【摘要】：目的應(yīng)用靜息態(tài)功能磁共振成像(rs-f MRI)探討難治性癲癇患者楔前葉與全腦功能連接的改變及其意義。方法對(duì)23例難治性癲癇患者(癲癇組)及23名健康人(對(duì)照組)進(jìn)行rs-f MRI檢查,采集數(shù)據(jù)后采用功能連接的方法,分別計(jì)算以左側(cè)楔前葉和右側(cè)楔前葉為感興趣區(qū)與全腦的功能連接,運(yùn)用雙樣本t檢驗(yàn)的統(tǒng)計(jì)學(xué)方法發(fā)現(xiàn)兩組的顯著性差異并進(jìn)行分析。結(jié)果癲癇組左側(cè)楔前葉與雙側(cè)頂下小葉、雙側(cè)島葉、右側(cè)緣上回、右側(cè)額中回和雙側(cè)額下回的功能連接較對(duì)照組減弱(均P0.05);癲癇組左側(cè)楔前葉與雙側(cè)海馬旁回、雙側(cè)額上回、左側(cè)后扣帶回的功能連接較對(duì)照組增強(qiáng)(均P0.05)。癲癇組右側(cè)楔前葉與左側(cè)頂下小葉、右側(cè)緣上回、右側(cè)額中回、右側(cè)額下回的功能連接較對(duì)照組減弱(均P0.05);癲癇組右側(cè)楔前葉與雙側(cè)楔葉、左側(cè)后扣帶回的功能連接較對(duì)照組增強(qiáng)(均P0.05)。結(jié)論難治性癲癇患者靜息狀態(tài)下楔前葉與全腦的功能連接存在異常,"默認(rèn)網(wǎng)絡(luò)"功能的抑制可能是癲癇患者意識(shí)及認(rèn)知等功能損害的重要原因。
[Abstract]:Objective to investigate the changes and significance of the connection between the anterior cuneiform lobe and the whole brain in patients with refractory epilepsy by resting functional magnetic resonance imaging (rs-f MRI). Methods rs-f MRI was performed in 23 patients with refractory seizures (epileptic group) and 23 healthy subjects (control group). After collecting the data, the functional connections between the left anterior cuneiform lobe and the right anterior cuneiform lobe as the region of interest and the whole brain were calculated by means of functional connection. The significant difference between the two groups was found by double sample t test. Results the functional connections between the left anterior cuneiform lobe and bilateral inferior parietal lobe, bilateral insular lobe, right superior marginal gyrus, right middle frontalis and bilateral inferior frontalis gyrus were weaker than those in the control group (all P 0.05), and the functional connections between the left anterior cuneiform lobe and bilateral suprahippocampal gyrus, bilateral superior frontalis and left posterior cingulate gyrus in the epileptic group were stronger than those in the control group (P 0.05). The functional connections between the right anterior cuneiform lobe and the left inferior parietal lobe, the right superior marginal gyrus, the right middle frontalis gyrus and the right inferior frontal gyrus in the epileptic group were weaker than those in the control group (P 0.05), and the functional connections between the right anterior cuneiform lobe and bilateral cuneiform lobe and the left posterior cingulate gyrus in the epileptic group were stronger than those in the control group (P 0.05). Conclusion the functional connection between the anterior cuneiform lobe and the whole brain is abnormal in the resting state of refractory epileptic patients. The inhibition of "default network" function may be an important reason for the impairment of consciousness and cognition in epileptic patients.
【作者單位】： 安徽醫(yī)科大學(xué)附屬省立醫(yī)院神經(jīng)外科腦功能與腦疾病安徽省重點(diǎn)實(shí)驗(yàn)室;安徽醫(yī)科大學(xué)第三附屬醫(yī)院合肥市濱湖醫(yī)院神經(jīng)外科;
【基金】：國(guó)家自然科學(xué)基金(30973084) 安徽省自然科學(xué)基金(11040606M167) 安徽省科技攻關(guān)計(jì)劃項(xiàng)目(1301042201) 安徽省重點(diǎn)實(shí)驗(yàn)室績(jī)效考核項(xiàng)目(1306c083028)
【分類(lèi)號(hào)】：R445.2;R742.1

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