本文關(guān)鍵詞：液質(zhì)聯(lián)用技術(shù)在丹參成分分析中的應(yīng)用，由筆耕文化傳播整理發(fā)布。

液質(zhì)聯(lián)用技術(shù)在丹參成分分析中的應(yīng)用

Application of liquid chromatography coupled with mass spectrometry technique in component analysis of Salvia miltiorrhiza

[1] [2] [3] [4] [5] [6]

WANG Yang,CHEN Tao,PAN Lin,LI Zheng,CUI Wei-li,LI Jin（1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2. Tianj in First

[1]天津中醫(yī)藥大學(xué)第一附屬醫(yī)院,天津300193; [2]天津第一中心醫(yī)院,天津300192

文章摘要：丹參在中醫(yī)臨床中的應(yīng)用歷史悠久,其治療作用廣泛,特別是在治療心血管疾病時(shí)具有獨(dú)特的療效。丹酚酸及丹參酮類成分是丹參中的主要藥效成分,因其顯著的生物活性備受關(guān)注。液質(zhì)聯(lián)用技術(shù)（LC-MS）是集分離與分析于一體的具有快速、高靈敏度特點(diǎn)的綜合分析方法,現(xiàn)已廣泛用于中藥成分分析中。通過對(duì)國(guó)內(nèi)外文獻(xiàn)進(jìn)行系統(tǒng)整理,對(duì)LC-MS技術(shù)在丹參有效成分分析中的應(yīng)用進(jìn)行總結(jié),以期為科學(xué)闡釋丹參藥效物質(zhì)基礎(chǔ)、提高質(zhì)量控制標(biāo)準(zhǔn)、合理利用丹參藥材及含丹參中藥制劑提供參考。

Abstr：Salvia miltiorrhiza（Danshen） is a kind of Chinese materia medica（CMM）, and there has been a long history of Danshen for wide use in the treatment of numerous diseases, especially the unique therapeutic effect on cardiovascular disorders. Salvianolic acids and tanshinones are the main effective components in Danshen, which attracts the researchers’ more attention for its significant biological activity. Liquid chromatography coupled with mass spectrometry technique（LC-MS） is a rapid, sensitive, and comprehensive analytical method for the simultaneous separation and analysis, which has been widely used in the study on CMM component analysis. A large number of literatures of the application of LC-MS in the component analysis of Danshen are systematically summarized in this paper, so as to provide some indication for scientific interpretation of the effective material basis, and improve the quality control standard and comprehensive utilization of Danshen and its preparation.

文章關(guān)鍵詞：

Keyword：:Salvia miltiorrhiza Bunge salvianolic acids tanshinones liquid chromatography coupled with mass spectrometry technique quality control

課題項(xiàng)目：天津市科技創(chuàng)新專項(xiàng)資金項(xiàng)目（06FZZDSH00408）;天津市西青區(qū)科技創(chuàng)新專項(xiàng)計(jì)劃項(xiàng)目（XQCXZX2012-006）;天津市西青區(qū)科技型中小企業(yè)發(fā)展專項(xiàng)資金項(xiàng)目（XQKC2013-022）

  本文關(guān)鍵詞：液質(zhì)聯(lián)用技術(shù)在丹參成分分析中的應(yīng)用，由筆耕文化傳播整理發(fā)布。