基于壓電振蕩原理的微陣列點樣系統(tǒng)的研制
發(fā)布時間：2018-07-16 18:38
【摘要】：針對基于電磁微閥原理的非接觸點樣方式存在操作過程復雜、點樣量偏大,以及壓電噴墨原理的非接觸點樣方式存在點樣針不易清洗、造價昂貴等不足,研制了一種基于壓電振蕩原理的新型非接觸點樣裝置,實現(xiàn)了微量液體點樣。在本裝置中,毛細管點樣針與壓電驅(qū)動裝置為兩個獨立單元,可以單獨對毛細管點樣針進行更換和清洗。采用激光拉制法制備的玻璃毛細管點樣針具有內(nèi)徑可調(diào)、成本低等優(yōu)點。此點樣方式通過改變壓電陶瓷的振幅和頻率,可在10~(-10)~10~(-9)L之間調(diào)控點樣體積。以此為基礎,結(jié)合三維精密位移控制技術(shù),研制了一種基于壓電振蕩原理的微陣列生物芯片點樣系統(tǒng)。對點樣系統(tǒng)的點樣體積、點樣密度、點樣精度等參數(shù)進行了測試,結(jié)果表明,此點樣系統(tǒng)的最小點樣體積可達320 pL,點樣密度可達4000點/cm~2,并能夠?qū)崿F(xiàn)界面圖案化制備。
[Abstract]:In this paper, a new non contact sample device based on the principle of piezoelectric oscillation is developed for the non contact point pattern based on the principle of electromagnetic micro valve, such as complicated operation process, large amount of point sample and non contact point pattern of piezoelectric ink-jet principle. In the device, the capillary point needle and the piezoelectric driving device are two independent units, which can be replaced and cleaned separately. The glass capillary point needle prepared by laser drawing has the advantages of adjustable inner diameter and low cost. By changing the amplitude and frequency of the piezoceramic, it can be in 10~ (-10) ~10~ (-9) L. On the basis of this, a microarray biological chip sampling system based on the principle of piezoelectric oscillations is developed on the basis of three dimensional precision displacement control technology. The point sample size, point sample density and point sample precision are tested. The results show that the minimum sample size of the point sample system can reach 320 pL, The sample density can reach 4000 /cm~2, and the interface patterning can be achieved.
【作者單位】： 長春理工大學光電工程學院;中國科學院長春應用化學研究所;
【基金】：中國科學院科研裝備研制項目(No.YZ201355)資助
【分類號】：TN492
本文編號：2127285
[Abstract]:In this paper, a new non contact sample device based on the principle of piezoelectric oscillation is developed for the non contact point pattern based on the principle of electromagnetic micro valve, such as complicated operation process, large amount of point sample and non contact point pattern of piezoelectric ink-jet principle. In the device, the capillary point needle and the piezoelectric driving device are two independent units, which can be replaced and cleaned separately. The glass capillary point needle prepared by laser drawing has the advantages of adjustable inner diameter and low cost. By changing the amplitude and frequency of the piezoceramic, it can be in 10~ (-10) ~10~ (-9) L. On the basis of this, a microarray biological chip sampling system based on the principle of piezoelectric oscillations is developed on the basis of three dimensional precision displacement control technology. The point sample size, point sample density and point sample precision are tested. The results show that the minimum sample size of the point sample system can reach 320 pL, The sample density can reach 4000 /cm~2, and the interface patterning can be achieved.
【作者單位】： 長春理工大學光電工程學院;中國科學院長春應用化學研究所;
【基金】：中國科學院科研裝備研制項目(No.YZ201355)資助
【分類號】：TN492
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