【摘要】：目的：通過收集經(jīng)間期出血患者的臨床資料,對納入患者運(yùn)用補(bǔ)腎法進(jìn)行防治并對其癥狀改善情況進(jìn)行臨床觀察,同時(shí)評(píng)價(jià)補(bǔ)腎法防治經(jīng)間期出血的臨床療效,旨在為臨床治療經(jīng)間期出血提供一種防治結(jié)合的有效治療方法。方法：本組入選病例62例,對患者的一般資料進(jìn)行采集,根據(jù)患者的出血期、非出血期及生育要求等狀況給予患者相應(yīng)的補(bǔ)腎中藥湯劑口服,服藥時(shí)間超過以往的出血時(shí)間,連續(xù)治療3個(gè)月經(jīng)周期后,觀察患者的綜合療效、止血情況、主癥及次癥積分變化。將患者的一般資料及治療前后的相關(guān)數(shù)據(jù)錄入SPSS19.0并運(yùn)用該軟件進(jìn)行統(tǒng)計(jì)分析。通過中醫(yī)癥候積分變化評(píng)價(jià)補(bǔ)腎法的臨床療效,通過查閱文獻(xiàn)進(jìn)一步了解補(bǔ)腎法防治經(jīng)間期出血的作用機(jī)理。結(jié)果：1.綜合療效：本組62例患者中,痊愈21例,顯效26例,有效10例,無效5例,總有效率達(dá)91.94%。2.止血效果：本組62例患者中,痊愈37例,顯效13例,有效7例,無效5例,總有效率達(dá)91.94%。3.中醫(yī)癥候積分：治療前后的中醫(yī)癥候總積分經(jīng)秩和檢驗(yàn)Z=-6.57,P=0.000.05,治療前后的主癥積分經(jīng)秩和檢驗(yàn)Z=-7.42,P=0.000.05,差異均有統(tǒng)計(jì)學(xué)意義,結(jié)果表明治療后中醫(yī)癥候總積分及主癥積分均有明顯下降。4.相關(guān)因素與療效：年齡、病程、職業(yè)、孕產(chǎn)次、BMI均對療效無明顯影響,不同腎虛證型的患者療效亦基本相當(dāng)。然而,病情程度對療效有一定影響。結(jié)論：1.補(bǔ)腎法防治腎陽虛、腎陰虛、腎氣虛型經(jīng)間期出血可使中醫(yī)癥候評(píng)分明顯降低,綜合療效及止血療效確切,對于該病主癥及各證型次癥的改善效果顯著。近期及遠(yuǎn)期療效確切,值得臨床推廣應(yīng)用。2.對于相關(guān)因素與療效的統(tǒng)計(jì)分析表明,年齡、病程、職業(yè)、孕產(chǎn)次、BMI均對療效無明顯影響,不同腎虛證型的患者療效亦基本相當(dāng)。然而,病情程度對療效有一定影響。
[Abstract]:Objective: to collect the clinical data of patients with intermenstrual hemorrhage and to evaluate the clinical efficacy of tonifying kidney method in the prevention and treatment of intermenstrual hemorrhage by using the method of tonifying kidney and improving its symptoms, and to evaluate the clinical efficacy of tonifying kidney method in the prevention and treatment of intermenstrual hemorrhage. The aim of this study is to provide an effective method for the treatment of intermenstrual hemorrhage. Methods: 62 cases were selected and the general data of the patients were collected. According to the patient's bleeding period, non-hemorrhagic period and fertility requirement, the patients were given the corresponding tonifying kidney Chinese medicine decoction orally, the time of taking medicine was longer than the previous bleeding time, and the time of taking medicine was longer than the previous bleeding time. After 3 months of continuous treatment, the comprehensive curative effect, hemostasis, integral changes of main and secondary symptoms were observed. The general data of the patients and the related data before and after treatment were entered into SPSS19.0 and the software was used for statistical analysis. The clinical curative effect of tonifying kidney method was evaluated by the change of TCM syndrome integral, and the mechanism of tonifying kidney method to prevent and treat intermenstrual hemorrhage was further understood by consulting the literature. Results: 1. Comprehensive curative effect: 21 cases were cured, 26 cases were markedly effective, 10 cases were effective and 5 cases were ineffective. The total effective rate was 91.94%. Hemostatic effect: 37 cases were cured, 13 cases were markedly effective, 7 cases were effective and 5 cases were ineffective. The total effective rate was 91.94%. TCM symptom score: before and after treatment, the total score of TCM syndrome was tested by rank sum test (Z) 6.57, P < 0.005, and the scores of main symptoms before and after treatment were tested by rank sum test (7.42), P < 0.0005 (P < 0.05), the difference was statistically significant. The results showed that the total scores of TCM symptoms and the scores of main symptoms decreased significantly after treatment. 4. Related factors and curative effect: age, course of disease, occupation, pregnancy and childbirth, BMI had no obvious effect on the curative effect, and the curative effect of different types of kidney deficiency syndrome was basically the same as that of the patients with different types of kidney deficiency syndrome. However, the severity of the disease has a certain effect on the curative effect. Conclusion: 1. The method of tonifying the kidney to prevent and treat kidney yang deficiency, kidney yin deficiency, kidney qi deficiency type of intermenstrual hemorrhage can obviously reduce the syndrome score of traditional Chinese medicine, the comprehensive curative effect and hemostatic effect are definite, and the improvement effect is remarkable for the main disease and the secondary syndrome of each syndrome type. The short-term and long-term curative effect is definite, which is worthy of clinical application. 2. The statistical analysis of related factors and curative effect showed that age, course of disease, occupation, pregnancy and childbirth, and BMI had no significant effect on the curative effect, and the curative effect of patients with different types of kidney deficiency syndrome was basically the same as that of the patients with different types of kidney deficiency syndrome. However, the severity of the disease has a certain effect on the curative effect.
【學(xué)位授予單位】：成都中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R271.11

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