本文選題：液相色譜-質(zhì)譜聯(lián)用儀　切入點(diǎn)：接口技術(shù)　出處：《分析測(cè)試學(xué)報(bào)》2017年12期 　論文類型：期刊論文

【摘要】：自制了一套液相色譜-質(zhì)譜聯(lián)用接口,接口包含大氣壓接口、離子源及連接高效液相色譜進(jìn)樣器和質(zhì)譜采集軟件的電子通訊接口。成功地將賽默飛世爾高效液相色譜戴安U3000與團(tuán)隊(duì)自主研制的APITOFMS10000相連。實(shí)驗(yàn)結(jié)果表明,自行搭建的液質(zhì)聯(lián)用儀有很好的穩(wěn)定性(RSD=5.6%),線性相關(guān)系數(shù)(r2)為0.995 8,線性范圍為2~2 000 pg,定量下限為2 pg,檢出限為0.5 pg�？擅黠@檢出吡羅昔康、茶堿和潑尼松3種標(biāo)準(zhǔn)藥品。實(shí)驗(yàn)數(shù)據(jù)表明自行研發(fā)的液相色譜-質(zhì)譜聯(lián)用接口滿足應(yīng)用要求,搭建的液相色譜-質(zhì)譜聯(lián)用儀在生物化學(xué)、醫(yī)藥分析、食品安全、環(huán)境檢測(cè)等領(lǐng)域具有應(yīng)用潛力。
[Abstract]:A set of liquid chromatography-mass spectrometry (LC-MS) interface is developed. The interface includes atmospheric pressure interface. The ion source and the electronic communication interface connecting the high performance liquid chromatography injector and the mass spectrometry acquisition software have been successfully linked to the APITOFMS10000 developed by the team. The self-built liquid-mass spectrometer has a good stability. The linear correlation coefficient is 0.995 8, the linear range is 2 000 PG, the lower limit of quantification is 2 PG, the detection limit is 0.5 PG, and the Piroxicam can be detected obviously, the linear correlation coefficient is 0.995 8, the linear range is 2 000 PG, the detection limit is 0.5 PG, the linear correlation coefficient is 0.995 8, the limit of detection is 2 PG, and the detection limit is 0.5 PG. Theophylline and prednisone are three kinds of standard drugs. The experimental data show that the self-developed liquid chromatography-mass spectrometry (LC-MS) interface meets the requirements of application. The constructed LC-MS instrument is used in biochemistry, medical analysis, food safety, Environmental detection and other fields have application potential.
【作者單位】： 暨南大學(xué)質(zhì)譜儀器與大氣環(huán)境研究所;昆山禾信質(zhì)譜技術(shù)有限公司;廣東省大氣污染在線源解析系統(tǒng)工程技術(shù)研究中心;廣州禾信儀器股份有限公司;
【基金】：廣州市產(chǎn)學(xué)研項(xiàng)目(201604010065);廣州市產(chǎn)學(xué)研項(xiàng)目(201604040007) 廣州珠江新星項(xiàng)目(201710010005)資助
【分類號(hào)】：O657.63

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