本文選題：噴霧流化床 + 造粒　； 參考：《東南大學(xué)》2017年碩士論文

【摘要】：噴霧流化床造粒在制藥、化工、食品等領(lǐng)域得到了廣泛應(yīng)用。流化造粒是氣固兩相流動、液體蒸發(fā)及結(jié)晶、顆粒涂布等的綜合過程,顆粒生長速率受到流化、干燥、物質(zhì)特性等多種因素的影響。在噴霧流化造粒過程中,組織良好的流化是必要條件,顆粒生長速率是描述造粒過程的核心參數(shù)。本文在噴霧流化床包衣實(shí)驗(yàn)臺上,考察流化失效和顆粒生長速率的相關(guān)規(guī)律。搭建了噴霧流化床造粒實(shí)驗(yàn)系統(tǒng),主要包括:流化床本體、噴霧系統(tǒng)、配氣系統(tǒng)、測量系統(tǒng)等。采用內(nèi)置中心筒和布風(fēng)板中心區(qū)域強(qiáng)化布風(fēng)的結(jié)構(gòu),組織顆粒在床內(nèi)的有序循環(huán);雙流體霧化噴嘴布置在中心筒內(nèi),由底向上噴霧,強(qiáng)化液滴與顆粒的接觸;通過預(yù)熱流化氣體控制物料干燥過程。通過噴水-停止噴水/加熱實(shí)驗(yàn),可以觀察到流化床從正常流化到流化失效,到再次恢復(fù)流化的過程。結(jié)果表明:增加噴液速率,流化失穩(wěn)速率增加;增加床料量和顆粒粒徑,流化失穩(wěn)速率減小。壓力波動方差可以有效反映床內(nèi)流化質(zhì)量,方差隨著流化失穩(wěn)而變大,隨流化恢復(fù)而變小。提高進(jìn)風(fēng)溫度、噴霧壓力,減小液體粘度,可以抑制流化失效的發(fā)生。床內(nèi)液固比是決定流化質(zhì)量的重要因素,控制床內(nèi)液固比有助于維持包衣過程的平穩(wěn)進(jìn)行。在噴霧流化造粒實(shí)驗(yàn)中,采用染色料液定性揭示了顆粒包衣過程,隨包衣過程的進(jìn)行,料液附著顆粒程度逐漸增加,顆粒顏色不斷加深。本文實(shí)驗(yàn)中,顆粒生長方式屬于層式生長方式,顆粒增重隨時(shí)間近似線性增加。進(jìn)一步,詳細(xì)比較了顆粒直徑、流化風(fēng)速、料液噴入速率、粘結(jié)劑濃度對顆粒增重率及生長速率的影響。發(fā)現(xiàn)提高料液噴入速率,顆粒生長速率明顯提高。流化風(fēng)速過小或過大均不利于顆粒包衣。床料粒徑較小時(shí),顆粒更易形成團(tuán)聚。增加粘結(jié)劑濃度,顆粒生長速率增加。
[Abstract]:Spray fluidized bed granulation has been widely used in pharmaceutical, chemical, food and other fields. Fluidized granulation is a comprehensive process of gas-solid two-phase flow, liquid evaporation and crystallization, and particle coating. The particle growth rate is affected by fluidization, drying and material properties. In the process of spray fluidization is a necessary condition and particle growth rate is the core parameter to describe the granulation process. In this paper, the correlation between fluidization failure and particle growth rate was investigated on a spray fluidized bed coating test bench. A spray fluidized bed granulation experiment system was built, including fluidized bed body, spray system, gas distribution system, measurement system and so on. The inner central cylinder and the central area of the air distribution plate are used to strengthen the air distribution structure, and the ordered circulation of the particles in the bed is organized, and the two-fluid atomizing nozzle is arranged in the center cylinder and sprayed from the bottom up to strengthen the contact between the droplets and the particles. The drying process is controlled by preheating fluidized gas. The fluidized bed can be observed from normal fluidization to fluidization failure and to restarting fluidization through water-spraying-stopping water spray / heating experiment. The results show that the rate of fluidization instability increases with the increase of injection rate, and decreases with the increase of bed material and particle size. The variance of pressure fluctuation can effectively reflect the fluidization quality in bed. The variance increases with the fluidization instability and decreases with the fluidization recovery. Increasing inlet air temperature, spray pressure and reducing liquid viscosity can inhibit fluidization failure. The liquid-solid ratio in the bed is an important factor to determine the fluidization quality, and controlling the liquid-solid ratio in the bed is helpful to maintain the smooth process of coating. In the spray fluidized granulation experiment, the particle coating process was revealed qualitatively by dyeing liquid. With the coating process, the adhesion degree and color of particles increased gradually. In this paper, the particle growth mode belongs to the laminar growth mode, and the particle weight increases linearly with time. Furthermore, the effects of particle diameter, fluidization velocity, feed injection rate and binder concentration on particle weight gain and growth rate were compared in detail. It was found that the particle growth rate increased obviously when the injection rate was increased. Too small or too large fluidized wind speed is not conducive to particle coating. When the particle size of bed material is small, it is easier to form agglomeration. The particle growth rate increased with the increase of binder concentration.
【學(xué)位授予單位】：東南大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：TQ021

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本文編號：1871130