本文關鍵詞：遺傳因素在風險決策加工中的作用，，由筆耕文化傳播整理發(fā)布。

第2期何清華等:遺傳因素在風險決策加工中的作用2；Psychiatry,62(2),146–152；Hariri,A.R.,&Holmes,；He,Q.,Xue,G.,Chen,C.,Lu,；He,Q.,Xue,G.,Chen,C.,Lu,；Homberg,J.R.,vandenBos,R；Hu,X.-Z.,Lipsky,R.H.,Zhu；Johns

第2期 何清華等: 遺傳因素在風險決策加工中的作用 201

Psychiatry, 62(2), 146–152.

Hariri, A. R., & Holmes, A. (2006). Genetics of emotional regulation: The role of the serotonin transporter in neural function. Trends in Cognitive Sciences, 10(4), 182–191. Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., … Weinberger, D. R. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297(5580), 400–403. Hariri, A. R., Tessitore, A., Mattay, V. S., Fera, F., & Weinberger, D. R. (2002). The amygdala response to emotional stimuli: A comparison of faces and scenes. Neuroimage, 17(1), 317–323.

He, Q., Xue, G., Chen, C., Lu, Z., Dong, Q., Lei, X., … Bechara, A. (2010). Serotonin transporter gene-linked polymorphic region (5-HTTLPR) influences decision making under ambiguity and risk in a large Chinese sample. Neuropharmacology, 59(6), 518–526.

He, Q., Xue, G., Chen, C., Lu, Z. L., Lei, X., Liu, Y., … Bechara, A. (2012). COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making. Scientific Reports, (2), 677. Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., … Büchel, C. (2005). Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience, 8(1), 20–21.

Homberg, J. R., van den Bos, R., den Heijer, E., Suer, R., & Cuppen, E. (2008). Serotonin transporter dosage modulates long-term decision-making in rat and human. Neuropharmacology, 55(1), 80–84.

Hu, X.-Z., Lipsky, R. H., Zhu, G., Akhtar, L. A., Taubman, J., Greenberg, B. D., … Goldman, D. (2006). Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. The American Journal of Human Genetics, 78(5), 815–826.

Johns, L. C., Cannon, M., Singleton, N., Murray, R. M., Farrell, M., Brugha, T., … Meltzer, H. (2004). Prevalence and correlates of self-reported psychotic symptoms in the British population. The British Journal of Psychiatry, 185(4), 298–305.

F., Leboyer, M., … Courtet, P. (2007). The influence of four serotonin-related genes on decision-making in suicide attempters. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B (5), 615–624.

Kang, J. I., Namkoong, K., Ha, R. Y., Jhung, K., Kim, Y. T., & Kim, S. J. (2010). Influence of BDNF and COMT polymorphisms on emotional decision making. Neuropharmacology, 58(7), 1109–1113.

Kuhnen, C. M., & Chiao, J. Y. (2009). Genetic determinants of financial risk taking. PLoS One, 4(2), e4362.

Chen, C., Chen, C., Moyzis, R., Stern, H., He, Q., Li, H., … Dong, Q. (2011). Contributions of dopamine-related genes and environmental factors to highly sensitive personality: A Multi-Step neuronal System-Level approach. PLoS One, 6(7), e21636.

Chen, C., Chen, C., Moyzis, R. K., Dong, Q., He, Q., Li, H., … Dong, Q. (2012). Genetic variations in the dopaminergic system and Alcohol use: A System-Level analysis. Addiction Biology, 17(2), 478–489.

Chen, C., Chen, W., Chen, C., Moyzis, R., He, Q., Lei, X., … Dong, Q. (2013). Genetic variations in the serotoninergic system contribute to Body-Mass index in Chinese adolescents. PLoS One, 8(3), e58717.

Chen, X., Liu, M., & Li, D. (2000). Parental warmth, control, and indulgence and their relations to adjustment in Chinese children: A longitudinal study. Journal of Family Psychology, 14(3), 401–419.

Crisan, L. G., Pana, S., Vulturar, R., Heilman, R. M., Szekely, R., Druga, B., …Miu, A. C. (2009). Genetic contributions of the serotonin transporter to social learning of fear and economic decision making. Social Cognitive and Affective Neuroscience, 4(4), 399–408.

