本文關(guān)鍵詞：鋰皂石基抗菌材料的制備及其性能的研究　出處：《天津工業(yè)大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 鋰皂石 殼聚糖 抗菌性能 β-環(huán)糊精

【摘要】：近年來(lái),隨著社會(huì)的快速發(fā)展和人們生活水平的提高,人們對(duì)生活品質(zhì)的要求也越來(lái)越高,但是細(xì)菌、霉菌等有害微生物卻時(shí)時(shí)刻刻的威脅著我們的生活。因此亟待研究出一種高效的抗菌材料。本課題選用一種相比于其他硅酸鹽具有較大的比表面積、較高的陽(yáng)離子交換容量和顯著的膨脹性能的新型層狀硅酸鹽-鋰皂石為原料,分別采用溶液插層法和表面改性法對(duì)其進(jìn)行改性,從而制備具有吸附菌和殺菌雙重功效的鋰皂石。首先采用溶液插層法對(duì)鋰皂石進(jìn)行改性,利用多種季銨鹽改性鋰皂石,通過(guò)XRD和抗菌性能強(qiáng)弱逐級(jí)篩選,得出最佳的制備工藝,即反應(yīng)溫度為80℃,最佳的反應(yīng)時(shí)間為8 h,反應(yīng)比例為1:2。然后以十四烷基三甲基溴化銨、十六烷基三甲基溴化銨、殼聚糖和鋰皂石為原料制備殼聚糖/有機(jī)鋰皂石復(fù)合物,運(yùn)用FTIR、XRD、SEM、TEM等分析手段對(duì)其結(jié)構(gòu)和形貌特征進(jìn)行了表征。利用抑菌圈、平板計(jì)數(shù)法、TTC顯色和內(nèi)膜滲透性等對(duì)殼聚糖/有機(jī)鋰皂石復(fù)合物的抗菌性能進(jìn)行分析。其次,實(shí)驗(yàn)采用表面改性的方法使鋰皂石表面接枝β-環(huán)糊精,首先利用硅烷偶聯(lián)劑制備胺基化有機(jī)鋰皂石,然后利用丁二酸酐制備羧基化有機(jī)鋰皂石,最后制備出β-環(huán)糊精接枝有機(jī)鋰皂石,并研究pH和初始濃度對(duì)β-環(huán)糊精接枝有機(jī)鋰皂石的包封率的影響。利用多種表征手段對(duì)產(chǎn)物的結(jié)構(gòu)、抗菌性能、藥物釋放動(dòng)力學(xué)等方面進(jìn)行研究。本研究成功利用兩種改性方法完成了對(duì)鋰皂石的改性,制備的殼聚糖/十四烷基三甲基溴化銨/鋰皂石對(duì)大腸桿菌的抗菌率為100.0%,對(duì)金黃色葡萄球菌的抗菌率為85.3%,殼聚糖/十六烷基三甲基溴化銨/鋰皂石對(duì)大腸桿菌的抗菌率為99.9%,對(duì)金黃色葡萄球菌的抗菌率為99.9%。制備的氨芐青霉素/β-環(huán)糊精接枝有機(jī)鋰皂石對(duì)大腸桿菌的抗菌率為95.9%,對(duì)金黃色葡萄球菌的抗菌率為100.0%,其藥物釋放機(jī)制為Fick擴(kuò)散。
[Abstract]:In recent years, with the rapid development of society and the improvement of people's living standard, people's request for quality of life is higher and higher, but bacteria. The harmful microorganism such as mold is threatening our life all the time. Therefore, it is urgent to develop a kind of high efficiency antibacterial material. In this study, one kind of silicate has a larger specific surface area than other silicate. The new layered silicate-lithium-soap with high cation exchange capacity and remarkable expansibility was modified by solution intercalation method and surface modification method respectively. In order to prepare lithium-soaponite with adsorption bacteria and bactericidal effect. Firstly, the lithium-soaponite was modified by solution intercalation method, and the lithium-saponite was modified by a variety of quaternary ammonium salts. The XRD and antibacterial properties were screened step by step. The optimum preparation process was obtained, that is, the reaction temperature was 80 鈩，

本文編號(hào)：1411533