【摘要】：目的：觀察加味四物顆粒治療痰瘀互結(jié)型冠心病穩(wěn)定型心絞痛合并血脂異常的臨床療效,并探討其機制。方法：選取南京中醫(yī)藥大學(xué)附屬江陰市中醫(yī)院心血管內(nèi)科72例冠心病穩(wěn)定型心絞痛合并血脂異�；颊�,中醫(yī)辨證屬痰瘀互結(jié)型,隨機分為治療組和對照組,每組各36例。兩組患者在心絞痛Ⅰ、Ⅱ、Ⅲ各級所占人數(shù)、年齡、性別、病程等一般臨床資料方而均無明顯統(tǒng)計學(xué)差異(P0.05)。對照組予口服阿托伐他汀鈣片、阿司匹林腸溶片、心絞痛發(fā)作當時舌下含化硝酸甘油片治療。治療組在對照組的基礎(chǔ)上加用加味四物顆粒治療。治療時間為56天。對比治療前后患者心絞痛相關(guān)癥狀、中醫(yī)臨床表現(xiàn)、心中圖缺血性改變、硝酸甘油用量、血脂以及肝腎功能、血常規(guī)、尿常規(guī)、大便常規(guī)等安全性指標的變化。結(jié)果：1、心絞痛療效：在改善心絞痛癥狀方而,治療組心絞痛療效(有效率94.44%)優(yōu)于對照組(有效率77.78%),經(jīng)統(tǒng)計學(xué)分析(P0.05),有明顯統(tǒng)計學(xué)差異。2、心電圖療效：治療組有效率為80.56%,對照組有效率為55.56%,經(jīng)統(tǒng)計學(xué)分析(P0.05),治療組心電圖療效優(yōu)于對照組。3、硝酸甘油用量：經(jīng)統(tǒng)計學(xué)分析(p0.05),治療組硝酸甘油用量明顯少于對照組。4、中醫(yī)證候積分：經(jīng)統(tǒng)計學(xué)分析,治療組中醫(yī)證候積分改善優(yōu)于對照組(P0.05)。5、血脂療效：治療組血脂療效優(yōu)于對照組,治療組總有效率(91.67%),對照組的總有效率(77.78%),(P0.05),差異有統(tǒng)計學(xué)意義。在降低患者TC,TG及LDL-C方而治療組優(yōu)于對照組,在升高HDL-C方而治療組優(yōu)于對照組,差異有明顯統(tǒng)計學(xué)意義(P0.05)。結(jié)論：加味四物顆粒治療痰瘀互結(jié)型冠心病穩(wěn)定型心絞痛合并血脂異�；颊忒熜О踩煽�,其在減少心絞痛發(fā)作、改善心電圖缺血性改變、減少硝酸甘油用量、改善中醫(yī)癥狀的同時,還可改善血脂水平,為今后中醫(yī)辨證結(jié)合西醫(yī)辨病治療痰瘀互結(jié)型冠心病穩(wěn)定型心絞痛合并血脂異�；颊咛峁┮欢ǖ膮⒖�,值得臨床推廣應(yīng)用。
[Abstract]:Aim: to observe the clinical effect of Jiawei Siwu granule on stable angina pectoris complicated with dyslipidemia in phlegm-stasis type coronary heart disease (CHD), and to explore its mechanism. Methods: 72 patients with coronary heart disease stable angina pectoris complicated with dyslipidemia were selected from the Department of Cardiovascular Medicine of Jiangyin Hospital affiliated to Nanjing University of traditional Chinese Medicine. They were randomly divided into treatment group and control group with 36 cases in each group. There was no significant difference in the number, age, sex and duration of angina pectoris 鈪，

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