【摘要】：目的探討ICU耐美羅培南銅綠假單胞菌感染的危險因素,以期采取最佳治療對策控制感染。方法選擇2011年5月-2013年6月醫(yī)院感染耐美羅培南銅綠假單胞菌35例患者為研究對象,作為研究組,選取同期未感染耐美羅培南銅綠假單胞菌36例患者作為對照組,采用多因素分析感染的相關(guān)危險因素,對比治療前后研究組在白細(xì)胞計數(shù)、中性粒細(xì)胞百分比、體溫、C-反應(yīng)蛋白等炎癥指標(biāo)的變化情況;使用SPSS16.0軟件對數(shù)據(jù)進(jìn)行統(tǒng)計分析。結(jié)果機(jī)械通氣時間1周、入住ICU時間1周、經(jīng)驗性使用碳青霉烯類抗菌藥物是ICU住院患者感染耐美羅培南銅綠假單胞菌的相關(guān)危險因素(P0.05);而機(jī)械通氣時間、入住ICU時間、經(jīng)驗性使用碳青霉烯類抗菌藥物是ICU感染耐美羅培南銅綠假單胞菌獨(dú)立危險因素(P0.01);研究組患者治療前白細(xì)胞、中性粒細(xì)胞、體溫、C-反應(yīng)蛋白分別為(14.73±5.62)×109/L、(81.42±5.68)%、(39.11±0.34)℃、(67.35±36.36)mg/L,治療后分別為(7.83±1.23)×109/L、(58.95±4.23)%、(36.72±0.25)℃、(6.78±3.56)mg/L,治療前后比較差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論早期細(xì)菌學(xué)檢查確診致病菌,減少經(jīng)驗性碳青霉烯類抗菌藥物使用,加強(qiáng)ICU消毒隔離措施,減少機(jī)械通氣時間,可有效降低ICU耐美羅培南銅綠假單胞菌感染。
[Abstract]:Objective to investigate the risk factors of ICU-resistant Pseudomonas aeruginosa infection in order to control the infection. Methods from May 2011 to June 2013, 35 patients with pseudomonas aeruginosa resistant to meropenem were selected as the study group and 36 patients with pseudomonas aeruginosa resistant to meropenem as the control group. The risk factors of infection were analyzed by multivariate analysis, and the changes of leukocyte count, percentage of neutrophils, body temperature and C-reactive protein were compared before and after treatment in the study group. Use SPSS16.0 software to carry on the statistical analysis to the data. Results the time of mechanical ventilation was 1 week, the time of staying in ICU was 1 week. The empirical use of carbapenem antibiotics was the risk factor of infection of Pseudomonas aeruginosa resistant to meropenem in ICU inpatients (P0.05). The time of mechanical ventilation, the time of staying in ICU, the empirical use of carbapenem antibiotics were the independent risk factors of ICU infection with meropenem resistant Pseudomonas aeruginosa (P0.01). Before treatment, leukocytes, neutrophils, body temperature and C-reactive protein were (14.73 鹵5.62) 脳 10 ~ 9 / L, (81.42 鹵5.68)%, (39.11 鹵0.34) 鈩，

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