151例淋巴瘤外周血造血干細(xì)胞采集影響因素分析
[Abstract]:Objective: to analyze the influence of various factors on the collection of peripheral blood stem cells in patients with lymphoma, in order to improve the efficiency of stem cell collection. Methods: the effects of various factors on the number of hematopoietic stem cells collected from 151 patients with lymphoma were analyzed retrospectively. These factors included age, sex, height, weight, pathological type, staging, mobilization program, days of collection, transfusion of blood products, duration of course of disease and the course of chemotherapy. Results: univariate analysis showed that sex, height, weight, pathological type, stage, mobilization program, collecting days, There was no significant correlation between the amount of CD34 ~ cells collected and the age (r ~ (-0.248) P ~ (0.002). After the age of 50 years old, the collection of CD34 ~ cells decreased significantly, and that of CD34~ cells more than 60 years old decreased significantly. The duration of disease and the number of chemotherapeutic courses before mobilization had a significant effect on the collection of CD34~ cells. There was no significant correlation between the amount of CD34~ cells collected and the WBC (rn 0.053) in the blood routine index before collection, but there was a significant correlation with the percentage of mononuclear cells (r = 0.260) and the absolute value of mononuclear cells (r = 0.338P0. 00003). Conclusion under 60 years old, the chemotherapy course before mobilization is less, the number of mononuclear cells after mobilization is (2-6) 脳 10 ~ 9 / L patients may have higher peripheral blood stem cell collection.
【作者單位】: 北京大學(xué)腫瘤醫(yī)院暨北京市腫瘤防治研究所輸血科惡性腫瘤發(fā)病機(jī)制及轉(zhuǎn)化研究教育部重點(diǎn)實(shí)驗(yàn)室;
【分類號(hào)】:R457.7;R733.1
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