【摘要】：Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers.Saliva, as a non-invasive and safe source, could be a substitute for blood in the diagnosis and prognosis of diseases. This review summarizes the latest advancements in saliva-related studies and addresses the potential value of saliva in the early diagnosis of oral diseases, such as dental caries and periodontal disease, as well as cancer, diabetes and other systemic disorders. Saliva biomarkers range from changes in the biochemical indices of DNA, RNA and proteins to the diversi?cation of microbiota structures. This study integrates data reported in the recent literature and discusses the clinical signi?cance and prospects for the application of saliva in the early diagnosis of diseases, translational medicine and precision medicine.
[Abstract]:Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers.Saliva, as a non-invasive and safe source, could be a substitute for blood in the diagnosis and prognosis of diseases. This review summarizes the latest advancements in saliva-related studies and addresses the potential value of saliva in the early diagnosis of oral diseases, such as dental caries and periodontal disease, as well as cancer, diabetes and other systemic disorders. Saliva biomarkers range from changes in the biochemical indices of DNA, RNA and proteins to the diversi?cation of microbiota structures. This study integrates data reported in the recent literature and discusses the clinical signi?cance and prospects for the application of saliva in the early diagnosis of diseases, translational medicine and precision medicine.
【作者單位】： State
【基金】：supported by the National Natural Science Foundation of China (81430011 to Xue-Dong Zhou and 81371135 to Ji-Yao Li) Clinical Advanced Technique Award of West China Hospital of Stomatology (LCXJS2015 to Xin Xu) the Brilliant Young Investigator Award,Sichuan University (2015SCU04A16 to Xin Xu)
【分類(lèi)號(hào)】：R446.1

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