本文選題：金屬配位化學(xué) + 殼聚糖�。� 參考：《東南大學(xué)》2017年碩士論文

【摘要】：水凝膠是由聚合物交聯(lián)而成的具有三維空間網(wǎng)絡(luò)結(jié)構(gòu)的材料。殼聚糖及其衍生物因價(jià)格低廉易得、易降解及生物相容性好等優(yōu)點(diǎn),被廣泛的應(yīng)用到水凝膠材料的研究中。將水凝膠干燥得到復(fù)合膜材料,與傳統(tǒng)方法制備的復(fù)合膜相比,殼聚糖衍生物復(fù)合膜的機(jī)械強(qiáng)度和物理化學(xué)性質(zhì)更優(yōu)良,且具有良好的抗菌效果,在生物材料領(lǐng)域有潛在的實(shí)際應(yīng)用價(jià)值。金屬配位化學(xué)是物理法制備水凝膠的方法之一,具有高效性、反應(yīng)周期短、較好的官能團(tuán)容忍度等優(yōu)點(diǎn)。與傳統(tǒng)物理方法制備水凝膠相比,金屬離子交聯(lián)配位克服了交聯(lián)網(wǎng)絡(luò)結(jié)構(gòu)不規(guī)整、穩(wěn)定性差和缺陷多的缺點(diǎn)。本文利用�；磻�(yīng)制備了一系列具有不同取代度的丁二酸酐�；瘹ぞ厶�(NSCS),通過(guò)~1HNMR、FT-IR、XRD和元素分析對(duì)合成的化合物結(jié)構(gòu)進(jìn)行確認(rèn),證明其成功合成;通過(guò)金屬離子與丁二酸酐�；瘹ぞ厶�(NSCS)交聯(lián)配位,及金屬離子與丁二酸酐酰化殼聚糖(NSCS)-氧化石墨烯(GO)交聯(lián)配位制備了一系列具有規(guī)整結(jié)構(gòu)的水凝膠,再將所制備的水凝膠干燥后得到輕質(zhì)、物理化學(xué)性能優(yōu)良的復(fù)合膜,這是一種操作簡(jiǎn)便易行、綠色經(jīng)濟(jì)且全新的制備納米復(fù)合膜的方法。利用SEM、XPS、TGA、溶脹率、穩(wěn)定性、機(jī)械強(qiáng)度、抗菌性測(cè)試等對(duì)復(fù)合膜性能進(jìn)行表征。其中本課題以鋅離子配位制得的復(fù)合膜性能更加優(yōu)良,當(dāng)NSCS取代度為91.80%時(shí),NSCS-Zn(Ⅱ)拉伸強(qiáng)度和楊氏模量達(dá)到119.3 MPa和2.67 GPa,NSCS-GO-Zn(Ⅱ)復(fù)合膜表現(xiàn)出優(yōu)秀的機(jī)械性能,拉伸強(qiáng)度達(dá)到212.6±10.1 MPa,韌性為2.51 ±0.08 MJ/m3。高強(qiáng)度復(fù)合膜不僅有高的機(jī)械強(qiáng)度還具有良好的殺菌效果,其優(yōu)異性能在醫(yī)學(xué)材料領(lǐng)域有潛在的實(shí)際應(yīng)用價(jià)值。
[Abstract]:Hydrogel is a material with three-dimensional network structure which is crosslinked by polymer. Chitosan and its derivatives have been widely used in hydrogel materials because of their advantages of low cost, easy degradation and good biocompatibility. The composite membrane material was prepared by drying the hydrogel. Compared with the traditional composite membrane, the chitosan derivative composite membrane has better mechanical strength and physical and chemical properties, and has a good antibacterial effect. It has potential application value in the field of biomaterials. Metal coordination chemistry is one of the physical methods for the preparation of hydrogels, which has the advantages of high efficiency, short reaction period and good tolerance of functional groups. Compared with the traditional physical method, metal ion crosslinking coordination overcomes the shortcomings of irregular crosslinking network structure, poor stability and many defects. In this paper, a series of succinic anhydride acylated chitosan (NSCS) with different degree of substitution were prepared by acylation reaction. The structure of the synthesized compounds was confirmed by XRD and elemental analysis. A series of hydrogels with regular structure were prepared by the crosslinking coordination of metal ions with succinic anhydride acylated chitosan (NSCS) and metal ions with succinic anhydride acylated chitosan (NSCS) -graphene oxide (GOO). After drying the prepared hydrogels, the composite membranes with light weight and excellent physical and chemical properties were obtained, which is a simple, convenient, green and new method for preparing nanocomposite membranes. The properties of the composite membrane were characterized by SEMX PSN TGA, swelling rate, stability, mechanical strength and antibacterial test. The composite film prepared by zinc ion coordination in this paper has better properties. When the degree of substitution of NSCS is 91.80, the tensile strength and Young's modulus of NSCS-Zn (鈪，

本文編號(hào)：1787215