Dreher, J. C., Kohn, P., Kolachana, B., Weinberger, D. R., & Berman, K. F. (2009). Variation in dopamine genes influences responsivity of the human reward system. Proceedings of the National Academy of Sciences of the United States of America, 106(2), 617–622.

Fabre, V., Beaufour, C., Evrard, A., Rioux, A., Hanoun, N., Lesch, K. P., …Martres, M. P. (2000). Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. European Journal of Neuroscience, 12(7), 2299–2310.

Gu, H., Liu, C., Chen, M., Zhang, Q., Zhai, J., Wang, K., … Chen, C. (2013). The combined effects of the 5-HTTLPR and HTR1A rs6295 polymorphisms modulate decision making in schizophrenia patients. Genes, Brain and Behavior, 12(1), 133–139.

Gupta, R., Duff, M. C., Denburg, N. L., Cohen, N. J., Bechara, A., & Tranel, D. (2009). Declarative memory is decision-making. Neuropsychologia, 47(7), 1686–1693. Ha, R. Y., Namkoong, K., Kang, J. I., Kim, Y. T., & Kim, S. J. (2009). Interaction between serotonin transporter promoter and dopamine receptor D4 polymorphisms on decision making. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(7), 1217–1222.

Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., & Weinberger, D. R. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General

critical for sustained advantageous complex Jollant, F., Buresi, C., Guillaume, S., Jaussent, I., Bellivier,

202 心 理 科 學 進 展 第22卷

Labus, J. S., Mayer, E. A., Hamaguchi, T., Mizuno, T., Kano, M., & Fukudo, S. (2008). 5-Httlpr gene polymorphism modulates activity and connectivity within an emotional arousal network of healthy control subjects during visceral pain. Gastroenterology, 134(4, Supplement 1), A-121. Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y. M., Szumlanski, C. L., & Weinshilboum, R. M. (1996). Human Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6(3), 243–250.

Li, Q., Wichems, C., Heils, A., Lesch, K.-P., & Murphy, D. L. (2000). Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: Gender and brain region differences. The Journal of Neuroscience, 20(21), 7888–7895.

Li, Q., Wichems, C., Heils, A., Van de Kar, L. D., Lesch, K.-P., & Murphy, D. L. (1999). Reduction of 5-hydroxytryptamine (5-HT) 1A-mediated temperature and neuroendocrine responses and 5-HT1A binding sites in 5-HT transporter knockout mice. Journal of Pharmacology and Experimental Therapeutics, 291(3), 999–1007.

Li, X., Lu, Z.-L., D'Argembeau, A., Ng, M., & Bechara, A. (2009). The lowa gambling task in fMRI images. Human Brain Mapping, 31(3), 410–423.

Maurex, L., Zaboli, G., Wiens, S., Asberg, M., Leopardi, R., & ?hman, A. (2009). Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder. Scandinavian Journal of Psychology, 50(1), 5–10. Mereu, G., Lilliu, V., Vargiu, P., Muntoni, A. L., Diana, M., & Gessa, G. L. (1995). Depolarization inactivation of dopamine neurons: An artifact? The Journal of Neuroscience, 15(2), 1144–1149.

Morsanyi, K., & Handley, S. J. (2008). How smart do you need to be to get it wrong? The role of cognitive capacity in the development of heuristic-based judgment. Journal of Experimental Child Psychology, 99(1), 18–36.

Munafo, M., R., Brown, S. M., & Hariri, A. R. (2008). Serotonin Transporter (5-HTTLPR) Genotype and Amygdala Activation: A Meta-Analysis. Biological Psychiatry, 63(9), 852–857.

Must, A., Juhász, A., Rimanóczy, A., Szabó, Z., Kéri, S., & Janka, Z. (2007). Major depressive disorder, serotonin transporter, and personality traits: Why patients use suboptimal decision-making strategies? Journal of Affective Disorders, 103(1-3), 273–276.

Overman, W., Graham, L., Redmond, A., Eubank, R.,

Boettcher, L., Samplawski, O., & Walsh, K. (2006). Contemplation of moral dilemmas eliminates sex differences on the Iowa Gambling Task. Behavioral Neuroscience, 120(4), 817–825.

