本文選題：6-氨基青霉烷酸 + 液膜技術(shù)　； 參考：《天津大學(xué)》2015年碩士論文

【摘要】：6-氨基青霉烷酸,簡(jiǎn)稱(chēng)6-APA,是合成各種半合成青霉素類(lèi)藥物的重要中間體,具有廣泛的應(yīng)用和廣闊的市場(chǎng)。6-APA工業(yè)上主要由生物酶法合成,其具有反應(yīng)條件溫和、轉(zhuǎn)化率高、污染少等諸多優(yōu)點(diǎn)。6-APA的分離提純主要選用結(jié)晶工藝,而結(jié)晶母液中會(huì)有少量的6-APA殘留。這種低濃度的6-APA溶液直接排放不僅造成了資源浪費(fèi),同時(shí)提高了環(huán)保處理費(fèi)用。由此,本文研究了應(yīng)用液膜技術(shù)來(lái)處理低濃度的6-APA溶液,以實(shí)現(xiàn)的工業(yè)廢液中6-APA的高效回收。首先,以6-APA稀溶液為研究對(duì)象,通過(guò)實(shí)驗(yàn)研究了厚體液膜絡(luò)合萃取回收6-APA的傳質(zhì)過(guò)程,確定了厚體液膜絡(luò)合萃取過(guò)程實(shí)驗(yàn)條件下的較優(yōu)條件,并對(duì)厚體液膜絡(luò)合萃取動(dòng)力學(xué)進(jìn)行了研究。結(jié)果表明:取得實(shí)驗(yàn)條件下最佳萃取效果時(shí)原料相的pH為6.2左右;混合有機(jī)萃取劑中載體甲基三辛基氯化銨的較優(yōu)濃度為0.70 mol/L;混合萃取劑:原料相:反萃相=0.8:1:1(體積比);反萃相的較佳pH為1.5左右;反萃相為KCl的鹽溶液,氯離子較優(yōu)濃度為1mol/L。其次,應(yīng)用反萃相預(yù)分散式中空纖維支撐液膜(HFSLM-SD)萃取技術(shù)來(lái)處理低濃度6-APA溶液的過(guò)程。通過(guò)實(shí)驗(yàn)研究確定了實(shí)驗(yàn)條件下下HFSLM-SD的較優(yōu)條件。結(jié)果表明:反萃相攪拌速率最佳為300rpm;較優(yōu)的管程原料相流量150ml/min;殼程反萃相流量選擇125ml/min;實(shí)驗(yàn)適宜的跨膜壓差為6psi。通過(guò)4次連續(xù)實(shí)驗(yàn)對(duì)液膜穩(wěn)定性進(jìn)行了研究,說(shuō)明了本實(shí)驗(yàn)中支撐液膜的連續(xù)性操作和支撐液膜的液膜穩(wěn)定性都具有良好的效果。最后,通過(guò)對(duì)HFSLM-SD萃取6-APA的過(guò)程進(jìn)行傳質(zhì)分析,對(duì)傳質(zhì)過(guò)程進(jìn)行了合理假設(shè),并在此基礎(chǔ)上建立了總傳質(zhì)系數(shù)模型。得到穩(wěn)態(tài)下進(jìn)料側(cè)、膜內(nèi)、反萃側(cè)傳質(zhì)系數(shù)和總傳質(zhì)系數(shù)分別為得到得到kw=3.51×10-6 m/s,km=1.81×10-6m/s,ks=6.52×10-6 m/s,總傳質(zhì)系數(shù)K=1.18×10-6 m/s,說(shuō)明中空纖維膜絡(luò)合萃取6-APA的傳質(zhì)過(guò)程中的阻力主要集中在跨膜傳質(zhì)過(guò)程中;通過(guò)對(duì)比實(shí)驗(yàn)過(guò)程中原料相6-APA濃度隨時(shí)間變化,驗(yàn)證了模型的準(zhǔn)確性。本文運(yùn)用液膜技術(shù)耦合絡(luò)合萃取對(duì)低濃度6-APA溶液的處理進(jìn)行了實(shí)驗(yàn)研究,取得了一定效果,可為其他學(xué)者在低濃度6-APA的處理工藝研究以及液膜技術(shù)的應(yīng)用研究提供一定借鑒。
[Abstract]:6-aminopenicillanic acid, or 6-APA, is an important intermediate for the synthesis of various semi-synthetic penicillin drugs. It is widely used and widely marked.6-APA is mainly synthesized by biological enzyme method in industry, and its reaction conditions are mild and the conversion rate is high. The separation and purification of 6-APA, such as less pollution and so on, mainly use crystallization process, and there will be a small amount of 6-APA residue in the crystallization mother liquor. The direct discharge of this low concentration of 6-APA solution not only results in waste of resources, but also increases the cost of environmental protection treatment. Therefore, the application of liquid membrane technology to the treatment of low concentration of 6-APA solution was studied in order to realize the efficient recovery of 6-APA from industrial waste liquor. Firstly, the mass transfer process of 6-APA recovery by thick humoral membrane complexation extraction was studied by using 6-APA dilute solution as the research object, and the optimum conditions were determined under the experimental conditions. The complex extraction kinetics of thick humoral membrane was studied. The results show that the pH of the raw material phase is about 6.2 when the optimum extraction effect is obtained under the experimental conditions. The optimum concentration of methyl trioctyl ammonium chloride in the mixed organic extractant is 0.70 mol / L, and the optimum concentration of mixed extractant is 0.8: 1: 1: 1 (volume ratio); the optimum pH of the stripping phase is about 1.5; the optimum concentration of chlorine ion is 1 / mol / L in the salt solution of KCl and the optimum concentration of chlorine ion is 1 / mol / L. Secondly, the extraction process of low concentration 6-APA solution was studied by using the stripping phase predispersive hollow fiber supporting liquid membrane HFSLM-SD extraction technology. The optimal conditions of HFSLM-SD under experimental conditions were determined by experimental study. The results show that the optimum stirring rate of stripping phase is 300rpm, the optimal flow rate of raw material phase is 150ml / min, the flow rate of shell stripping phase is 125ml / min, and the suitable pressure difference is 6psi. The stability of liquid film was studied through four continuous experiments. The results show that the continuous operation of supporting liquid membrane and the stability of liquid film of supporting liquid membrane have good effect in this experiment. Finally, through the mass transfer analysis of HFSLM-SD extraction of 6-APA, the reasonable assumption of mass transfer process is made, and the model of total mass transfer coefficient is established. The mass transfer coefficient and total mass transfer coefficient of feed side, inside membrane and back extraction side were obtained as follows: kw=3.51 脳 10-6 m / s / s = 1.81 脳 10 ~ (-6) m / s / s, total mass transfer coefficient K ~ (-1) = 1.18 脳 10 ~ (-6) m / s, respectively, indicating that the resistance in the process of mass transfer in 6-APA extraction by hollow fiber membrane complexation was mainly concentrated in the process of transmembrane mass transfer. The accuracy of the model was verified by comparing the 6-APA concentration of raw material phase with time. In this paper, the treatment of low concentration 6-APA solution with liquid membrane technique coupled with complex extraction has been studied experimentally, and some results have been obtained, which can be used for reference by other scholars in the treatment process of low concentration 6-APA and the application research of liquid membrane technology.
【學(xué)位授予單位】：天津大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：X787;TQ028.8

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本文編號(hào)：1970256