本文選題：離心訓(xùn)練 + 骨骼肌細(xì)胞外基質(zhì)�。� 參考：《曲阜師范大學(xué)》2017年碩士論文

【摘要】：1目的:2型糖尿病是最常見的非傳染性慢性疾病,被認(rèn)為是一種運動缺乏的疾病。運動作為預(yù)防或治療2型糖尿病的較好手段,在促進(jìn)身體健康、降低糖尿病發(fā)病率的過程中起著積極作用。目前,2型糖尿病的運動干預(yù)手段有三種形式,即耐力訓(xùn)練、抗阻力訓(xùn)練以及耐力-抗阻力混合訓(xùn)練,其中任何一種訓(xùn)練方式均具有療效,部分學(xué)者認(rèn)為離心抗阻力訓(xùn)練優(yōu)越于其他運動形式。本研究采用離心抗阻力訓(xùn)練模式,旨在研究離心訓(xùn)練治療2型糖尿病患者的療效問題。2方法:選取26名2型糖尿病患者作為研究對象,隨機分為對照組與離心抗阻力訓(xùn)練組。離心抗阻力訓(xùn)練組訓(xùn)練8周,每周3次,訓(xùn)練方案:1-2周為12RM、離心收縮對抗10s;3-4周為12RM、離心收縮對抗12s;5-6周為12RM、離心收縮對抗15s;7-8周為12RM、離心收縮對抗17s。對照組與離心抗阻力訓(xùn)練組在訓(xùn)練前1周和末次訓(xùn)練后隔日清晨采集肘正中靜脈血樣,檢測血常規(guī)(白細(xì)胞、中性粒細(xì)胞、淋巴細(xì)胞和血小板計數(shù))、空腹血糖、胰島素、糖化血紅蛋白、甘油三脂、總膽固醇、高密度脂蛋白-膽固醇、低密度脂蛋白-膽固醇、基質(zhì)金屬蛋白酶-2、基質(zhì)金屬蛋白酶-9、羥脯氨酸和肌酸激酶濃度變化。3結(jié)果:3.1與健康受試者相比,2型糖尿病患者臨床參數(shù)具體變化是:(1)空腹血糖、胰島素、和糖化血紅蛋白呈極顯著性升高(P0.001),甘油三脂、總膽固醇、高密度脂蛋白-膽固醇及胰島素抵抗指數(shù)呈顯著性升高(P0.05,P0.001);(2)白細(xì)胞計數(shù)呈非常顯著性增加(P0.01),中性粒細(xì)胞計數(shù)以及中性粒細(xì)胞計數(shù)與淋巴細(xì)胞計數(shù)比率呈顯著性增加(P0.05);(3)基質(zhì)金屬蛋白酶2和9濃度呈非常顯著性升高(分別為P0.01、P0.001)。3.2離心抗阻力訓(xùn)練組與對照組2型糖尿病受試者代謝相關(guān)指標(biāo)組內(nèi)變化分別為:與10周前相比,(1)離心抗阻力訓(xùn)練組2型糖尿病受試者空腹血糖、胰島素濃度呈顯著性降低(P0.05),胰島素抵抗指數(shù)呈非常顯著性降低(P0.01),糖化血紅蛋白值呈極顯著性降低(P0.001);(2)2型糖尿病對照組受試者空腹血糖、胰島素、糖化血紅蛋白以及胰島素抵抗指數(shù)均無顯著性變化(P0.05)。離心抗阻力訓(xùn)練組與對照組2型糖尿病受試者代謝相關(guān)指標(biāo)組間變化為:與對照組2型糖尿病受試者相比,離心抗阻力訓(xùn)練組空腹血糖呈現(xiàn)顯著下降的趨勢(P=0.07),胰島素濃度、糖化血紅蛋白值和胰島素抵抗指數(shù)均無顯著性變化(P0.05),但胰島素濃度、糖化血紅蛋白值和胰島素抵抗指數(shù)分別下降37%、7%和39%。3.3離心抗阻力訓(xùn)練組與對照組2型糖尿病受試者基質(zhì)金屬蛋白酶2和9和羥脯氨酸濃度組內(nèi)變化分別為:與10周前相比,(1)離心抗阻力訓(xùn)練組2型糖尿病受試者血清中基質(zhì)金屬蛋白酶2濃度呈顯著性降低(P0.05),基質(zhì)金屬蛋白酶9濃度呈顯著性升高(P0.05),羥脯氨酸濃度呈非常顯著性升高(P0.01);(2)2型糖尿病對照組受試者血清基質(zhì)金屬蛋白酶2濃度非常顯著性降低(P0.05),基質(zhì)金屬蛋白酶9和羥脯氨酸濃度無顯著性變化(P0.05)。離心抗阻力訓(xùn)練組與對照組2型糖尿病受試者基質(zhì)金屬蛋白酶2和9和羥脯氨酸濃度組間變化為:與對照組2型糖尿病受試者相比,離心抗阻力訓(xùn)練組血清中基質(zhì)金屬蛋白酶2的濃度呈顯著性降低(P0.05),基質(zhì)金屬蛋白酶9濃度呈非常顯著性升高(P0.01),羥脯氨酸濃度呈極顯著性升高(P0.001)。4結(jié)論:4.1離心抗阻力訓(xùn)練可以降低2型糖尿病患者的空腹血糖、胰島素、Hb A1c和胰島素抵抗指數(shù),提高胰島素敏感性。4.2離心抗阻力訓(xùn)練下調(diào)了血液中基質(zhì)金屬蛋白酶-2濃度,增加了基質(zhì)金屬蛋白酶-9濃度。4.3離心抗阻力訓(xùn)練可以改善2型糖尿病癥狀,與基質(zhì)金屬蛋白酶濃度變化有關(guān)。
[Abstract]:1 Objective: type 2 diabetes is the most common non communicable chronic disease, which is considered to be a lack of exercise. Exercise is a good means to prevent or treat type 2 diabetes. It plays an active role in promoting health and reducing the incidence of diabetes. At present, there are three forms of exercise intervention for type 2 diabetes, that is, resistance to diabetes. Force training, resistance training and endurance resistance mixed training, of which any one of the training methods are effective, some scholars believe that centrifugal resistance training is superior to other forms of exercise. In this study, centrifugal resistance training model was used to study the effect of centrifugal training in the treatment of type 2 diabetes patients.2 method: 26 The patients with type 2 diabetes were randomly divided into the control group and the centrifugal resistance training group. The centrifuge resistance training group was trained for 8 weeks, 3 times a week, the training program was 12RM, the centrifugal contraction against 10s, the 3-4 week 12RM, the centrifugal contraction against 12s, the 5-6 week 12RM, the centrifugal contraction against 15s, the 7-8 week 12RM, and the centrifugal contractions against 17s. control. The group and the centrifugal resistance training group collected the median vein blood samples of the elbow in the early morning 1 weeks before and after the last training, and tested the blood routine (leukocyte, neutrophils, lymphocyte and platelet count), fasting blood glucose, insulin, glycated hemoglobin, glycerol three fat, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein - gallbladder. Sterol, matrix metalloproteinase -2, matrix metalloproteinase -9, hydroxyproline and creatine kinase concentration changes.3 results: 3.1 compared with healthy subjects, the specific changes in clinical parameters of