本文選題：C-H鍵活化 + 雙亞砜��； 參考：《合肥工業(yè)大學(xué)》2017年碩士論文

【摘要】：近年來,過渡金屬催化C-H鍵活化直接構(gòu)建C-N鍵偶聯(lián)反應(yīng)的研究發(fā)展很快,如烯基、芳基、烯丙基以及烷基的C-N鍵反應(yīng),其在全合成和藥物合成中也有廣泛的應(yīng)用。C-H鍵活化反應(yīng)中的基質(zhì)和均相催化的條件對配體的要求較高。因此本文首先設(shè)計(jì)合成了 12種結(jié)構(gòu)新穎的雙亞砜配體,并從中篩選出了一種催化效果最好的金剛烷基雙亞砜配體。使用該雙亞砜配體與醋酸鈀絡(luò)合催化烯丙基C-H鍵胺化反應(yīng)時(shí),可以在較低的催化劑負(fù)載下(2 mmol%)進(jìn)行反應(yīng),添加劑的使用量也在一定程度上有所減少。并且這種配體提高了 C-N鍵偶聯(lián)的底物適用范圍和產(chǎn)率,C-N鍵的偶聯(lián)產(chǎn)物也可以在酸性或者堿性條件下脫保護(hù)。
[Abstract]:In recent years, the transition metal catalyzed C-H bond activation has been developed rapidly, such as the C-N bond reactions of allyl, aryl, allyl and alkyl. It is also widely used in the synthesis of total and pharmaceutical compounds. The conditions of matrix and homogeneous catalysis in the activation of .C-H bond require higher ligands. In this paper, 12 novel bissulfoxide ligands were designed and synthesized, and one of the best catalytic ligands was selected. The reaction of allyl C-H bond amination with palladium acetate was catalyzed by the ligand of disulfoxide, and the amount of additive was reduced to a certain extent. Moreover, the ligand enhanced the suitable range of substrate and yield of C-N bond and the coupling product of C-N bond could also be deprotected under acidic or alkaline conditions.
【學(xué)位授予單位】：合肥工業(yè)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：O621.251

【參考文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 何剛;雙亞砜—鈀催化烯丙基C-H鍵直接官能化[D];合肥工業(yè)大學(xué);2016年

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本文編號：1808215