rate and so on. In this paper, hydrogels with semi-interpenetrating network structure were synthesized by HEC-hydroxyethyl cellulose (HEC) and proved to have good mechanical properties. Then, an injectable hydrogel was synthesized from HPC-HPC, which proved its biocompatibility and biodegradability. The specific contents are as follows: 1. First of all, in view of the problem of weak mechanical strength of traditional hydrogels, we select acrylic acid (AA), lignosulfonate (lignosulfonate), Hydroxyethyl cellulose (HEC) was synthesized by in-situ polymerization. The mechanical properties, surface morphology and swelling rate of the hydrogel were studied. The results show that LS-A/H hydrogel is a kind of three-dimensional porous polymer with network structure. The swelling rate of LS-A / H hydrogel with uniform inner pore size in different pH conditions and different salt solutions is different. It can be used to adsorb organic dyes or heavy metal ions. At the same time, LS-A/H hydrogels exhibit good mechanical properties, which are expected to be used in tissue engineering. The hydrogel with semi-interpenetrating network structure has strong maneuverability and good development prospect. It also provides a new direction for the use of lignosulfonate and achieves the original intention of our design. 2. In view of the problem of partial toxicity of hydrogels prepared by chemical methods, An injectable hydrogel (HPC-AA / BSAA) was synthesized by using hydroxypropyl cellulose (HPC), rosin acid (AAA) and bovine serum protein (BSA) as raw materials. The initial state of the injectable hydrogel is a solution. When the pH and temperature of the solution are adjusted, the molecules in the solution will combine in a hydrogen bond manner to form a three-dimensional network crosslinking structure. By measuring the formation time of hydrogels, the experimental conditions for rapid formation of hydrogels can be obtained. By studying the morphology, rheological properties, drug release and cytotoxicity of the hydrogel, it was found that the hydrogel had the characteristics of high safety, good biocompatibility and biodegradability. By measuring the water loss rate of hydrogel, it is found that the hydrogel has good moisturizing property and can be used in cosmetic industry such as facial mask and eye film. The design provides a new idea for the synthesis of injectable hydrogels and extends the clinical application of injectable hydrogels.
【學(xué)位授予單位】：南京大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：O648.17
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本文編號(hào)：1845357