本文關(guān)鍵詞： 近紅外光譜 輔料 支持向量機(jī)回歸分析 隨機(jī)青蛙法 苯磺酸氨氯地平片　出處：《光子學(xué)報(bào)》2017年01期 　論文類型：期刊論文

【摘要】：將近紅外光譜技術(shù)和化學(xué)計(jì)量學(xué)相結(jié)合快速檢測苯磺酸氨氯地平片輔料含量.通過隨機(jī)青蛙法、變量投影重要性和競爭自適應(yīng)重加權(quán)采樣篩選特征波長變量點(diǎn),采用9種光譜預(yù)處理方法對原始光譜進(jìn)行處理后,分別建立了偏最小二乘法模型和支持向量回歸分析模型,并將這兩種模型進(jìn)行了比較.應(yīng)用優(yōu)選模型對樣品進(jìn)行了測試,結(jié)果表明:對于所涉及的樣本,在最優(yōu)特征波長變量選擇上,隨機(jī)青蛙法效果較好;在模型預(yù)測結(jié)果上,與支持向量回歸分析模型相比,5個(gè)指標(biāo)的偏最小二乘法定量模型的決定系數(shù),預(yù)測均方根誤差評價(jià)參數(shù)效果較好,相對分析誤差值均大于3.0.樣品測試值與實(shí)測值標(biāo)準(zhǔn)誤差均小于1.30,配對t檢驗(yàn)表明,在a=0.05顯著性水平上,兩者無顯著性差異.因此,可采用近紅外漫反射光譜法用于苯磺酸氨氯地平片輔料含量的快速檢測,該方法重復(fù)性、中間精密度、線性、精確性良好,且可為其他藥用輔料含量快速檢測提供借鑒.
[Abstract]:Rapid detection of amlodipine benzenesulfonate excipient content by means of near infrared spectroscopy and chemometrics. By means of random frog method, variable projection importance and competitive adaptive re-weighted sampling were used to screen characteristic wavelength variable points. After processing the original spectrum with 9 spectral pretreatment methods, the partial least square model and the support vector regression model were established, and the two models were compared. The results show that for the samples involved, the random frog method is effective in selecting the optimal characteristic wavelength variables, and in the prediction results of the model, Compared with the support vector regression model, the determination coefficient of the partial least square quantitative model of five indexes is better than that of the support vector regression model, and the evaluation parameters of root-mean-square error prediction are better than that of the support vector regression model. The error of relative analysis is all greater than 3.0.The standard error of sample test value and actual value is less than 1.30. The paired t test shows that there is no significant difference between the two at the significant level of aaqian 0.05, so, there is no significant difference between them. The near infrared diffuse reflectance spectroscopy can be used to detect the excipient content of amlodipine benzenesulfonate tablets quickly. The method has the advantages of repeatability, intermediate precision, linearity, good accuracy, and can be used as a reference for the rapid determination of other medicinal excipients.
【作者單位】： 佳木斯大學(xué)藥學(xué)院;大連達(dá)碩信息技術(shù)有限公司;
【基金】：The Postgraduate Student Scientific Innovation Project in Jiamusi University(No.LM2015_082)
【分類號】：R927.2;O657.3

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