發(fā)布時間：2018-06-22 03:52

  本文選題：藥物及個人護理品 + 液相色譜-串聯質譜��； 參考：《湖南師范大學》2015年碩士論文

【摘要】：PPCPs是藥物及個人護理品(pharmaceutical and personal care products)的英文簡稱,包括各種處方藥、非處方藥以及個人皮膚護理等。部分PPCPs組分具有較強的生物活性、旋光性、生物富集性及生物毒性。近年來,國內外針對地表水、飲用水以及河流沉積物中的PPCPs研究較多,但是有關對垃圾填埋場滲濾液、污水處理廠、納污河流等典型污染源以及地下水中PPCPs的濃度分布水平的研究較少。珠三角地區(qū)是我國經濟實力和創(chuàng)新能力最強的三大區(qū)域之一,藥物與個人護理品的用量大,因此開展珠三角地區(qū)典型污染源與地下水中PPCPs的濃度水平及分布研究,對于評估珠三角地區(qū)PPCPs類物質的污染水平具有重要的意義。本研究建立了PPCPs的分析方法,并以此方法分析珠三角地區(qū)垃圾填埋場滲濾液、污水處理廠、納污河流等典型污染源以及地下水中PPCPs的濃度水平及分布,探討了珠三角地區(qū)典型污染源及地下水中PPCPs分布特征,得到主要的結論如下：1)通過對液相色譜、質譜及固相萃取條件的優(yōu)化,建立了可快速、準確測定水環(huán)境中3種PPCPs的HPLC-MS/MS的檢測及其前處理方法,研究確定了15種PPCPs類物質的方法檢測限、線性方程、相關系數、加標回收率和相對標準偏差等指標,并將已建立的分析方法成功應用于實際樣品的檢測。2、對垃圾滲濾液、污水處理廠、納污河流中地下水中15種PPCPs的分布特征研究表明：兩座垃圾填埋場各采樣點中藥物種類較少、濃度較低；SPT-A、SPT-B和SPT-C各工藝單元出水中15種PPCPs總檢出濃度范圍在470-2739.4ng/L之間,其中CF和KP為主要檢出目標物質；結果還表明,該污水處理工藝不能很好的去除15種PPCPs;廣州市2處典型污染河涌中PPCPs的總濃度介于135.84-606.62ng/L,主要污染物為CF和SP,其污染程度的嚴重程度與河涌的直接排放污染源有關。3、分析珠三角地區(qū)各地方地下水數據,可知珠三角地區(qū)地下水采樣點中ΣPPCPs介于ND～33.53ng/L之間,單個目標物質的總檢出濃度范圍是0.24～52.84ng/L,主要污染物為CF和IM；在調查的城中村及郊區(qū)地下水中,受PPCPs污染程度依次是廣州佛山清遠東莞且地下水中PPCPs受皮革廠的污染較電子加工廠更為嚴重。本研究為我國相關部門及國內外研究者研究珠三角地區(qū)典型污染源及地下水中PPCPs的濃度水平、污染現狀、風險評價、源解析及防控提供科學依據。
[Abstract]:PPCPs is the abbreviation of (pharmaceutical and personal care products) for drugs and personal care products, including all kinds of prescription drugs, over-the-counter drugs and personal skin care. Some PPCPs have strong bioactivity, optical activity, bioconcentration and toxicity. In recent years, there have been many studies on PPCPs in surface water, drinking water and river sediments at home and abroad. There are few studies on concentration distribution of PPCPs in groundwater and typical pollution sources such as sewage rivers. The Pearl River Delta region is one of the three regions with the strongest economic strength and innovation ability in China, and the dosage of drugs and personal care products is large. Therefore, the concentration and distribution of PPCPs in typical pollution sources and groundwater in the Pearl River Delta region are studied. It is of great significance to assess the pollution level of PPCPs in the Pearl River Delta region. In this study, the analysis method of PPCPs was established, and the concentration and distribution of PPCPs in landfill leachate, sewage treatment plant, sewage treatment river and groundwater in the Pearl River Delta region were analyzed. The distribution characteristics of PPCPs in typical pollution sources and groundwater in the Pearl River Delta region are discussed. The main conclusions are as follows: 1) by optimizing the conditions of liquid chromatography, mass spectrometry and solid phase extraction, it is found that PPCPs can be quickly obtained. The HPLC-MS / MS detection and pretreatment methods of three PPCPs in water environment were accurately determined. The detection limits, linear equations, correlation coefficients, recoveries and relative standard deviations of 15 PPCPs were determined. The established analytical method has been successfully applied to the detection of actual samples. The distribution characteristics of 15 kinds of PPCPs in leachate, sewage treatment plant and groundwater in sewage treatment plants are studied. The results show that there are fewer kinds of drugs in each sampling site of two landfills. The total detectable concentrations of 15 PPCPs in the effluent of each process unit were 470-2739.4 ng / L, in which CF and KP were the main target substances. The total concentration of PPCPs in two typical polluted rivers in Guangzhou is between 135.84-606.62ng / L, and the main pollutants are CF and SP.The severity of the pollution is related to the direct discharge pollution source of the river, and the total concentration of PPCPs in the two typical polluted rivers in Guangzhou is between 135.84-606.62ng/ L, and the main pollutants are CF and SP.The degree of pollution is related to the direct discharge pollution source of the river. Analysis of local groundwater data in the Pearl River Delta region, It can be seen that 危 PPCPs in groundwater sampling sites in the Pearl River Delta are between 33.53ng / L of NDN, and the total detectable concentration range of single target substances is 0.24 ~ 52.84 ng / L, the main pollutants are CF and IM.The contents of groundwater in villages and suburbs of cities are investigated. The degree of PPCPs pollution is in order of Guangzhou Foshan Qingyuan Dongguan and the pollution of PPCPs in groundwater by leather factories is more serious than that in electronic processing plants. This study provides a scientific basis for the study of PPCPs concentration, pollution status, risk assessment, source analysis and prevention and control in typical pollution sources and groundwater in the Pearl River Delta region by relevant departments and researchers at home and abroad.
【學位授予單位】：湖南師范大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：X523;X501

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本文編號：2051455