Penington, N., Kelly, J., & Fox, A. (1993). Whole-cell recordings of inwardly rectifying K+ currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult Plomin, R., Haworth, C. M., & Davis, O. S. (2009). Common disorders are quantitative traits. Nature Reviews Genetics, 10(12), 872–878.

Reavis, R., & Overman, W. H. (2001). Adult sex differences on a decision-making task previously shown to depend on the orbital prefrontal cortex. Behavioral Neuroscience, 115(1), 196–206.

Roiser, J. P., de Martino, B., Tan, G. C., Kumaran, D., Seymour, B., Wood, N. W., & Dolan, R. J. (2009). A genetically mediated bias in decision making driven by failure of amygdala control. The Journal of Neuroscience, 29(18), 5985–5891.

Roussos, P., Giakoumaki, S. G., Pavlakis, S., & Bitsios, P. (2008). Planning, decision-making and the COMT rs4818 polymorphism in healthy males. Neuropsychologia, 46(2), 757–763.

Segal, N. L., & Hershberger, S. L. (1999). Cooperation and competition between twins: Findings from a prisoner's dilemma game. Evolution and Human Behavior, 20(1), 29–51.

Sinha, R. (2001). How does stress increase risk of drug abuse and relapse? Psychopharmacology, 158(4), 343–359. Sinha, R. (2008). Chronic stress, drug use, and vulnerability to addiction. Annals of the New York Academy of Sciences, 1141(1), 105–130.

Sinha, R., Catapano, D., & O’Malley, S. (1999). Stress-induced craving and stress response in cocaine dependent individuals. Psychopharmacology, 142(4), 343–351.

Slutske, W. S., Zhu, G., Meier, M. H., & Martin, N. G. (2010). Genetic and environmental influences on disordered gambling in men and women. Archives of General Psychiatry, 67(6), 624–630.

Starcke, K., & Brand, M. (2012). Decision making under stress: A selective review. Neuroscience & Biobehavioral Reviews, 36(4), 1228–1248.

Stoltenberg, S. F., Lehmann, M. K., Anderson, C., Nag, P., & Anagnopoulos, C. (2011). Serotonin transporter (5-HTTLPR) genotype and childhood trauma are associated with individual differences in decision making. Frontiers in Behavioral and Psychiatric Genetics, (2), 33. Stoltenberg, S. F., & Vandever, J. M. (2010). Gender moderates the association between 5-HTTLPR and

catechol-O-methyltransferase pharmacogenetics: rat. The Journal of Physiology, 469(1), 387–405.

第2期 何清華等: 遺傳因素在風險決策加工中的作用 203

of Psychiatry, 188(6), 519–526.

Xiao, L., Bechara, A., Palmer, P. H., Trinidad, D. R., Wei, Y., Jia, Y., & Johnson, C. A. (2011). Parent–child engagement in decision-making and the development of adolescent affective decision capacity and binge-drinking. Personality and Individual Differences, 51(3), 285–292. Xue, G., Chen, C., Lu, Z., & Dong, Q. (2010). Brain imaging techniques and their applications in decision-making research. Acta Psychologica Sinica, 42(1), 120–137. Yacubian, J., Sommer, T., Schroeder, K., Glascher, J., Kalisch, R., Leuenberger, B., … Büchel, C. (2007). Gene-gene interaction associated with neural reward sensitivity. Proceedings of the National Academy of Sciences of the United States of America, 104(19), 8125–8130.

Yechiam, E., & Busemeyer, J. (2005). On the examination of basic assumptions embedded in learning models. Journal of Mathematical Psychology, 49(1), 108.

Yechiam, E., Hayden, E. P., Bodkins, M., O'Donnell, B. F., & Hetrick, W. P. (2008). Decision making in bipolar disorder: A cognitive modeling approach. Psychiatry Research, 161(2), 142–152.

Zhong, S., Israel, S., Xue, H., Sham, P. C., Ebstein, R. P., & Chew, S. H. (2009). A neurochemical approach to valuation sensitivity over gains and losses. Proceedings of the Royal Society B: Biological Sciences, 276(1676), 4181–4188. Zhu, B., Chen, C., Moyzis, R. K., Dong, Q., He, Q., Stern, H., … Lin, C. (2012). Genetic variations in the dopamine system and facial expression recognition in healthy Chinese college students. Neuropsychobiology, 65(2), 83–89.

decision-making under ambiguity but not under risk. Neuropharmacology, 58(2), 423–428.

