本文關鍵詞： 葉綠素 二氫卟吩 牛血清白蛋白 化學修飾 熒光淬滅　出處：《有機化學》2017年07期 　論文類型：期刊論文

【摘要】：以脫鎂葉綠酸-a(b)甲酯為起始原料,經外接環(huán)修飾和色基金屬化形成不同的葉綠素降解產物,再通過Vilsmeier�；虰lanc羥甲基化反應,在20-位上引進了新的官能基團.以四氧化鋨、硝酸鉈和空氣為氧化劑,對二氫卟吩周環(huán)上的活性結構進行氧化,分別在二氫卟吩周環(huán)上的3-,7-和12-位以及外接環(huán)上引進了甲�；图柞＜谆�,合成了一系列未見報道的葉綠素類二氫卟吩醛衍生物,其化學結構均經UV,IR,~1H NMR及元素分析予以證實;同時也討論了葉綠素類二氫卟吩醛基化的反應機理,并對新化合物與牛血清白蛋白的結合作用進行了研究.
[Abstract]:A new functional group was introduced at the 20- site from the starting material of methyl demagnesium chlorophorate, which was modified with outer ring and metallized by chromatic group to form different products of chlorophyll degradation, and then through Vilsmeier acylation and Blanc hydroxylation, a new functional group was introduced at the 20- site, and osmium tetroxide was used as the starting material. The active structure of chlorin ring was oxidized by thallium nitrate and air. Formyl groups and formylmethyl groups were introduced at the 3-and 12-sites and on the outer ring of porphin ring, respectively. A series of unreported derivatives of chlorophyll chlorin aldehyde were synthesized and their chemical structures were confirmed by NMR and elemental analysis, and the reaction mechanism of chlorin aldehyde reaction was also discussed. The binding of new compounds to bovine serum albumin (BSA) was studied.
【作者單位】： 煙臺大學文經學院食品與生物工程系;煙臺大學化學化工學院;
【基金】：國家自然科學基金(No.21272048) 山東省高校科技計劃(No.J15LC51)資助項目~~
【分類號】：O626
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本文編號：1501297