本文選題：有氧運(yùn)動(dòng) + 肥胖��； 參考：《武漢體育學(xué)院學(xué)報(bào)》2017年07期

【摘要】：目的:觀察有氧運(yùn)動(dòng)對(duì)大鼠肝臟功能以及CYP7A1mRNA的表達(dá)。方法:對(duì)高脂飲食飼養(yǎng)的肥胖及肥胖抵抗大鼠進(jìn)行8周的運(yùn)動(dòng)干預(yù),用組織學(xué)染色及血清生化檢測(cè),評(píng)價(jià)大鼠肝臟脂代謝及功能;用相對(duì)定量PCR評(píng)價(jià)CYP7A1mRNA的表達(dá)情況。結(jié)果:肥胖對(duì)照組大鼠HE染色肝細(xì)胞胞質(zhì)內(nèi)顯現(xiàn)大小不等空泡,肝竇間隙明顯變窄,肥胖游泳組肝細(xì)胞形態(tài)基本正常,細(xì)胞核居中,肝細(xì)胞脂肪變性明顯減輕,肝竇間隙無(wú)明顯變化;肥胖對(duì)照組、肥胖抵抗對(duì)照組大鼠血清ALT、AST水平高于普飼對(duì)照組并且具有非常顯著的差異,肥胖游泳組大鼠血清ALT、AST顯著低于肥胖對(duì)照組;肥胖對(duì)照組大鼠CYP7A1mRNA相對(duì)表達(dá)量高度顯著低于普飼對(duì)照組。肥胖游泳組大鼠CYP7A1mRNA相對(duì)表達(dá)量顯著高于肥胖對(duì)照組。結(jié)論:10周高脂飲食可引肥胖及肥胖抵抗大鼠血脂出現(xiàn)異常,脂質(zhì)代謝紊亂、肝臟出現(xiàn)脂肪沉積、肝功能異常;有氧運(yùn)動(dòng)可能通過(guò)增加肥胖大鼠肝臟CYP7A1表達(dá),改善膽固醇轉(zhuǎn)化障礙,從而達(dá)到改善10周高脂飲食導(dǎo)致的肝功能異常的現(xiàn)象。
[Abstract]:Objective: to observe the effect of aerobic exercise on liver function and CYP7A1mRNA expression in rats. Methods: eight weeks exercise intervention was performed on obese and obese resistant rats fed with high fat diet. The liver lipid metabolism and function were evaluated by histological staining and serum biochemical test, and the expression of CYP7A1mRNA was evaluated by relative quantitative PCR. Results: in the obese control group, different vacuoles appeared in the cytoplasm of hepatocytes stained with HE, and the hepatic sinusoidal space was narrowed obviously. In the obese swimming group, the hepatocyte morphology was normal, the nucleus was in the middle, and the steatosis of the hepatocytes was alleviated. There was no significant change in the hepatic sinusoidal space, the serum alt AST level in obese control group and obese resistance control group was higher than that in general feeding control group and there was a significant difference, and the serum alt level in obese swimming group was significantly lower than that in obese control group. The relative expression of CYP7A1mRNA in obese control group was significantly lower than that in general feeding control group. The relative expression of CYP7A1mRNA in obese swimming group was significantly higher than that in obese control group. Conclusion 10 weeks of high fat diet can induce abnormal blood lipids, abnormal lipid metabolism, fat deposition and abnormal liver function in obese and obese resistant rats, aerobic exercise may increase the expression of CYP7A1 in the liver of obese rats. Improve cholesterol conversion disorder to improve liver dysfunction caused by 10-week high-fat diet.
【作者單位】： 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬武漢兒童醫(yī)院康復(fù)醫(yī)學(xué)科;江西省體育科學(xué)研究所;武漢體育學(xué)院健康科學(xué)學(xué)院;
【基金】：國(guó)家體育總局科研課題(2015B089) 霍英東教育基金會(huì)青年教師基金基礎(chǔ)性研究課題(121103)
【分類(lèi)號(hào)】：G804.2

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本文編號(hào)：1824108