在本研究中,測(cè)定了香蘭醇在不同溶劑中的溶解度、介穩(wěn)區(qū),并對(duì)其結(jié)晶工藝進(jìn)行了優(yōu)化。在293.15K到343.15 K溫度范圍內(nèi),采用靜態(tài)法測(cè)定了香蘭醇在8種溶劑中的溶解度。發(fā)現(xiàn)香蘭醇的溶解度隨著溫度的升高而增大,在乙醇中溶解度最大,而在乙酸丁酯中最小。除此之外,采用改進(jìn)的Apelblat方程、λh方程和Wilson方程對(duì)香蘭醇的溶解度進(jìn)行擬合。基于Wilson方程和實(shí)驗(yàn)獲得的溶解度數(shù)據(jù)對(duì)香蘭醇在不同溶劑中的熱力學(xué)性質(zhì)進(jìn)行了研究。采用激光法測(cè)定了香蘭醇在乙醇、異丙醇和丙酮中的介穩(wěn)區(qū)寬度。發(fā)現(xiàn)介穩(wěn)區(qū)寬度受諸多因醇的影響,如冷卻速率、飽和溫度、攪拌速率等等。在這三種溶劑中的所有實(shí)驗(yàn),介穩(wěn)區(qū)的寬度都隨著飽和溫度的升高而變窄,隨降溫速率增大而變寬。并采用用三種經(jīng)典理論:Nyvlt理論,Nyvlt自締合理論和經(jīng)典3D成核理論研究香草醇的成核動(dòng)力學(xué)。然而,由于成核常數(shù)k值的物理意義在Nyvlt方法中不確定,所以Nyvlt自締合理論和3D經(jīng)典成核理論更適合。結(jié)果表明,香蘭醇在乙醇中成核是瞬時(shí)的,遵循多核（PN）機(jī)制,在異丙醇和丙酮中以high nucleation規(guī)則發(fā)生。最后,本文對(duì)香蘭醇的結(jié)晶工藝進(jìn)... 

【文章來源】：天津大學(xué)天津市 211工程院校 985工程院校 教育部直屬院校

【文章頁數(shù)】：73 頁

【學(xué)位級(jí)別】：碩士

【文章目錄】：
摘要
ABSTRACT
Chapter 1 Introduction
    1.1.Background
    1.2.Statement of Problem
    1.3.Objectives
Chapter 2 Solubility and Thermodynamic Properties of Vanillyl Alcohol in Different Solvents
    2.1.Introduction
    2.2.Experimental Section
        2.2.1.Materials
        2.2.2.Apparatus and Procedure
        2.2.3.Characterization
    2.3.Thermodynamic Models
        2.3.1.Modified Apelblat Equation
        2.3.2.λh Equation
        2.3.3.Local Composition Models
        2.3.4.Wilson Model
    2.4.Results and Discussion
        2.4.1.Identification and Characterization of Pure Chemicals
        2.4.2.Solubility of Vanillyl Alcohol
        2.4.3.Dissolution Thermodynamic Properties
    2.5.Conclusions
Chapter 3 Metastable Zone width Determination and Modelling
    3.1.Introduction
    3.2.Theory
        3.2.1.Nyvlt's Approach
        3.2.2.Self-Consistent Nyvlt-Like Approach
        3.2.3 Classical3D Nucleation Theory
    3.3.Experimental Section
        3.3.1.Materials
        3.3.2.Metastable Zone Width Measurements
    3.4.Results and Discussion
        3.4.1.Effect of Cooling Rate and Saturation Temperature on MSZW
    3.5.Conclusions
Chapter 4 Process Characterization and Optimization of Vanillyl Alcohol Crystallization
    4.1.Introduction
    4.2.Experimental Section
        4.2.1.Materials and Equipment's
        4.2.2.Experimental Procedure
    4.3.Results and Discussion
        4.3.1 Effect of Solvent
        4.3.2.Effect of Cooling Rate
        4.3.3.Effect of Agitation Speed
        4.3.4 Seeding Effect
    4.4.Conclusions
Chapter 5 Conclusions and Future Scopes
    1.Conclusions
    2.Future Scopes
References
Published Papers and Participated Scientific Research
ACKNOWLEDGEMENT



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