本文關(guān)鍵詞： 葉綠素 二氫卟吩 牛血清白蛋白 化學(xué)修飾 熒光淬滅　出處：《有機(jī)化學(xué)》2017年07期 　論文類型：期刊論文

【摘要】：以脫鎂葉綠酸-a(b)甲酯為起始原料,經(jīng)外接環(huán)修飾和色基金屬化形成不同的葉綠素降解產(chǎn)物,再通過Vilsmeier�；虰lanc羥甲基化反應(yīng),在20-位上引進(jìn)了新的官能基團(tuán).以四氧化鋨、硝酸鉈和空氣為氧化劑,對(duì)二氫卟吩周環(huán)上的活性結(jié)構(gòu)進(jìn)行氧化,分別在二氫卟吩周環(huán)上的3-,7-和12-位以及外接環(huán)上引進(jìn)了甲�；图柞＜谆�,合成了一系列未見報(bào)道的葉綠素類二氫卟吩醛衍生物,其化學(xué)結(jié)構(gòu)均經(jīng)UV,IR,~1H NMR及元素分析予以證實(shí);同時(shí)也討論了葉綠素類二氫卟吩醛基化的反應(yīng)機(jī)理,并對(duì)新化合物與牛血清白蛋白的結(jié)合作用進(jìn)行了研究.
[Abstract]:A new functional group was introduced at the 20- site from the starting material of methyl demagnesium chlorophorate, which was modified with outer ring and metallized by chromatic group to form different products of chlorophyll degradation, and then through Vilsmeier acylation and Blanc hydroxylation, a new functional group was introduced at the 20- site, and osmium tetroxide was used as the starting material. The active structure of chlorin ring was oxidized by thallium nitrate and air. Formyl groups and formylmethyl groups were introduced at the 3-and 12-sites and on the outer ring of porphin ring, respectively. A series of unreported derivatives of chlorophyll chlorin aldehyde were synthesized and their chemical structures were confirmed by NMR and elemental analysis, and the reaction mechanism of chlorin aldehyde reaction was also discussed. The binding of new compounds to bovine serum albumin (BSA) was studied.
【作者單位】： 煙臺(tái)大學(xué)文經(jīng)學(xué)院食品與生物工程系;煙臺(tái)大學(xué)化學(xué)化工學(xué)院;
【基金】：國(guó)家自然科學(xué)基金(No.21272048) 山東省高校科技計(jì)劃(No.J15LC51)資助項(xiàng)目~~
【分類號(hào)】：O626
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本文編號(hào)：1501297