本文選題：衰老性肌萎縮 + 肌力康復(fù)訓(xùn)練�。� 參考：《武漢體育學(xué)院》2017年碩士論文

【摘要】：研究目的衰老性肌萎縮不僅是指骨骼肌質(zhì)量下降,也包括肌肉機能逐漸下降,力量下降、最大收縮速度下降以及收縮和舒張普遍變慢。在我國人口老年化的背景下,老年人群發(fā)生跟衰老性相關(guān)的疾病呈日益增長的趨勢,其中關(guān)于衰老性肌萎縮的深入研究和治療方法已成為一個具有潛在威脅的問題,并越來越會引起重視。但選取合適的預(yù)防衰老性肌萎縮的干預(yù)方案依然是有待解決的問題。因此,研究出切實可行的訓(xùn)練方案對干預(yù)老年人肌萎縮有著非常重要的意義。研究方法本研究對象選自武漢市紫陽湖敬老院中15名患有衰老性肌萎縮的老年人,其中男性8人,女性7人。以EWGSOP(歐洲老年人衰老性肌萎縮研究團(tuán)隊)發(fā)布的標(biāo)準(zhǔn)為依據(jù),進(jìn)行身體機能指標(biāo)測試和生化血液指標(biāo)的采集,身體機能指標(biāo)包括:握力(男子"f30kg,女子"f20kg)、骨骼肌質(zhì)量(男子"f10.76 kg/m2,女子"f6.76kg/m2)和4米步速(男/女"f1 m/s),生化血液指標(biāo)包括:超氧化物歧化酶(SOD)、胰島素生長因子-1(IGF-1)、肌肉生長抑制素(MSTN)、腫瘤壞死因子α(TNF-α)。通過進(jìn)行12周的肌力康復(fù)訓(xùn)練,比較肌力康復(fù)訓(xùn)練對衰老性肌萎縮患者的身體機能指標(biāo)及生化血液指標(biāo)的影響效果,為衰老性肌萎縮患者制定科學(xué)合理的運動方案奠定基礎(chǔ)。結(jié)果:(1)通過12周的肌力康復(fù)訓(xùn)練后,對比男性老年人干預(yù)前后的身體機能指標(biāo),表現(xiàn)為:干預(yù)后的男性老年人握力顯著大于干預(yù)前(P0.01);干預(yù)后男性老年人四米步速顯著高于干預(yù)前(P0.01);而干預(yù)后男性老年人骨骼肌質(zhì)量指數(shù)SMI與干預(yù)前無顯著性差異(P0.05)。(2)通過12周的肌力康復(fù)訓(xùn)練后,對比男性老年人干預(yù)前后的血液指標(biāo),表現(xiàn)為:干預(yù)后男性老年人胰島素樣生長因子-1(IGF-1)無顯著性差異(P0.05),干預(yù)后男性老年人肌肉生長抑制素(MSTN)、腫瘤壞死因子α(TNF-α)均顯著低于干預(yù)前(P0.01,P0.05),干預(yù)后男性老年人超氧化物歧化酶(SOD)顯著高于干預(yù)前(P0.01)。(3)通過12周的肌力康復(fù)訓(xùn)練后,對比女性老年人干預(yù)前后的身體機能指標(biāo),表現(xiàn)為:干預(yù)后的女性老年人握力顯著大于干預(yù)前(P0.01);干預(yù)后女性老年人四米步速顯著高于干預(yù)前(P0.01);而干預(yù)后女性老年人骨骼肌質(zhì)量指數(shù)SMI與干預(yù)前無顯著性差異(P0.05)。(4)通過12周的肌力康復(fù)訓(xùn)練后,對比女性老年人干預(yù)前后的血液指標(biāo),表現(xiàn)為:干預(yù)后女性老年人胰島素樣生長因子-1(IGF-1)無顯著性差異(P0.05),干預(yù)后女性老年人肌肉生長抑制素(MSTN)、腫瘤壞死因子α(TNF-α)均顯著低于干預(yù)前(P0.01,P0.05),干預(yù)后女性老年人超氧化物歧化酶(SOD)顯著高于干預(yù)前(P0.05)。結(jié)論:(1)肌力康復(fù)訓(xùn)練對男性老年人的衰老性肌萎縮的身體機能指標(biāo)握力和四米步速影響明顯,對骨骼肌質(zhì)量指數(shù)SMI診斷指標(biāo)診斷影響不明顯,表現(xiàn)為干預(yù)后握力增加,四米步速上升,但骨骼肌質(zhì)量指數(shù)SMI則沒有顯著性變化。對男性老年人的衰老性肌萎縮血清指標(biāo)中MSTN、SOD、TNF-α影響明顯,對血清指標(biāo)IGF-1影響不明顯,表現(xiàn)為干預(yù)后MSTN、TNF-α指標(biāo)下降,SOD指標(biāo)上升,而IGF-1指標(biāo)則沒有顯著性變化。(2)肌力康復(fù)訓(xùn)練對女性老年人的衰老性肌萎縮的身體機能指標(biāo)握力和四米步速影響明顯,對骨骼肌質(zhì)量指數(shù)SMI診斷指標(biāo)診斷影響不明顯,表現(xiàn)為干預(yù)后握力增加,四米步速上升,但骨骼肌質(zhì)量指數(shù)SMI則沒有顯著性變化。對女性老年人的衰老性肌萎縮血清指標(biāo)中MSTN、SOD、TNF-α影響明顯,對血清指標(biāo)IGF-1影響不明顯,表現(xiàn)為干預(yù)后MSTN、TNF-α指標(biāo)下降,SOD指標(biāo)上升,而IGF-1指標(biāo)則沒有顯著性變化。
[Abstract]:Objective aging muscle atrophy not only refers to the decline in skeletal muscle mass, but also the gradual decline in muscle function, the decline of strength, the decrease of the maximum contraction speed and the widespread slow contraction and relaxation. In the background of the aging of the population in China, the aging related diseases are growing more and more, among them aging sex The in-depth study and treatment of muscular atrophy have become a potential threat, and more and more attention will be paid. However, it is still a problem to be solved to select the appropriate intervention scheme to prevent aging muscle atrophy. Therefore, it is of great significance to study the practical training program for the intervention of the elderly. In this study, 15 elderly people with aging myatrophy were selected from the elderly hospital of Ziyang Lake in Wuhan, including 8 men and 7 women. Based on the standards issued by the EWGSOP (European seniors aging muscle atrophy research team), the body function test and biochemical blood indexes were collected, and the physical function indexes included: Grip strength (men's "f30kg, women" f20kg), skeletal muscle mass (men's "f10.76 kg/m2, women" f6.76kg/m2) and 4 meter gait (male / female "F1 m/s), biochemical blood indicators include: superoxide dismutase (SOD), insulin growth factor -1 (IGF-1), myostatin (MSTN), tumor necrosis factor alpha (TNF- alpha). Through 12 weeks of muscle strength rehabilitation training, To compare the effect of muscle strength rehabilitation training on the body function index and biochemical blood indexes of senescent amyotrophic patients and lay the foundation for the