本文選題：高強度聚焦超聲 + 焦域　； 參考：《應(yīng)用聲學(xué)》2016年04期

【摘要】：為了研究腦組織和腦腫瘤組織在HIFU治療時形成焦域的特性及壞死腫瘤組織、不同治療劑量參數(shù)以及多次治療時焦點間距和時間間隔對HIFU形成焦域的影響,本文以腦膠質(zhì)瘤患者為例,利用患者頭顱CT圖像數(shù)據(jù)建立HIFU經(jīng)顱治療的仿真模型,基于Westervelt聲波非線性傳播方程和Pennes生物熱傳導(dǎo)方程進行HIFU經(jīng)顱治療的仿真研究。結(jié)果表明,腦組織和腦腫瘤組織內(nèi)形成HIFU焦域的差異較小,壞死腫瘤組織對HIFU溫度場分布有較小影響;輻照聲強越大,焦點溫升達到同一溫度所用時間越短,焦域長短軸越短,顱骨處溫升越低;當(dāng)焦點間距在一定范圍內(nèi)時,第一次輻照形成的溫度場分布對第二個焦點溫升達到同一溫度所需時間影響較大;兩次輻照時間間隔對顱骨處溫升和兩次聚焦形成60?C以上溫度分布影響較小。
[Abstract]:In order to study the characteristics of focal area formation in brain tissue and brain tumor tissue during HIFU treatment, the effects of different dosage parameters, focal distance and time interval on focal area formation in HIFU were studied. In this paper, a simulation model of HIFU transcranial therapy was established by using CT images of brain gliomas as an example. The simulation study of HIFU transcranial therapy was carried out based on Westervelt acoustic wave nonlinear propagation equation and Pennes biothermic conduction equation. The results showed that there was little difference in the formation of HIFU focal region between brain tissue and brain tumor tissue, and the necrotic tumor tissue had a little effect on the distribution of HIFU temperature field, and the larger the radiation intensity, the shorter the time of focal temperature rise to the same temperature, and the shorter the long and long axis of focal region. When the focal distance is within a certain range, the distribution of the temperature field formed by the first irradiation has a great influence on the time required for the second focal point to reach the same temperature. The effect of the interval of two irradiation time on the temperature rise of skull and the temperature distribution above 60 鈩，

本文編號：1893434