patients with type 2 diabetes were: (1) hyperglycemia, insulin, and glycated hemoglobin were significantly elevated (P0.001), glycerol three fat, total cholesterol, high density lipoprotein The index of cholesterol and insulin resistance increased significantly (P0.05, P0.001); (2) the white cell count increased significantly (P0.01), neutrophils count, neutrophils count and lymphocyte count ratio increased significantly (P0.05), (3) the concentration of matrix metalloproteinase 2 and 9 increased significantly (P0.01, P0.001, respectively) .3.2 centrifuge resistance training group and the control group of type 2 diabetic subjects were compared with those in the control group: compared with 10 weeks ago, (1) the concentration of insulin was significantly decreased (P0.05), the insulin resistance index was significantly decreased (P0.01), and the glycated hemoglobin value was significantly reduced. There was a very significant decrease (P0.001); (2) there was no significant change in fasting blood glucose, insulin, glycosylated hemoglobin and insulin resistance index in the control group of type 2 diabetes mellitus. The changes in metabolic related indexes between the centrifugal resistance training group and the control group of type 2 diabetic subjects were compared with those in the control group of type 2 diabetic subjects. There was a significant decrease in fasting blood glucose in the anti resistance training group (P=0.07), insulin concentration, glycosylated hemoglobin value and insulin resistance index had no significant changes (P0.05), but insulin concentration, glycosylated hemoglobin value and insulin resistance index decreased by 37%, 7% and 39%.3.3 centrifuge resistance training group and control group 2 type diabetes. The changes of matrix metalloproteinase 2 and 9 and hydroxyproline concentration in the subjects were as follows: compared with 10 weeks ago, (1) the concentration of matrix metalloproteinase 2 in the serum of type 2 diabetic subjects was significantly decreased (P0.05), the concentration of matrix metalloproteinase 9 was significantly increased (P0.05), and the concentration of hydroxyproline was very significant. The concentration of matrix metalloproteinase 2 was significantly decreased (P0.05) and the concentration of matrix metalloproteinase 9 and hydroxyproline was not significantly changed (P0.05) in the subjects of type 2 diabetes control group (2). The concentration of matrix metalloproteinase 2 and 9 and hydroxyproline in the control group and the control group of type 2 diabetic subjects were significantly different from those in the control group. Compared with the control group of type 2 diabetes, the concentration of matrix metalloproteinase 2 in serum of centrifugal resistance training group decreased significantly (P0.05), the concentration of matrix metalloproteinase 9 increased significantly (P0.01), the concentration of hydroxyproline was significantly increased (P0.001).4 conclusion: 4.1 centrifuge resistance training can reduce the type of sugar 2 Fasting blood glucose, insulin, Hb A1c and insulin resistance index in patients with urinary disease, increasing insulin sensitivity.4.2 centrifugal resistance training down regulated the concentration of matrix metalloproteinase -2 in the blood, and increased the concentration of matrix metalloproteinase -9 in.4.3 centrifugal resistance training to improve the symptoms of type 2 diabetes, and the change of matrix metalloproteinase concentration Of
【學(xué)位授予單位】：曲阜師范大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R587.1;G808.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 張學(xué)林;王瑞元;;過度使用性損傷發(fā)生機制:骨骼肌張力整合復(fù)合體失衡學(xué)說[J];中國運動醫(yī)學(xué)雜志;2013年07期

2 張翔;張學(xué)林;許壽生;;運動與骨骼肌超微結(jié)構(gòu)變化[J];中國運動醫(yī)學(xué)雜志;2010年01期

相關(guān)碩士學(xué)位論文 前1條

1 張翔;橫向張力傳遞在針刺干預(yù)運動性骨骼肌微損傷效應(yīng)中的作用研究[D];曲阜師范大學(xué);2016年

，

本文編號：2063971