【摘要】：目的探討血清白細(xì)胞介素-8(IL-8)與C-反應(yīng)蛋白(CRP)測定對新生兒細(xì)菌感染診治效果,從而提高新生兒細(xì)菌感染檢測和治療的科學(xué)性。方法選擇2013年6月-2014年11月醫(yī)院出生的100例新生兒為研究對象,將臨床確診細(xì)菌感染新生兒52例為觀察組,臨床疑似細(xì)菌感染新生兒48例為對照組;對兩組新生兒進(jìn)行血常規(guī)、血培養(yǎng)和IL-8+CRP檢測,并對其給予抗菌藥物臨床治療,視實際病情待新生兒痊愈后再次進(jìn)行上述指標(biāo)檢測,觀察兩組新生兒檢測指標(biāo)陰性與陽性例數(shù)和IL-8聯(lián)合CRP預(yù)測新生兒感染情況,并比較新生兒治療前后IL-8、CRP水平差異;采用SPSS13.0軟件對數(shù)據(jù)進(jìn)行統(tǒng)計分析。結(jié)果觀察組在血常規(guī)、血培養(yǎng)和IL-8+CRP檢測陽性例數(shù)均高于對照組,其中IL-8+CRP檢測陽性例數(shù)最多,高于對照組26例,差異有統(tǒng)計學(xué)意義(P0.05);發(fā)現(xiàn)采用IL-8聯(lián)合CRP預(yù)測新生兒感染陰性預(yù)測率為98.93%,預(yù)測率明顯高于單一采用IL-8或CRP,差異有統(tǒng)計學(xué)意義(P0.05);兩組新生兒治療后IL-8、CRP水平較治療前均明顯下降,降為正常水平,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論綜合運用血清IL-8聯(lián)合CRP測定在新生兒細(xì)菌感染檢測中能夠提高檢測準(zhǔn)確度和精度,避免誤診、漏診,且抗菌藥物使用以IL-8≥80ng/L或CRP≥10mg/L臨界值最佳。
[Abstract]:Objective to investigate the effect of serum interleukin-8 (IL-8) and C-reactive protein (CRP) in the diagnosis and treatment of neonatal bacterial infection, so as to improve the scientific nature of the detection and treatment of neonatal bacterial infection. Methods 100 newborns born in hospital from June 2013 to November 2014 were selected as study objects. 52 newborns with clinically confirmed bacterial infection were selected as observation group and 48 neonates with suspected bacterial infection as control group. Blood routine test, blood culture and IL-8 CRP test were carried out in the two groups of newborns, and they were treated with antimicrobial drugs, and the above indexes were tested again after the newborns were cured according to the actual condition. The neonatal infection was predicted by IL-8 combined with CRP, and the difference of IL-8,CRP level before and after treatment was compared between the two groups. The data were analyzed by SPSS13.0 software. Results the positive cases of blood routine, blood culture and IL-8 CRP detection in the observation group were higher than those in the control group, among which the IL-8 CRP positive cases were the most, higher than the control group in 26 cases, the difference was statistically significant (P0.05). It was found that the negative predictive rate of neonatal infection using IL-8 combined with CRP was 98.93, and the predictive rate was significantly higher than that using IL-8 or CRP, alone (P0.05). The level of IL-8,CRP in the two groups after treatment was significantly lower than that before treatment, and decreased to the normal level, the difference was statistically significant (P0.05). Conclusion the combined use of serum IL-8 and CRP in the detection of neonatal bacterial infection can improve the accuracy and accuracy of detection, avoid misdiagnosis and missed diagnosis, and the critical value of IL-8 鈮，

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