【摘要】：目的:觀察和研究自制溫陽灸條治療早期糖尿病腎病陽虛質(zhì)的臨床療效及其對早期糖尿病腎病陽虛質(zhì)患者血肌酐、血尿素氮、尿微量白蛋白、尿白蛋白排泄率、血糖、糖化血紅蛋白等臨床指標的影響,同時,觀察自制溫陽灸條對中醫(yī)體質(zhì)調(diào)節(jié)的影響,進而探討自制溫陽灸條對早期糖尿病腎病陽虛質(zhì)治療的影響機制,為中醫(yī)外法治療早期糖尿病腎病陽虛質(zhì)提供理論依據(jù)。方法:選取70例早期糖尿病腎病陽虛質(zhì)患者,采用單盲法,隨機分為治療組35例,對照組35例。對照組采用一般性治療和常規(guī)對癥治療,再施以清艾條行溫和灸法,治療組在對照組治療基礎上換用自制溫陽灸條行溫和灸法。自制溫陽灸條藥物組成:將清艾條中艾絨與肉桂、黃芪、附子研成的細粉以2:1:1:1的比例混勻制成自制溫陽灸條,規(guī)格為直徑14mm、長度20mm。(中藥、清艾條均來源于云南中醫(yī)學院第一附屬醫(yī)院中藥房)灸雙側腎俞穴、命門穴、關元穴,雙側足三里穴,施灸時將艾條一端點燃,插入艾灸架中約距皮膚2-3cm左右,使灸架對準應灸腧穴。每穴每次15 min。每日1次,每星期6次,2星期為1個療程,共治療3個療程。治療3個療程后,觀察兩組治療前后血肌酐、血尿素氮、24小時尿蛋白定量、尿微量白蛋白、尿白蛋白排泄率、血糖、糖化血紅蛋白變化情況(安全性觀測、診斷學療效,中醫(yī)臨床癥候療效、中醫(yī)體質(zhì)調(diào)節(jié)情況)。結果:1.70例患者,10例被剔除,60例納入本研究,患者依從性大于85.71%,兩組患者在性別、年齡、病程、治療前中醫(yī)癥候評分及中醫(yī)體質(zhì)等臨床一般資料方面無顯著性差異。2.經(jīng)過3個療程治療后,治療組總有效率為83.33%;對照組總有效率為60.00%,兩組比較有顯著性差異(P㩳0.05)。3.兩組治療后,血肌酐、血尿素氮、24小時尿蛋白定量、尿微量白蛋白、尿白蛋白排泄率、血糖、糖化血紅蛋白與本組治療前比較差異均有統(tǒng)計學意義(P0.05,P0.01);治療組在降低血肌酐、24小時尿蛋白定量、尿微量白蛋白、尿白蛋白排泄率、血糖、糖化血紅蛋白方面以及改善中醫(yī)臨床證候及陽虛質(zhì)程度方面優(yōu)于對照組(P0.05,P0.01)。結論:自制溫陽灸條對早期糖尿病腎病陽虛質(zhì)有較好的臨床療效,在提高整體療效,改善患者中醫(yī)臨床癥狀,降低血肌酐、24小時尿蛋白定量、尿微量白蛋白、尿白蛋白排泄率、血糖、糖化血紅蛋白方面,治療組效果優(yōu)于對照組。
[Abstract]:Objective: to observe and study the clinical effect of self-made warming yang moxibustion strip on yang deficiency quality of early diabetic kidney disease and its effect on serum creatinine, blood urea nitrogen, urinary microalbumin, urinary albumin excretion rate and blood glucose in patients with early diabetic kidney disease yang deficiency. The effect of glycosylated hemoglobin and other clinical indexes. At the same time, the effect of self-made Wenyang moxibustion strip on physique regulation of traditional Chinese medicine was observed, and then the influence mechanism of self-made Wenyang moxibustion strip on yang deficiency and quality treatment of early diabetic kidney disease was discussed. It provides a theoretical basis for the treatment of yang deficiency in early diabetic kidney disease by external method of traditional Chinese medicine. Methods: 70 patients with yang deficiency in early diabetic kidney disease were randomly divided into treatment group (n = 35) and control group (n = 35). The control group was treated with general treatment and routine symptomatic treatment, and then Qingai strip was given the method of warming and moxibustion, while the treatment group was treated with self-made warming and moxibustion strip on the basis of the treatment of the control group. The drug composition of the self-made warming yang moxibustion strip: the fine powder prepared by mixing the fine powder of Qingai strip with cinnamon, astragalus membranaceus and aconite was made into a self-made warm yang moxibustion strip in the proportion of 2 鈮，

本文編號：2491183