formulation of scientific and reasonable exercise program for senile amyotrophic patients. Results: (1) after 12 weeks of muscle strength rehabilitation training, the physical function indexes before and after the intervention of male elderly people were compared. The grip strength of the male elderly was significantly higher than that before the intervention (P0.01), and the four meter gait of the male elderly was significantly higher than that before the intervention (P0.01), while the skeletal muscle mass index (SMI) of the male elderly was not significantly different from that before the intervention (P0.05). (2) after 12 weeks of muscle rehabilitation training, the blood indexes before and after the intervention of the male elderly were compared. There was no significant difference between the male elderly and the insulin-like growth factor -1 (IGF-1) after the dry prognosis (P0.05). The prognosis of the male elderly with myostatin (MSTN) and tumor necrosis factor alpha (TNF- alpha) were significantly lower than that before intervention (P0.01, P0.05) after the dry prognosis (P0.01, P0.05). After intervention, the superoxide dismutase (SOD) of male elderly was significantly higher than that before intervention (P0.01). (3) through the intervention (3) After 12 weeks of muscle rehabilitation training, the index of body function before and after the intervention of the female elderly was compared. The grip strength of the female elderly was significantly higher than that before the intervention (P0.01), and the four meter gait of the female elderly was significantly higher than that before the intervention (P0.01), while the skeletal muscle mass index (SMI) of the female elderly was not significant before the intervention. Difference (P0.05). (4) after 12 weeks of muscle strength rehabilitation training, the blood indexes before and after the intervention of female elderly were compared. There was no significant difference (P0.05) in the female elderly patients with insulin like growth factor (IGF-1) after the intervention (P0.05), and the prognosis of the female elderly with myostatin (MSTN) and the tumor necrosis factor alpha (TNF- alpha) were significantly lower than those before the intervention. (P0.01, P0.05), the prognosis of female elderly patients with superoxide dismutase (SOD) was significantly higher than that before the intervention (P0.05). Conclusion: (1) the effect of muscle strength rehabilitation training on the body function index of aging myatrophy and four meter speed is obviously affected, and the diagnosis of skeletal muscle mass index SMI is not significantly affected, and it is the post intervention grip. The strength increased at four meters, but there was no significant change in the skeletal muscle mass index SMI. The effect of MSTN, SOD, TNF- alpha on the serum index of aging myatrophy in male elderly was obvious, and the effect on serum index IGF-1 was not obvious, and the prognosis was MSTN, TNF- a index decreased, SOD index increased, but the IGF-1 index had no significant change. (2) The effect of muscle strength rehabilitation training on the body function index of aging muscle atrophy of female elderly was obvious, and the influence on the diagnosis index of skeletal muscle mass index SMI was not obvious, which showed the increase of grip strength and four meter pace, but the skeletal muscle mass index SMI had no significant change. The effect of MSTN, SOD, TNF- alpha in the serum index of aging muscle atrophy was obvious, and the effect on serum index IGF-1 was not obvious, which showed that the prognosis was MSTN, TNF- alpha index decreased, SOD index increased, but IGF-1 index had no significant change.
【學(xué)位授予單位】：武漢體育學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：G804.2

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