本文選題：活性羰基化合物　切入點(diǎn)：熒光探針　出處：《有機(jī)化學(xué)》2017年08期

【摘要】：活性羰基化合物一直以來被人們稱為致癌物和人類毒物,當(dāng)其濃度升高時(shí),會(huì)導(dǎo)致多種疾病,因此,設(shè)計(jì)開發(fā)用于選擇性識(shí)別和高靈敏檢測生物體內(nèi)的活性羰基化合物的技術(shù)具有十分重要的意義.近年來,熒光探針具有操作簡單、靈敏度高、選擇性好,響應(yīng)時(shí)間短以及能實(shí)現(xiàn)實(shí)時(shí)檢測等優(yōu)勢,在活性羰基化合物及其他活性物種如活性氧、活性氮、次氯酸以及硫醇等物質(zhì)的檢測方面獲得了快速發(fā)展.鑒于活性羰基化合物熒光探針綜述方面的報(bào)道很少,從探針分子與待測物之間發(fā)生的反應(yīng)類別進(jìn)行歸納和總結(jié),概括了甲醛、甲基乙二醛、丙二醛以及丙烯醛等活性羰基化合物的熒光探針,并從設(shè)計(jì)理念、識(shí)別機(jī)理以及應(yīng)用等方面進(jìn)行了描述,還對(duì)活性羰基化合物熒光探針的設(shè)計(jì)和應(yīng)用前景提出了展望.
[Abstract]:Active carbonyl compounds have long been known as carcinogens and human poisons. When their concentrations increase, they can lead to many diseases, so, It is of great significance to design and develop a technique for selective recognition and highly sensitive detection of active carbonyl compounds in organisms. In recent years, fluorescent probes have been characterized by simple operation, high sensitivity and good selectivity. Short response time and the ability to achieve real-time detection of such advantages as active carbonyl compounds and other active species such as reactive oxygen, active nitrogen, Rapid progress has been made in the detection of hypochloric acid and mercaptan. In view of the few reports on fluorescent probes for active carbonyl compounds, the types of reactions between the probe molecules and the substances to be tested are summarized and summarized. The fluorescent probes of active carbonyl compounds such as formaldehyde, methyl Glyoxal, malondialdehyde and acrolein were summarized, and the design idea, recognition mechanism and application were described. The prospect of the design and application of fluorescent probes for active carbonyl compounds is also presented.
【作者單位】： 武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院;
【基金】：國家自然科學(xué)基金(No.21401144) 湖北省自然科學(xué)基金(No.2013CFB236)資助項(xiàng)目~~
【分類號(hào)】：O657.3

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