本文選題：法醫(yī)病理學(xué) + 冠心病猝死��； 參考：《中國(guó)法醫(yī)學(xué)雜志》2009年02期

【摘要】：目的探討Toll樣受體4(TLR4)與冠狀動(dòng)脈粥樣硬化(AS)斑塊急性病變的關(guān)系。方法從本教研室2004～2007年尸檢檔案中挑選24例病例及其心臟標(biāo)本。分為實(shí)驗(yàn)組(有冠脈急性病變的SCD者)、對(duì)照組Ⅰ(無(wú)冠脈急性病變的SCD者)和對(duì)照組Ⅱ(冠脈無(wú)嚴(yán)重AS的暴力死者)等3組,每組8例。用免疫組化SABC法和圖像分析技術(shù)定量檢測(cè)TLR4在各組冠狀動(dòng)脈AS斑塊內(nèi)表達(dá)的平均光密度值(OD),所得數(shù)據(jù)用SPSS14.0統(tǒng)計(jì)學(xué)軟件進(jìn)行分析處理并比較各組間的差異。結(jié)果實(shí)驗(yàn)組冠狀動(dòng)脈AS斑塊中TLR4表達(dá)呈強(qiáng)陽(yáng)性,對(duì)照組Ⅰ呈相對(duì)較弱的陽(yáng)性表達(dá),而對(duì)照組Ⅱ冠狀動(dòng)脈壁及輕度增厚的內(nèi)膜處均未見(jiàn)陽(yáng)性表達(dá),其OD值(0.4662±0.0190)與兩個(gè)對(duì)照組(分別為0.3361±0.0165,0.2463±0.0190)相比,對(duì)照組Ⅰ與對(duì)照組Ⅱ相比,其差異均具有統(tǒng)計(jì)學(xué)意義(P0.01)。結(jié)論冠狀動(dòng)脈AS斑塊中TLR4的表達(dá)情況可視作為冠狀動(dòng)脈AS斑塊發(fā)生急性病變的一個(gè)病理診斷指標(biāo),也是診斷冠心病猝死的重要依據(jù)之一。
[Abstract]:Objective to investigate the relationship between Toll like receptor 4 (TLR 4) and acute lesion of coronary atherosclerotic plaques.Methods 24 cases and their heart specimens were selected from the autopsy files of our department from 2004 to 2007.The patients were divided into three groups: experimental group (SCD with acute coronary artery disease), control group 鈪，

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