貴州省甕安縣2015年孕婦麻疹、風(fēng)疹和流行性腦脊髓膜炎抗體水平監(jiān)測(cè)分析
發(fā)布時(shí)間：2018-11-21 09:32
【摘要】：目的了解孕婦麻疹、風(fēng)疹、流行性腦脊髓膜炎(流腦)免疫水平,探討成人及8月齡兒童上述疾病的發(fā)病原因,為制定疫苗針對(duì)性傳染病防制策略提供依據(jù)。方法收集368份甕安縣孕婦血清標(biāo)本,用酶聯(lián)免疫吸附試驗(yàn)(ELISA)檢測(cè)麻疹、風(fēng)疹、流腦IgG抗體。結(jié)果在368份孕婦血清標(biāo)本中,麻疹、風(fēng)疹、A群流腦和C群流腦IgG抗體陽性率分別為82.88%、89.4%、92.12%和23.10%,抗體幾何平均濃度(GMC)分別為535.67 m IU/ml,51.19 IU/ml,5.56μg/ml和1.07μg/ml。結(jié)論甕安縣孕婦麻疹和風(fēng)疹I(lǐng)gG抗體水平稍低,建議育齡婦女孕前接種含麻疹和風(fēng)疹成分疫苗以有效控制小月齡兒童麻疹、風(fēng)疹發(fā)病,預(yù)防先天性風(fēng)疹綜合征(CRS);孕婦對(duì)C群流腦的免疫力差,可能會(huì)出現(xiàn)C群流腦感染,建議育齡婦女孕前接種C群腦膜炎球菌疫苗,減少其感染風(fēng)險(xiǎn)。
[Abstract]:Objective to investigate the immunological level of measles, rubella and epidemic cerebrospinal meningitis (meningitis) in pregnant women, and to explore the causes of these diseases in adults and children at 8 months of age, so as to provide evidence for the prevention and control of vaccine-specific infectious diseases. Methods 368 serum samples of pregnant women in Weng'an County were collected. The antibodies against measles, rubella and IgG were detected by enzyme linked immunosorbent assay (ELISA). Results the positive rates of IgG antibodies against measles, rubella, group A and group C in 368 pregnant women were 82.88% and 89.4%, respectively, and 23.10%, respectively. The geometric mean concentration (GMC) of antibody was 535.67 m IU/ml,51.19 IU/ml,5.56 渭 g/ml and 1.07 渭 g / ml, respectively. Conclusion the level of IgG antibody to measles and rubella in pregnant women in Weng'an County is slightly lower. It is suggested that pregnant women of childbearing age should be vaccinated with measles and rubella components before pregnancy in order to effectively control measles and rubella in young children and prevent (CRS); from congenital rubella syndrome. In order to reduce the risk of group C meningococcal infection, it is suggested that pregnant women should be vaccinated with group C meningococcal vaccine before pregnancy.
【作者單位】： 貴州省疾病預(yù)防控制中心;甕安縣婦幼保健院;貴陽市疾病預(yù)防控制中心;
【基金】：貴州省衛(wèi)生廳科學(xué)技術(shù)基金資金資助項(xiàng)目(gzwkj2013-1-083) 貴州省傳染病預(yù)防與控制人才基地資金資助(RC3D1402)
【分類號(hào)】：R446.6
本文編號(hào)：2346571
[Abstract]:Objective to investigate the immunological level of measles, rubella and epidemic cerebrospinal meningitis (meningitis) in pregnant women, and to explore the causes of these diseases in adults and children at 8 months of age, so as to provide evidence for the prevention and control of vaccine-specific infectious diseases. Methods 368 serum samples of pregnant women in Weng'an County were collected. The antibodies against measles, rubella and IgG were detected by enzyme linked immunosorbent assay (ELISA). Results the positive rates of IgG antibodies against measles, rubella, group A and group C in 368 pregnant women were 82.88% and 89.4%, respectively, and 23.10%, respectively. The geometric mean concentration (GMC) of antibody was 535.67 m IU/ml,51.19 IU/ml,5.56 渭 g/ml and 1.07 渭 g / ml, respectively. Conclusion the level of IgG antibody to measles and rubella in pregnant women in Weng'an County is slightly lower. It is suggested that pregnant women of childbearing age should be vaccinated with measles and rubella components before pregnancy in order to effectively control measles and rubella in young children and prevent (CRS); from congenital rubella syndrome. In order to reduce the risk of group C meningococcal infection, it is suggested that pregnant women should be vaccinated with group C meningococcal vaccine before pregnancy.
【作者單位】： 貴州省疾病預(yù)防控制中心;甕安縣婦幼保健院;貴陽市疾病預(yù)防控制中心;
【基金】：貴州省衛(wèi)生廳科學(xué)技術(shù)基金資金資助項(xiàng)目(gzwkj2013-1-083) 貴州省傳染病預(yù)防與控制人才基地資金資助(RC3D1402)
【分類號(hào)】：R446.6
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