【摘要】：目的:探討針刺結(jié)合音樂療法對(duì)焦慮模型大鼠行為學(xué)及T淋巴細(xì)胞亞群數(shù)量的影響。方法:選用健康雌性成年SD大鼠60只,隨機(jī)分為空白對(duì)照組、模型組、針刺治療組、音樂治療組和針刺音樂治療組(簡稱音針組)。采用不可預(yù)知的慢性情緒應(yīng)激方法制作焦慮模型,造模同時(shí),針刺組、音樂組和音針組分別進(jìn)行相應(yīng)治療,觀察大鼠各組體重增長和行為學(xué)的變化、檢測(cè)全血T淋巴細(xì)胞亞群表達(dá)的百分率。結(jié)果:(1)針刺組和音針組大鼠體重較模型組顯著增長;(2)3個(gè)治療組第21天OT%值、OE%值、曠場(chǎng)試驗(yàn)水平得分及垂直得分均較模型組顯著升高;(3)與空白組相比,模型組CD8~+顯著降低,CD4~+/CD8~+顯著升高,針刺組及音針組CD8~+較模型組顯著升高,CD4~+/CD8~+較模型組顯著下降。結(jié)論:針刺結(jié)合音樂療法及針刺療法對(duì)焦慮模型大鼠的T淋巴細(xì)胞亞群起到了良性調(diào)節(jié)作用。針刺結(jié)合音樂療法有較好的抗焦慮作用。
[Abstract]:Objective: to investigate the effect of acupuncture combined with music therapy on behavior and T lymphocyte subsets in anxiety model rats. Methods: 60 healthy female adult SD rats were randomly divided into four groups: blank control group, model group, acupuncture treatment group, music treatment group and acupuncture treatment group. The anxiety model was made by means of unpredictable chronic emotional stress. At the same time, acupuncture group, music group and tone acupuncture group were treated to observe the changes of weight gain and behavior of rats in each group. The percentage of T lymphocyte subsets in whole blood was detected. Results: (1) the body weight of rats in acupuncture group and tone acupuncture group was significantly higher than that in model group, (2) at the 21st day after treatment, the scores of OT%, OEM%, open-field test level and vertical score in three treatment groups were significantly higher than those in model group. (3) compared with the blank group, CD8~ and CD4~ / CD8~ increased significantly in model group, CD8~ in acupuncture group and tone acupuncture group increased significantly compared with model group, and CD4~ / CD8~ decreased significantly compared with model group. Conclusion: acupuncture combined with music therapy and acupuncture therapy play a good role in regulating T lymphocyte subsets of anxiety model rats. Acupuncture combined with music therapy has a better anti-anxiety effect.
【作者單位】： 云南省第二人民醫(yī)院;云南中醫(yī)學(xué)院;
【基金】：云南省醫(yī)療衛(wèi)生單位內(nèi)設(shè)研究機(jī)構(gòu)(針灸研究中心)科研項(xiàng)目,編號(hào):YN2015021
【分類號(hào)】：R245;R-332

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