【摘要】： 對涉嫌吸毒人員體液中濫用藥物進行可靠的分析是禁毒工作中的關(guān)鍵步驟,為公安機關(guān)預(yù)防和打擊濫用藥物犯罪提供有力的證據(jù)。由于社會的發(fā)展和科學(xué)技術(shù)的進步,現(xiàn)代分析儀器的普及和發(fā)展,使分析方法的靈敏度和準(zhǔn)確度有了可靠保證。因此,分離方法的可靠性、兼容性、選擇性已成為制約分析化學(xué)發(fā)展的瓶頸因素。在對體液中濫用藥物分析過程中,由于基質(zhì)的復(fù)雜性,被分析物質(zhì)的不確定性、微量性,對分離方法的可靠性、兼容性、選擇性提出了更高的要求。因此好的分離方法是確保鑒定結(jié)論正確的必要條件之一。為了探索更加經(jīng)濟、高效、快速的提取方法,本研究應(yīng)用近年來出現(xiàn)的乳狀液膜,探索建立了適合提取尿液中常見濫用藥物的經(jīng)濟實用、對人體無害、對實驗室環(huán)境無污染、無需濃縮、可循環(huán)利用的液膜體系并建立了相應(yīng)的萃取分析方法。 本研究優(yōu)化制膜方法和萃取條件,應(yīng)用最佳萃取條件對尿液中添加的甲基苯丙胺(methamphetamine)、氯胺酮(Ketamine)和嗎啡(morphine)進行萃取檢驗。與高效毛細管電泳技術(shù)聯(lián)用,測得這種方法對甲基苯丙胺(MA)、氯胺酮(K)和嗎啡的回收率。 研究結(jié)果發(fā)現(xiàn),這種提取方法具有很強的提取凈化效果,并具有很好的富集效果,能夠?qū)δ蛞褐泻哿康募谆奖?MA)、氯胺酮和嗎啡進行提取。
[Abstract]:The reliable analysis of drug abuse in body fluid of suspected drug users is a key step in drug control work and provides strong evidence for public security organs to prevent and combat drug abuse crimes. With the development of society and the progress of science and technology and the popularization and development of modern analytical instruments, the sensitivity and accuracy of analytical methods are guaranteed reliably. Therefore, the reliability, compatibility and selectivity of separation methods have become the bottleneck factors restricting the development of analytical chemistry. In the process of drug abuse analysis in body fluid, due to the complexity of matrix, uncertainty and trace of substance being analyzed, higher requirements for reliability, compatibility and selectivity of separation methods are put forward. Therefore, a good separation method is one of the necessary conditions to ensure the correct conclusion of identification. In order to explore a more economical, efficient and rapid extraction method, this study applied the emulsion liquid membrane which appeared in recent years to explore the establishment of a suitable extraction of commonly abused drugs in urine, which is economical and practical, harmless to human body, and no pollution to the laboratory environment. The liquid membrane system can be reused without concentration and the extraction analysis method is established. In this study, the membrane preparation method and extraction conditions were optimized. The methamphetamine (methamphetamine), ketamine (Ketamine) and morphine (morphine) were extracted and determined by the optimum extraction conditions. The recoveries of methamphetamine (MA), ketamine (K) and morphine were determined by high performance capillary electrophoresis (HPCE). The results showed that this method had a strong purification effect and a good enrichment effect. It could extract trace methamphetamine (MA), ketamine and morphine from urine.
【學(xué)位授予單位】：東北師范大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：D919.2

【引證文獻】

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1 王軍;金佳佳;張小凡;童敏;周洋;;生物檢材中苯丙胺類興奮劑的提取[J];江蘇警官學(xué)院學(xué)報;2012年05期

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本文編號：2223506