本文選題：環(huán)肽納米管 + 自組裝��； 參考：《南京信息工程大學(xué)》2015年碩士論文

【摘要】：本論文首先以4-溴鄰苯二胺和叔丁氧羰基(Boc)-保護的L-和D-型苯丙氨酸為原料,采用傳統(tǒng)的液相合成法制成線型多肽,然后將線型多肽與鄰苯二甲酰氯為原料合成環(huán)狀多肽；將純化的環(huán)肽結(jié)構(gòu)單元進行環(huán)肽納米管的自組裝,利用傅立葉紅外光譜儀(FT-IR)、掃描電子顯微鏡(SEM)、原子力顯微鏡(AFM)、透射電子顯微鏡(TEM)等方法對其表征。以3,5-二溴苯乙酮為原料通過三聚反應(yīng)、功能團保護和脫保護的反應(yīng)方法完成含多功能團具有π-共軛結(jié)構(gòu)的中心核分子的合成。研究結(jié)果表明：采用液相合成法成功地合成兩個具有不同旋光性的環(huán)六肽和一種環(huán)八肽結(jié)構(gòu)單元。BET的結(jié)果表明L型的環(huán)六肽的比表面積大于D型的環(huán)六肽。對純化后的環(huán)肽結(jié)構(gòu)單元在三氟乙酸(TFA)和去離子水兩相條件下進行自組裝研究,發(fā)現(xiàn)L-型的環(huán)六肽比D-型的自組裝速度要快,環(huán)8肽的自組裝速率介于兩者之間；聚集的環(huán)六肽納米管環(huán)肽8-D的自組裝材料是平均直徑為0.90μm的網(wǎng)狀物；環(huán)肽8-D的自組裝材料是平均直徑為0.78μm的網(wǎng)狀物,其中含有空心管柱狀結(jié)構(gòu)。3,5-二溴苯乙酮為原料通過三聚反應(yīng)是以四氯化硅為催化劑、無水乙醇為溶液室溫下反應(yīng)的,得到1,3,5-三(3,5-二溴苯基)苯。采用Pd/Cu催化體系的Sonogashira偶聯(lián)反應(yīng)和甲醇／四氫呋喃／氫氧化鉀的脫保護體系得到含多功能團具有π-共軛結(jié)構(gòu)的中心核分子。
[Abstract]:In this paper, 4- bromo o-phenyl-o-phenyl-two amine and tert oxo carbonyl (Boc) - protected L- and D- phenylalanine were used as raw materials to form linear polypeptides by traditional liquid phase synthesis method. Then the linear polypeptide and phthalic two Methoyl chloride were used as raw materials to synthesize cyclic peptides. The purified cyclic peptide structure unit was used for self-assembly of cyclic peptide nanotubes, and Fu Li was used. FT-IR, scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscope (TEM) and other methods were used to characterize them. The synthesis of central nucleation molecules with pion conjugated structures with multi-functional groups was completed by the trimeric reaction of 3,5- two bromoacetophenone as raw material, functional regiment protection and deprotection. The results showed that two cyclic six peptide and one ring eight peptide structure unit.BET with different optical rotation were synthesized by liquid phase synthesis. The results showed that the specific surface area of L type ring six peptide was greater than that of D type ring six peptide. The self-assembly of the purified cyclic peptide structure unit under the condition of three FLUOROACETIC acid (TFA) and deionization subwater was studied, and L was found. The self assembly rate of the type six peptide is faster than that of the D- type, and the self assembly rate of the ring 8 peptide is between the two. The aggregated ring six peptide 8-D's self assembled material is a network with an average diameter of 0.90 u m; the self assembled material of the cyclic peptide 8-D is a network with an average diameter of 0.78 mu m, which contains the hollow tube columnar structure of.3,5- dibromine. 1,3,5- three (3,5- dibromophenyl) benzene was obtained by the tripolymerization of four silicon chloride as the catalyst and ethanol as the reaction at room temperature. The Sonogashira coupling reaction and the deprotector of methanol / tetrahydrofuran / potassium hydroxide in the Pd/Cu catalytic system were used to obtain the pion conjugated structure containing the multi-functional group. Nucleus of the heart.

【學(xué)位授予單位】：南京信息工程大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：TB383.1;X51

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