Tom, S. M., Fox, C. R., Trepel, C., & Poldrack, R. A. (2007). The neural basis of loss aversion in decision-making under risk. Science, 315(5811), 515-518.

Tuvblad, C., Gao, Y., Wang, P., Raine, A., Botwick, T., & Baker, L. A. (2012). The genetic and environmental etiology of decision-making: A longitudinal twin study. Journal of Adolescence, 36(2), 245–255.

van den Bos, R., Homberg, J., Gijsbers, E., den Heijer, E., & Cuppen, E. (2009). The effect of COMT Val158 Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females. Neuropharmacology, 56(2), 493–498.

Van Winkel, R., Stefanis, N. C., & Myin-Germeys, I. (2008). Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophrenia Bulletin, 34(6), 1095–1105. Wai, M. S., Shi, C., Kwong, W. H., Zhang, L., Lam, W. P., & Yew, D. T. (2008). Development of the human insular cortex: Differentiation, proliferation, cell death, and appearance of 5HT-2A receptors. Histochemistry and Cell Biology, 130(6), 1199–1204.

Wallace, B., Cesarini, D., Lichtenstein, P., & Johannesson, M. (2007). Heritability of ultimatum game responder behavior. Proceedings of the National Academy of Sciences of the United States of America, 104(40), 15631–15634.

Wiles, N. J., Zammit, S., Bebbington, P., Singleton, N., Meltzer, H., & Lewis, G. (2006). Self-reported psychotic symptoms in the general population. The British Journal

The Role of Genes in Risky Decision Making

HE Qinghua1; XUE Gui2; CHEN Chunhui2; DONG Qi2; CHEN Chuansheng3

(1 Faculty of Psychology, Southwest University, Chongqing 400715, China)

(2 National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China)

(3 University of California, Irvine, CA 92697, USA)

Abstract: Risky decision making is a complex process that involves weighing different options in terms of their likelihood of potential rewards and risks. It is one of the most important cognitive functions of the human brain. People differ significantly in their everyday risky decision making, partly influenced by genetic and environmental factors. In this article, we first review recent studies investigating the effect of genetic factors on risky decision making, including twin studies and molecular genetic studies. Candidate genes included dopamine-related genes (e.g., COMT and DAT), serotonin-related genes (e.g., SLC6A and TPH1), and other genes (e.g., BDNF). We then discussed the contribution of environment as well as gene-environment interaction to risky decision making. Recent studies have also incorporated brain anatomy and functions as endophenotypes of risky decision making in molecular genetic research. In the final section,

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we outline directions of future research that should emphasize gene-environment interactions and brain structure and functions as the mediators between genes and risky decision making.

Key words: heritability; genes; risky decision making; environment; gene-environment interaction; brain

通訊作者簡介：

陳傳升博士, 美籍華人, 美國加州大學爾灣分校心理與行為系、教育系、亞洲研究中心、認知神經(jīng)科學中心教授。1992年獲美國密歇根大學發(fā)展心理學博士學位。他的研究涉獵廣泛, 善于從多學科的角度研究文化、大腦、遺傳和認知之間的關系。他與第一作者何清華博士合作的研究主要采用基因技術和腦成像技術來考察風險決策的基因機制和神經(jīng)機制, 并試圖揭示那些具有風險決策障礙的相關精神疾病的發(fā)病機制。

Chuansheng Chen, Ph.D., Professor of Department of Psychology and Social Behavior, School of Education, Center for Asian studies, and Center of Cognitive Neuroscience at University of California, Irvine. He obtained his Ph.D. degree in developmental psychology from University of Michigan in 1992. He has diverse research interests and takes an interdisciplinary approach to studying the relationship between culture, brain, genes, and cognition. Collaborating with Dr. Qinghua He, the first author of this work, he used molecular genetic and neuroimaging techniques to investigate the genetic and neural bases of risky decision making, as well as the underlying mechanisms of psychiatric disorders with decision making deficits.

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